Effect of early eradication on Helicobacter pylorirelated gastric carcinogenesis in Mongolian gerbils

Koji Nozaki, Nobuyuki Shimizu, Yuzuru Ikehara, Manami Inoue, Tetsuya Tsukamoto, Ken Ichi Inada, Harunari Tanaka, Toshiko Kumagai, Michio Kaminishi, Masae Tatematsu

Research output: Contribution to journalArticlepeer-review

120 Citations (Scopus)


Helicobacter pylori (Hp) infection and gastric carcinogenesis are known to have a close relationship, but the effect of eradication of Hp on Hp-related gastric carcinogenesis has not been fully studied experimentally. To evaluate the effect of eradication in gastric carcinogenesis, an experimental model with eradication in the early, middle or late period was studied using Hp-infected and N-methyl-N-nitrosourea (MNU)-treated Mongolian gerbils. The animals were divided into seven groups: group A (MNU+Hp+ eradication at 15 w), group B (MNU+Hp+eradication at 35 w), group C (MNU+Hp+eradication at 55 w), group D (MNU+Hp), group E (MNU), group F (Hp) and group G (control). The tumor incidences at week 75 in the early (group A), middle (group B) and late (group C) eradicated groups were 6.7%, 27.3% and 38.2%, respectively. The incidence of 56.3% in the non-eradicated group was the highest (group D). Incidences in group E, group F and group G were 6.3%, 0.0% and 0.0%, respectively. The tumor incidences were related to the period of inflammatory status induced by Hp infection. Hp infection strongly enhanced gastric carcinogenesis initiated with a chemical carcinogen, and following eradication at an early period this enhancing effect was effectively reduced. Eradication at an early stage of inflammation might be effective in preventing Hp-related gastric carcinogenesis.

Original languageEnglish
Pages (from-to)235-239
Number of pages5
JournalCancer science
Issue number3
Publication statusPublished - 01-03-2003
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research


Dive into the research topics of 'Effect of early eradication on Helicobacter pylorirelated gastric carcinogenesis in Mongolian gerbils'. Together they form a unique fingerprint.

Cite this