Effect of aripiprazole, risperidone, and olanzapine on the acoustic startle response in Japanese chronic schizophrenia

Taro Kishi, Masatsugu Moriwaki, Tsuyoshi Kitajima, Kunihiro Kawashima, Tomo Okochi, Yasuhisa Fukuo, Osamu Furukawa, Hiroshi Naitoh, Kiyoshi Fujita, Nakao Iwata

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background Studies have also shown that differences in the kind of the antipsychotics influenced disruption of the sensorimotor gating system, including prepulse inhibition (PPI), acoustic startle reflex (ASR), and habituation (HAB). We investigated the influence on startle response in chronic schizophrenia in 20 patients with schizophrenia taking risperidone, 21 patients with schizophrenia taking olanzapine, and 20 patients with schizophrenia taking aripiprazole. Method The patients who participated in this study were on maintenance therapy with only one antipsychotic drug for 4 months. We performed the test for the association between all PPI measures (ASR, HAB, and PPI at prepulse sound pressure intensities of 82, 86, and 90 dB) and each the risperidene, olanzapine, and aripiprazole groups, with analysis of covariance (ANCOVA; using age, duration of illness, and daily dose of the antipsychotic as covariates). Also, when significant difference was detected in ANCOVA, the differences of PPI measures between every pairs of two drug groups were tested as a post hoc analysis with the use of t test and Bonferroni's correction of multiple tests. Result We found that PPI90 showed significant differences with ANCOVA among patients with schizophrenia taking each of the antipsychotics. When we performed a post hoc analysis for PPI90, the value was higher in the aripiprazole group than in the olanzapine group and higher in the risperidone group than in the olanzapine group. Conclusion Aripiprazole and risperidone may improve PPI90. ASR, HAB, PPI82, and PPI86 were no different among the Japanese schizophrenic patient groups with different antipsychotics.

Original languageEnglish
Pages (from-to)185-190
Number of pages6
JournalPsychopharmacology
Volume209
Issue number2
DOIs
Publication statusPublished - 01-04-2010

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olanzapine
Startle Reflex
Risperidone
Acoustics
Schizophrenia
Antipsychotic Agents
Sensory Gating
Aripiprazole
Pressure

All Science Journal Classification (ASJC) codes

  • Pharmacology

Cite this

Kishi, Taro ; Moriwaki, Masatsugu ; Kitajima, Tsuyoshi ; Kawashima, Kunihiro ; Okochi, Tomo ; Fukuo, Yasuhisa ; Furukawa, Osamu ; Naitoh, Hiroshi ; Fujita, Kiyoshi ; Iwata, Nakao. / Effect of aripiprazole, risperidone, and olanzapine on the acoustic startle response in Japanese chronic schizophrenia. In: Psychopharmacology. 2010 ; Vol. 209, No. 2. pp. 185-190.
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Kishi, T, Moriwaki, M, Kitajima, T, Kawashima, K, Okochi, T, Fukuo, Y, Furukawa, O, Naitoh, H, Fujita, K & Iwata, N 2010, 'Effect of aripiprazole, risperidone, and olanzapine on the acoustic startle response in Japanese chronic schizophrenia', Psychopharmacology, vol. 209, no. 2, pp. 185-190. https://doi.org/10.1007/s00213-010-1787-x

Effect of aripiprazole, risperidone, and olanzapine on the acoustic startle response in Japanese chronic schizophrenia. / Kishi, Taro; Moriwaki, Masatsugu; Kitajima, Tsuyoshi; Kawashima, Kunihiro; Okochi, Tomo; Fukuo, Yasuhisa; Furukawa, Osamu; Naitoh, Hiroshi; Fujita, Kiyoshi; Iwata, Nakao.

In: Psychopharmacology, Vol. 209, No. 2, 01.04.2010, p. 185-190.

Research output: Contribution to journalArticle

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T1 - Effect of aripiprazole, risperidone, and olanzapine on the acoustic startle response in Japanese chronic schizophrenia

AU - Kishi, Taro

AU - Moriwaki, Masatsugu

AU - Kitajima, Tsuyoshi

AU - Kawashima, Kunihiro

AU - Okochi, Tomo

AU - Fukuo, Yasuhisa

AU - Furukawa, Osamu

AU - Naitoh, Hiroshi

AU - Fujita, Kiyoshi

AU - Iwata, Nakao

PY - 2010/4/1

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N2 - Background Studies have also shown that differences in the kind of the antipsychotics influenced disruption of the sensorimotor gating system, including prepulse inhibition (PPI), acoustic startle reflex (ASR), and habituation (HAB). We investigated the influence on startle response in chronic schizophrenia in 20 patients with schizophrenia taking risperidone, 21 patients with schizophrenia taking olanzapine, and 20 patients with schizophrenia taking aripiprazole. Method The patients who participated in this study were on maintenance therapy with only one antipsychotic drug for 4 months. We performed the test for the association between all PPI measures (ASR, HAB, and PPI at prepulse sound pressure intensities of 82, 86, and 90 dB) and each the risperidene, olanzapine, and aripiprazole groups, with analysis of covariance (ANCOVA; using age, duration of illness, and daily dose of the antipsychotic as covariates). Also, when significant difference was detected in ANCOVA, the differences of PPI measures between every pairs of two drug groups were tested as a post hoc analysis with the use of t test and Bonferroni's correction of multiple tests. Result We found that PPI90 showed significant differences with ANCOVA among patients with schizophrenia taking each of the antipsychotics. When we performed a post hoc analysis for PPI90, the value was higher in the aripiprazole group than in the olanzapine group and higher in the risperidone group than in the olanzapine group. Conclusion Aripiprazole and risperidone may improve PPI90. ASR, HAB, PPI82, and PPI86 were no different among the Japanese schizophrenic patient groups with different antipsychotics.

AB - Background Studies have also shown that differences in the kind of the antipsychotics influenced disruption of the sensorimotor gating system, including prepulse inhibition (PPI), acoustic startle reflex (ASR), and habituation (HAB). We investigated the influence on startle response in chronic schizophrenia in 20 patients with schizophrenia taking risperidone, 21 patients with schizophrenia taking olanzapine, and 20 patients with schizophrenia taking aripiprazole. Method The patients who participated in this study were on maintenance therapy with only one antipsychotic drug for 4 months. We performed the test for the association between all PPI measures (ASR, HAB, and PPI at prepulse sound pressure intensities of 82, 86, and 90 dB) and each the risperidene, olanzapine, and aripiprazole groups, with analysis of covariance (ANCOVA; using age, duration of illness, and daily dose of the antipsychotic as covariates). Also, when significant difference was detected in ANCOVA, the differences of PPI measures between every pairs of two drug groups were tested as a post hoc analysis with the use of t test and Bonferroni's correction of multiple tests. Result We found that PPI90 showed significant differences with ANCOVA among patients with schizophrenia taking each of the antipsychotics. When we performed a post hoc analysis for PPI90, the value was higher in the aripiprazole group than in the olanzapine group and higher in the risperidone group than in the olanzapine group. Conclusion Aripiprazole and risperidone may improve PPI90. ASR, HAB, PPI82, and PPI86 were no different among the Japanese schizophrenic patient groups with different antipsychotics.

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