TY - JOUR
T1 - Effect of donor type on volume of blood transfusions required after allogeneic hematopoietic cell transplantation
AU - Kurosawa, Saiko
AU - Yamaguchi, Takuhiro
AU - Nakabayashi, Saori
AU - Kasane, Moemi
AU - Tsubokura, Misato
AU - Iwashita, Nao
AU - Minakawa, Yuki
AU - Ohtake, Ryuzaburo
AU - Kawamura, Kimihiko
AU - Nishioka, Yukiko
AU - Takeda, Wataru
AU - Hirakawa, Tuneaki
AU - Aoki, Jun
AU - Ito, Ayumu
AU - Tanaka, Takashi
AU - Inamoto, Yoshihiro
AU - Kim, Sung Won
AU - Kojima, Minoru
AU - Takanashi, Minoko
AU - Fukuda, Takahiro
N1 - Publisher Copyright:
© 2021, Japanese Society of Hematology.
PY - 2021/4
Y1 - 2021/4
N2 - We reviewed blood product use in 729 consecutive allogeneic hematopoietic cell transplantation (allo-HCT) recipients at our center to assess the volume of red blood cells (RBCs) and platelets required after allo-HCT. The median number of bags required by day 30 was 4 for RBCs (range 0–22) and 9.5 for platelets (0–53). Multivariate analysis showed that related peripheral blood stem cell transplantation (PBSCT) required a significantly lower RBC transfusion volume by day 30 compared to unrelated bone marrow transplantation (UBMT). PBSCT from haplo-identical related donors and cord blood transplantation (CBT) required a significantly greater RBC transfusion volume. For platelet transfusion, related and unrelated PBSCT required a significantly lower volume than UBMT, and CBT a greater volume. Other factors independently associated with greater RBC transfusion volume were male sex, disease status other than complete remission, and major ABO mismatch. For platelet transfusion, these were male sex, disease status, and HCT-specific comorbidity index of 1. Although the burden of blood transfusions may not be the most important factor when choosing a donor type, our findings may provide a foundation for nationwide strategies to prepare blood products and inform aspects of national healthcare expenditures.
AB - We reviewed blood product use in 729 consecutive allogeneic hematopoietic cell transplantation (allo-HCT) recipients at our center to assess the volume of red blood cells (RBCs) and platelets required after allo-HCT. The median number of bags required by day 30 was 4 for RBCs (range 0–22) and 9.5 for platelets (0–53). Multivariate analysis showed that related peripheral blood stem cell transplantation (PBSCT) required a significantly lower RBC transfusion volume by day 30 compared to unrelated bone marrow transplantation (UBMT). PBSCT from haplo-identical related donors and cord blood transplantation (CBT) required a significantly greater RBC transfusion volume. For platelet transfusion, related and unrelated PBSCT required a significantly lower volume than UBMT, and CBT a greater volume. Other factors independently associated with greater RBC transfusion volume were male sex, disease status other than complete remission, and major ABO mismatch. For platelet transfusion, these were male sex, disease status, and HCT-specific comorbidity index of 1. Although the burden of blood transfusions may not be the most important factor when choosing a donor type, our findings may provide a foundation for nationwide strategies to prepare blood products and inform aspects of national healthcare expenditures.
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U2 - 10.1007/s12185-020-03041-2
DO - 10.1007/s12185-020-03041-2
M3 - Article
C2 - 33392973
AN - SCOPUS:85098543278
SN - 0925-5710
VL - 113
SP - 518
EP - 529
JO - International Journal of Hematology
JF - International Journal of Hematology
IS - 4
ER -