TY - JOUR
T1 - Effect of evening light exposure on sleep in bipolar disorder
T2 - A longitudinal analysis for repeated measures in the APPLE cohort
AU - Esaki, Yuichi
AU - Obayashi, Kenji
AU - Saeki, Keigo
AU - Fujita, Kiyoshi
AU - Iwata, Nakao
AU - Kitajima, Tsuyoshi
N1 - Funding Information:
The author(s) declared the following potential conflicts of interest with respect to the research, authorship and/or publication of this article: Y.E. has received manuscript fees from Dainippon Sumitomo. K.O. and K.S. have received a research grant from YKK AP Inc.; Ushio Inc.; Tokyo Electric Power Company; EnviroLife Research Institute Co., Ltd.; Sekisui Chemical Co., Ltd; LIXIL Corp.; and KYOCERA Corp. K.F. has received speaker’s honoraria from Dainippon Sumitomo, Eli Lilly, GlaxoSmithKline, Janssen, Yoshitomi, Otsuka, Meiji, Shionogi, Novartis and Kracie. N.I. has received speaker’s honoraria from Astellas, Dainippon Sumitomo, Eli Lilly, GlaxoSmithKline, Janssen, Yoshitomi, Otsuka, Meiji, Shionogi, Novartis and Pfizer and has had research grants from GlaxoSmithKline, Meiji, Otsuka, Mitsubishi Tanabe, Dainippon Sumitomo, Daiichisankyo and Eisai. T.K. has received speaker’s honoraria from Eisai, Mitsubishi Tanabe, Otsuka, Takeda, Eli Lilly, MSD, Meiji, Yoshitomi, Fukuda, Dainippon Sumitomo, Shionogi and Novo Nordisk and has received a research grant from Eisai, MSD and Takeda.
Funding Information:
The author(s) disclosed receipt of the following financial support for the research, authorship and/or publication of this article: This work was supported by Scientific Research from JSPS KAKENHI (grant number 18K15529), Japan Foundation for Neuroscience and Mental Health and The Neuroscience Research Center.
Publisher Copyright:
© The Royal Australian and New Zealand College of Psychiatrists 2020.
Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2021/3
Y1 - 2021/3
N2 - Objective: Sleep disturbance, a core feature of bipolar disorder, is associated with residual mood symptoms, mood episode recurrence and suicide ideation. We investigated the effect of evening light exposure on sleep in patients with bipolar disorder. Methods: In this longitudinal analysis, we measured the sleep parameters of 207 outpatients with bipolar disorder using actigraphy at their homes for seven consecutive nights. We measured the white-light illuminance and the irradiance of each wavelength during the 4 hours before each participant’s bedtime. We used mixed-effect linear regression analysis for repeated measures to evaluate the effect of evening light exposure on subsequent sleep parameters. Results: The median white-light illuminance was 25.8 lux (interquartile range, 12.9–50.1 lux). In a multivariable model adjusted for potential confounders, we found higher white-light illuminance to be significantly associated with lower sleep efficiency (per log lux: 95% confidence interval = [−1.328, −0.133]; p = 0.017), prolonged sleep-onset latency (95% confidence interval = [0.006, 0.172]; p = 0.035) and longer wake after sleep onset (95% confidence interval = [1.104, 4.459]; p = 0.001). This effect size was larger in the younger age group (aged < 44 years) stratified by median age. Higher irradiance of the blue wavelength range was significantly associated with longer wake after sleep onset, a result similar to those for the green and red wavelength ranges. Conclusion: We observed significant associations between evening light exposure and subsequent sleep in patients with bipolar disorder. The effects of various light wavelengths on sleep in bipolar disorder require further investigation.
AB - Objective: Sleep disturbance, a core feature of bipolar disorder, is associated with residual mood symptoms, mood episode recurrence and suicide ideation. We investigated the effect of evening light exposure on sleep in patients with bipolar disorder. Methods: In this longitudinal analysis, we measured the sleep parameters of 207 outpatients with bipolar disorder using actigraphy at their homes for seven consecutive nights. We measured the white-light illuminance and the irradiance of each wavelength during the 4 hours before each participant’s bedtime. We used mixed-effect linear regression analysis for repeated measures to evaluate the effect of evening light exposure on subsequent sleep parameters. Results: The median white-light illuminance was 25.8 lux (interquartile range, 12.9–50.1 lux). In a multivariable model adjusted for potential confounders, we found higher white-light illuminance to be significantly associated with lower sleep efficiency (per log lux: 95% confidence interval = [−1.328, −0.133]; p = 0.017), prolonged sleep-onset latency (95% confidence interval = [0.006, 0.172]; p = 0.035) and longer wake after sleep onset (95% confidence interval = [1.104, 4.459]; p = 0.001). This effect size was larger in the younger age group (aged < 44 years) stratified by median age. Higher irradiance of the blue wavelength range was significantly associated with longer wake after sleep onset, a result similar to those for the green and red wavelength ranges. Conclusion: We observed significant associations between evening light exposure and subsequent sleep in patients with bipolar disorder. The effects of various light wavelengths on sleep in bipolar disorder require further investigation.
UR - http://www.scopus.com/inward/record.url?scp=85094860745&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85094860745&partnerID=8YFLogxK
U2 - 10.1177/0004867420968886
DO - 10.1177/0004867420968886
M3 - Article
AN - SCOPUS:85094860745
VL - 55
SP - 305
EP - 313
JO - Australian and New Zealand Journal of Psychiatry
JF - Australian and New Zealand Journal of Psychiatry
SN - 0004-8674
IS - 3
ER -