Effect of duodenal mucosal blood flow on duodenal alkaline secretion in rats

Y. Tsukamoto, H. Goto, S. Hase, T. Arisawa, A. Ohara, T. Suzuki, H. Hoshino, H. Endo, E. Hamajima, N. Ohmiya

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


To investigate the role of duodenal mucosal blood flow (DMBF) in the regulation of duodenal alkaline secretion (DAS), both parameters were measured before and after the administration of various drugs in rats. The DMBF was determined using an electrolytically generated hydrogen gas clearance technique, and the DAS was measured by the perfusion method. The administration of dulcerozine, a potent duodenal ulcerogenic agent, at a dose of 250 mg/kg and serotonin at a dose of 20 mg/kg, which produces duodenal ulcerations with an acid load, decreased both DMBF and DAS. On the other hand, the administration of secretin at a dose of 10 U/kg increased both parameters. There were parallel changes in DMBF and DAS. It is concluded, therefore, that DAS may be regulated by DMBF and that both parameters may be involved in the defense mechanism of duodenal mucosa.

Original languageEnglish
Pages (from-to)198-202
Number of pages5
Issue number4
Publication statusPublished - 1992
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Gastroenterology


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