TY - JOUR
T1 - Effect of erythropoietin-stimulating agent on uremic inflammation
AU - Tanaka, Yuri
AU - Joki, Nobuhiko
AU - Hase, Hiroki
AU - Iwasaki, Masaki
AU - Ikeda, Masato
AU - Ando, Ryoichi
AU - Shinoda, Toshio
AU - Inaguma, Daijo
AU - Sakaguchi, Toshifumi
AU - Komatsu, Yasuhiro
AU - Koiwa, Fumihiko
AU - Yamaka, Toshihiko
AU - Shigematsu, Takashi
PY - 2012
Y1 - 2012
N2 - Background: The goal of the present study was to explore the effect of medications that are commonly prescribed for CKD patients on uremic state. Methods: This was a cross-sectional study. From January 2006 to October 2009, 1,623 patients with end-stage kidney disease (ESKD) commenced hemodialysis (HD) at the 9 participating hospitals. The criteria for exclusion from the database were 1) serum C-reactive protein (CRP) >3 mg/dL, 2) WBC count >9,000/mm3 or <4,000/mm3, and 3) patients with cancer, immune complex disease, or vasculitis. A total of 900 patients were entered into the final database. We explored the association of serum CRP just before the first HD session with clinical characteristics, laboratory data, and medications for CKD in the predialysis period. Results: On univariate analysis, age, CTR, eGFR, and WBC were significantly correlated with CRP. Systolic and diastolic blood pressure, serum albumin, LDL-C, HDL-C, Hb, Cr, and Ca were inversely associated with CRP. Use of erythropoietin-stimulating agents (ESA) using (r = ?0.111, p = 0.0015), renin-angiotensin-aldosterone system inhibitors (r = ?0.083, p = 0.0154), and calcium channel blockers (r = ?0.1, p = 0.0039) was also negatively correlated with CRP. However, only use of ESA showed a significant negative correlation with CRP that was independent of other clinical factors and CKD medications on multiple regression analysis. Conclusion: ESA may strongly reduce uremic inflammation in addition to improving anemia. To confirm this potential effect, a large-scale longitudinal study would be required.
AB - Background: The goal of the present study was to explore the effect of medications that are commonly prescribed for CKD patients on uremic state. Methods: This was a cross-sectional study. From January 2006 to October 2009, 1,623 patients with end-stage kidney disease (ESKD) commenced hemodialysis (HD) at the 9 participating hospitals. The criteria for exclusion from the database were 1) serum C-reactive protein (CRP) >3 mg/dL, 2) WBC count >9,000/mm3 or <4,000/mm3, and 3) patients with cancer, immune complex disease, or vasculitis. A total of 900 patients were entered into the final database. We explored the association of serum CRP just before the first HD session with clinical characteristics, laboratory data, and medications for CKD in the predialysis period. Results: On univariate analysis, age, CTR, eGFR, and WBC were significantly correlated with CRP. Systolic and diastolic blood pressure, serum albumin, LDL-C, HDL-C, Hb, Cr, and Ca were inversely associated with CRP. Use of erythropoietin-stimulating agents (ESA) using (r = ?0.111, p = 0.0015), renin-angiotensin-aldosterone system inhibitors (r = ?0.083, p = 0.0154), and calcium channel blockers (r = ?0.1, p = 0.0039) was also negatively correlated with CRP. However, only use of ESA showed a significant negative correlation with CRP that was independent of other clinical factors and CKD medications on multiple regression analysis. Conclusion: ESA may strongly reduce uremic inflammation in addition to improving anemia. To confirm this potential effect, a large-scale longitudinal study would be required.
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U2 - 10.1186/1476-9255-9-17
DO - 10.1186/1476-9255-9-17
M3 - Article
AN - SCOPUS:84860805137
SN - 1476-9255
VL - 9
JO - Journal of Inflammation (United Kingdom)
JF - Journal of Inflammation (United Kingdom)
M1 - 17
ER -
