Abstract
Morphine is used to alleviate chronic cancer pain. However, constipation is a major adverse effect that often detracts from the patient's quality of life. In this study, we investigated the effectiveness of dietary fiber on morphine-induced constipation. Rats were fed on a normal diet or one containing either 10% or 20% apple fiber for two weeks before morphine was administered. In the control diet group, the fecal number and dry weight were decreased by treating with morphine in a dose-dependent manner. Moreover, the motility of the small and large intestines was reduced. The fecal number and weight were increased and the colon motility was promoted by dietary fiber, regardless of whether morphine was being administered. The dietary fiber increased the concentration of short-chain fatty acids (SCFAs) in the cecum. These results suggest that dietary fiber has a preventative effect on morphine-induced constipation by increasing SCFAs in the cecum, and thereby promoting colon motility in rats.
| Original language | English |
|---|---|
| Pages (from-to) | 1233-1240 |
| Number of pages | 8 |
| Journal | Bioscience, Biotechnology and Biochemistry |
| Volume | 66 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 01-01-2002 |
| Externally published | Yes |
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All Science Journal Classification (ASJC) codes
- Analytical Chemistry
- Biotechnology
- Biochemistry
- Applied Microbiology and Biotechnology
- Molecular Biology
- Organic Chemistry
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Effect of dietary fiber on morphine-induced constipation in rats. / Niwa, Takashi; Nakao, Makoto; Hoshi, Seiko; Yamada, Kiyofumi; Inagaki, Kazuhiro; Nishida, Mikio; Nabeshima, Toshitaka.
In: Bioscience, Biotechnology and Biochemistry, Vol. 66, No. 6, 01.01.2002, p. 1233-1240.Research output: Contribution to journal › Article
TY - JOUR
T1 - Effect of dietary fiber on morphine-induced constipation in rats
AU - Niwa, Takashi
AU - Nakao, Makoto
AU - Hoshi, Seiko
AU - Yamada, Kiyofumi
AU - Inagaki, Kazuhiro
AU - Nishida, Mikio
AU - Nabeshima, Toshitaka
PY - 2002/1/1
Y1 - 2002/1/1
N2 - Morphine is used to alleviate chronic cancer pain. However, constipation is a major adverse effect that often detracts from the patient's quality of life. In this study, we investigated the effectiveness of dietary fiber on morphine-induced constipation. Rats were fed on a normal diet or one containing either 10% or 20% apple fiber for two weeks before morphine was administered. In the control diet group, the fecal number and dry weight were decreased by treating with morphine in a dose-dependent manner. Moreover, the motility of the small and large intestines was reduced. The fecal number and weight were increased and the colon motility was promoted by dietary fiber, regardless of whether morphine was being administered. The dietary fiber increased the concentration of short-chain fatty acids (SCFAs) in the cecum. These results suggest that dietary fiber has a preventative effect on morphine-induced constipation by increasing SCFAs in the cecum, and thereby promoting colon motility in rats.
AB - Morphine is used to alleviate chronic cancer pain. However, constipation is a major adverse effect that often detracts from the patient's quality of life. In this study, we investigated the effectiveness of dietary fiber on morphine-induced constipation. Rats were fed on a normal diet or one containing either 10% or 20% apple fiber for two weeks before morphine was administered. In the control diet group, the fecal number and dry weight were decreased by treating with morphine in a dose-dependent manner. Moreover, the motility of the small and large intestines was reduced. The fecal number and weight were increased and the colon motility was promoted by dietary fiber, regardless of whether morphine was being administered. The dietary fiber increased the concentration of short-chain fatty acids (SCFAs) in the cecum. These results suggest that dietary fiber has a preventative effect on morphine-induced constipation by increasing SCFAs in the cecum, and thereby promoting colon motility in rats.
UR - http://www.scopus.com/inward/record.url?scp=0036618145&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036618145&partnerID=8YFLogxK
U2 - 10.1271/bbb.66.1233
DO - 10.1271/bbb.66.1233
M3 - Article
C2 - 12162543
AN - SCOPUS:0036618145
VL - 66
SP - 1233
EP - 1240
JO - Bioscience, Biotechnology and Biochemistry
JF - Bioscience, Biotechnology and Biochemistry
SN - 0916-8451
IS - 6
ER -