Effect of dizocilpine (MK-801) on the catalepsy induced by Δ9-tetrahydrocannabinol in mice

H. Kinoshita, T. Hasegawa, Y. Katsumata, T. Kameyama, I. Yamamoto, T. Nabeshima

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Mice treated with Δ9-tetrahydrocannabinol (THC; 5 and 10mg/kg i.v.) showed the catalepsy in high bar test, and median descent latencies of catalepsy were about 150 sec. Dizocilpine (MK-801, 0.05 and 0.1mg/kg), non-competitive N-methyl-D-aspartate (NMDA) antagonist, significantly attenuated THC-induced catalepsy. Furthermore, the anticataleptic effect of MK-801 on THC-induced catalepsy was blocked by acetylcholine agonist oxotremorine (0.005 mg/kg) and dopamine antagonist haloperidol (0.01mg/kg), but not by NMDA. Oxotremorine, haloperidol, and NMDA themselves did not affect THC-induced catalepsy at the doses used. These results suggest that the anticataleptic effect of MK-801 on THC-induced catalepsy may be developed through dopaminergic and acetylcholinergic neuronal systems.

Original languageEnglish
Pages (from-to)137-143
Number of pages7
JournalJournal of Neural Transmission
Volume95
Issue number2
DOIs
Publication statusPublished - 01-06-1994
Externally publishedYes

Fingerprint

Catalepsy
Dronabinol
Dizocilpine Maleate
N-Methylaspartate
Oxotremorine
Haloperidol
Cholinergic Agonists
Dopamine Antagonists

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Kinoshita, H. ; Hasegawa, T. ; Katsumata, Y. ; Kameyama, T. ; Yamamoto, I. ; Nabeshima, T. / Effect of dizocilpine (MK-801) on the catalepsy induced by Δ9-tetrahydrocannabinol in mice. In: Journal of Neural Transmission. 1994 ; Vol. 95, No. 2. pp. 137-143.
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abstract = "Mice treated with Δ9-tetrahydrocannabinol (THC; 5 and 10mg/kg i.v.) showed the catalepsy in high bar test, and median descent latencies of catalepsy were about 150 sec. Dizocilpine (MK-801, 0.05 and 0.1mg/kg), non-competitive N-methyl-D-aspartate (NMDA) antagonist, significantly attenuated THC-induced catalepsy. Furthermore, the anticataleptic effect of MK-801 on THC-induced catalepsy was blocked by acetylcholine agonist oxotremorine (0.005 mg/kg) and dopamine antagonist haloperidol (0.01mg/kg), but not by NMDA. Oxotremorine, haloperidol, and NMDA themselves did not affect THC-induced catalepsy at the doses used. These results suggest that the anticataleptic effect of MK-801 on THC-induced catalepsy may be developed through dopaminergic and acetylcholinergic neuronal systems.",
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Effect of dizocilpine (MK-801) on the catalepsy induced by Δ9-tetrahydrocannabinol in mice. / Kinoshita, H.; Hasegawa, T.; Katsumata, Y.; Kameyama, T.; Yamamoto, I.; Nabeshima, T.

In: Journal of Neural Transmission, Vol. 95, No. 2, 01.06.1994, p. 137-143.

Research output: Contribution to journalArticle

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T1 - Effect of dizocilpine (MK-801) on the catalepsy induced by Δ9-tetrahydrocannabinol in mice

AU - Kinoshita, H.

AU - Hasegawa, T.

AU - Katsumata, Y.

AU - Kameyama, T.

AU - Yamamoto, I.

AU - Nabeshima, T.

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AB - Mice treated with Δ9-tetrahydrocannabinol (THC; 5 and 10mg/kg i.v.) showed the catalepsy in high bar test, and median descent latencies of catalepsy were about 150 sec. Dizocilpine (MK-801, 0.05 and 0.1mg/kg), non-competitive N-methyl-D-aspartate (NMDA) antagonist, significantly attenuated THC-induced catalepsy. Furthermore, the anticataleptic effect of MK-801 on THC-induced catalepsy was blocked by acetylcholine agonist oxotremorine (0.005 mg/kg) and dopamine antagonist haloperidol (0.01mg/kg), but not by NMDA. Oxotremorine, haloperidol, and NMDA themselves did not affect THC-induced catalepsy at the doses used. These results suggest that the anticataleptic effect of MK-801 on THC-induced catalepsy may be developed through dopaminergic and acetylcholinergic neuronal systems.

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