Effect of antidepressant treatment on plasma levels of neuroinflammation-associated molecules in patients with somatic symptom disorder with predominant pain around the orofacial region

Tomoya Miyauchi, Tatsuya Tokura, Hiroyuki Kimura, Mikiko Ito, Eri Umemura, Aiji Sato (Boku), Wataru Nagashima, Takashi Tonoike, Yasuko Yamamoto, Kuniaki Saito, Kenichi Kurita, Norio Ozaki

Research output: Contribution to journalArticle

Abstract

Objective: Burning mouth syndrome (BMS) and atypical odontalgia (AO) are examples of somatic symptom disorders with predominant pain around the orofacial region. Neuroinflammation is thought to play a role in the mechanisms, but few studies have been conducted. We aimed to better understand the role of neuroinflammation in the pathophysiology and treatment of BMS/AO. Methods: Plasma levels of 28 neuroinflammation-related molecules were determined in 44 controls and 48 BMS/AO patients both pretreatment and 12-week post-treatment with duloxetine. Results: Baseline plasma levels of interleukin (IL)-1β (p <.0001), IL-1 receptor antagonist (p <.001), IL-6 (p <.0001), macrophage inflammatory protein-1β (p <.0001), and platelet-derived growth factor-bb (.04) were significantly higher in patients than in controls. Plasma levels of granulocyte macrophage colony stimulating factor were significantly higher in patients than in controls (p <.001) and decreased with treatment (.009). Plasma levels of eotaxin, monocyte chemoattractant protein-1, and vascular endothelial growth factor decreased significantly with treatment (p <.001,.022, and.029, respectively). Conclusions: Inflammatory mechanisms may be involved in the pathophysiology and/or treatment response of somatic symptom disorders with predominant pain around the orofacial region.

Original languageEnglish
Article numbere2698
JournalHuman Psychopharmacology
Volume34
Issue number4
DOIs
Publication statusPublished - 01-07-2019

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Facial Pain
Burning Mouth Syndrome
Antidepressive Agents
Toothache
Macrophage Inflammatory Proteins
Therapeutics
Interleukin-1 Receptors
Chemokine CCL2
Platelet-Derived Growth Factor
Granulocyte-Macrophage Colony-Stimulating Factor
Interleukin-1
Vascular Endothelial Growth Factor A
Interleukin-6
Medically Unexplained Symptoms

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Pharmacology (medical)

Cite this

Miyauchi, Tomoya ; Tokura, Tatsuya ; Kimura, Hiroyuki ; Ito, Mikiko ; Umemura, Eri ; Sato (Boku), Aiji ; Nagashima, Wataru ; Tonoike, Takashi ; Yamamoto, Yasuko ; Saito, Kuniaki ; Kurita, Kenichi ; Ozaki, Norio. / Effect of antidepressant treatment on plasma levels of neuroinflammation-associated molecules in patients with somatic symptom disorder with predominant pain around the orofacial region. In: Human Psychopharmacology. 2019 ; Vol. 34, No. 4.
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title = "Effect of antidepressant treatment on plasma levels of neuroinflammation-associated molecules in patients with somatic symptom disorder with predominant pain around the orofacial region",
abstract = "Objective: Burning mouth syndrome (BMS) and atypical odontalgia (AO) are examples of somatic symptom disorders with predominant pain around the orofacial region. Neuroinflammation is thought to play a role in the mechanisms, but few studies have been conducted. We aimed to better understand the role of neuroinflammation in the pathophysiology and treatment of BMS/AO. Methods: Plasma levels of 28 neuroinflammation-related molecules were determined in 44 controls and 48 BMS/AO patients both pretreatment and 12-week post-treatment with duloxetine. Results: Baseline plasma levels of interleukin (IL)-1β (p <.0001), IL-1 receptor antagonist (p <.001), IL-6 (p <.0001), macrophage inflammatory protein-1β (p <.0001), and platelet-derived growth factor-bb (.04) were significantly higher in patients than in controls. Plasma levels of granulocyte macrophage colony stimulating factor were significantly higher in patients than in controls (p <.001) and decreased with treatment (.009). Plasma levels of eotaxin, monocyte chemoattractant protein-1, and vascular endothelial growth factor decreased significantly with treatment (p <.001,.022, and.029, respectively). Conclusions: Inflammatory mechanisms may be involved in the pathophysiology and/or treatment response of somatic symptom disorders with predominant pain around the orofacial region.",
author = "Tomoya Miyauchi and Tatsuya Tokura and Hiroyuki Kimura and Mikiko Ito and Eri Umemura and {Sato (Boku)}, Aiji and Wataru Nagashima and Takashi Tonoike and Yasuko Yamamoto and Kuniaki Saito and Kenichi Kurita and Norio Ozaki",
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Effect of antidepressant treatment on plasma levels of neuroinflammation-associated molecules in patients with somatic symptom disorder with predominant pain around the orofacial region. / Miyauchi, Tomoya; Tokura, Tatsuya; Kimura, Hiroyuki; Ito, Mikiko; Umemura, Eri; Sato (Boku), Aiji; Nagashima, Wataru; Tonoike, Takashi; Yamamoto, Yasuko; Saito, Kuniaki; Kurita, Kenichi; Ozaki, Norio.

In: Human Psychopharmacology, Vol. 34, No. 4, e2698, 01.07.2019.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Effect of antidepressant treatment on plasma levels of neuroinflammation-associated molecules in patients with somatic symptom disorder with predominant pain around the orofacial region

AU - Miyauchi, Tomoya

AU - Tokura, Tatsuya

AU - Kimura, Hiroyuki

AU - Ito, Mikiko

AU - Umemura, Eri

AU - Sato (Boku), Aiji

AU - Nagashima, Wataru

AU - Tonoike, Takashi

AU - Yamamoto, Yasuko

AU - Saito, Kuniaki

AU - Kurita, Kenichi

AU - Ozaki, Norio

PY - 2019/7/1

Y1 - 2019/7/1

N2 - Objective: Burning mouth syndrome (BMS) and atypical odontalgia (AO) are examples of somatic symptom disorders with predominant pain around the orofacial region. Neuroinflammation is thought to play a role in the mechanisms, but few studies have been conducted. We aimed to better understand the role of neuroinflammation in the pathophysiology and treatment of BMS/AO. Methods: Plasma levels of 28 neuroinflammation-related molecules were determined in 44 controls and 48 BMS/AO patients both pretreatment and 12-week post-treatment with duloxetine. Results: Baseline plasma levels of interleukin (IL)-1β (p <.0001), IL-1 receptor antagonist (p <.001), IL-6 (p <.0001), macrophage inflammatory protein-1β (p <.0001), and platelet-derived growth factor-bb (.04) were significantly higher in patients than in controls. Plasma levels of granulocyte macrophage colony stimulating factor were significantly higher in patients than in controls (p <.001) and decreased with treatment (.009). Plasma levels of eotaxin, monocyte chemoattractant protein-1, and vascular endothelial growth factor decreased significantly with treatment (p <.001,.022, and.029, respectively). Conclusions: Inflammatory mechanisms may be involved in the pathophysiology and/or treatment response of somatic symptom disorders with predominant pain around the orofacial region.

AB - Objective: Burning mouth syndrome (BMS) and atypical odontalgia (AO) are examples of somatic symptom disorders with predominant pain around the orofacial region. Neuroinflammation is thought to play a role in the mechanisms, but few studies have been conducted. We aimed to better understand the role of neuroinflammation in the pathophysiology and treatment of BMS/AO. Methods: Plasma levels of 28 neuroinflammation-related molecules were determined in 44 controls and 48 BMS/AO patients both pretreatment and 12-week post-treatment with duloxetine. Results: Baseline plasma levels of interleukin (IL)-1β (p <.0001), IL-1 receptor antagonist (p <.001), IL-6 (p <.0001), macrophage inflammatory protein-1β (p <.0001), and platelet-derived growth factor-bb (.04) were significantly higher in patients than in controls. Plasma levels of granulocyte macrophage colony stimulating factor were significantly higher in patients than in controls (p <.001) and decreased with treatment (.009). Plasma levels of eotaxin, monocyte chemoattractant protein-1, and vascular endothelial growth factor decreased significantly with treatment (p <.001,.022, and.029, respectively). Conclusions: Inflammatory mechanisms may be involved in the pathophysiology and/or treatment response of somatic symptom disorders with predominant pain around the orofacial region.

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JO - Human Psychopharmacology

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SN - 0885-6222

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