TY - JOUR
T1 - Effect of doxycycline on the generation of reactive oxygen species
T2 - A possible mechanism of action of acne therapy with doxycycline
AU - Akamatsu, H.
AU - Asada, M.
AU - Komura, J.
AU - Asada, Y.
AU - Niwa, Y.
PY - 1992
Y1 - 1992
N2 - On the basis of a recent report that minocycline is effective in the treatment of acne inflammation by acting directly as an antioxidant on infiltrating neutrophils, we investigated whether doxycycline might also be capable of reducing the generation of reactive oxygen species, using human neutrophils and a cell-free, xanthine-xanthine oxidase system. The species investigated are superoxide radical anion (O2-), hydrogen peroxide (H2O2) and hydroxyl radical (OH·). Doxycycline significantly reduced the levels of O2-, H2O2 and OH· generated by both systems. Our results seem to suggest that the clinical effectiveness of doxycycline in the treatment of acne inflammation is due partly to its antioxidant effect on neutrophils.
AB - On the basis of a recent report that minocycline is effective in the treatment of acne inflammation by acting directly as an antioxidant on infiltrating neutrophils, we investigated whether doxycycline might also be capable of reducing the generation of reactive oxygen species, using human neutrophils and a cell-free, xanthine-xanthine oxidase system. The species investigated are superoxide radical anion (O2-), hydrogen peroxide (H2O2) and hydroxyl radical (OH·). Doxycycline significantly reduced the levels of O2-, H2O2 and OH· generated by both systems. Our results seem to suggest that the clinical effectiveness of doxycycline in the treatment of acne inflammation is due partly to its antioxidant effect on neutrophils.
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M3 - Article
C2 - 1357852
AN - SCOPUS:0026533687
SN - 0001-5555
VL - 72
SP - 178
EP - 179
JO - Acta Dermato-Venereologica
JF - Acta Dermato-Venereologica
IS - 3
ER -