Effect of continuous intravenous oxycodone infusion in opioid-naïve cancer patients with dyspnea

Yoshihiro Yamamoto, Hiroaki Watanabe, Aina Sakurai, Yuko Deguchi, Shigeki Hirano, Yoshimi Okumura, Akiko Kumon, Norio Watanabe, Takashi Osada, Keiko Yamamura, Takuya Odagiri

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)


Aim: Dyspnea is among symptoms that decrease quality of life for terminal cancer patients. There are few reports of the positive effects of oxycodone for the treatment of dyspnea, and no studies have focused on opioid-naïve patients. This study aimed to determine the efficacy and safety of continuous intravenous oxycodone infusion for opioid-naïve cancer patients with dyspnea. Methods: Eligible patients were opioid-naïve cancer inpatients who received continuous oxycodone infusion as a treatment for dyspnea under the care of the palliative care team at Komaki City Hospital between November 2013 and December 2016. We retrospectively investigated the improvement of dyspnea following continuous oxycodone infusion from the medical records. Results: This study included 19 patients, and the response rate to oxycodone infusion for dyspnea was 68.4%. Most participants were terminal cancer patients with performance status 3 or 4. Median survival of participants following continuous oxycodone infusion was 6 (range 1–377) days. No serious adverse events such as respiratory depression or somnolence were noted. Conclusion: Continuous oxycodone infusion could be a reasonable treatment option in the management of dyspnea in opioid-naïve cancer patients.

Original languageEnglish
Pages (from-to)748-752
Number of pages5
JournalJapanese journal of clinical oncology
Issue number8
Publication statusPublished - 01-08-2018
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research


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