Effect of exercise therapy on cytokine secretion in the Saliva of Bedridden patients

Hidemasa Iki, Shunji Sawa, Toshio Teranishi, Masao Tomita, Kazuhiro Nishii, Koji Yamada

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

[Purpose] The number of bedridden patients requiring nursing care in Japan has increased sharply in recent years because of its aging population and advances in medical care and has become a major social issue. Because bedridden patients are susceptible to nursing and healthcare-associated pneumonia, it is very important to improve their immunocompetence. Therefore, the effect of exercise therapy on stimulation of cytokine secretion in the saliva of bedridden patients was investigated. [Subjects and Methods] The subjects of this study were bedridden patients admitted to nursing care facilities. They were instructed to perform active assistive movement in the supine and sitting positions, with vital signs used as an index of the exercise load. Thirty-five patients fulfilled the inclusion criteria, which included cerebrovascular disease as the main cause of being bedridden and at least 6 months since onset. Interleukins were measured by enzyme-linked immunosorbent assay as immune mediators. [Results] Vital signs improved significantly after therapeutic exercise intervention, and the IL-6, IL-8, IL-15, and IL-17 levels also increased significantly after the intervention. [Conclusion] The results demonstrated that measurement of saliva samples may offer a safe minimally invasive method of measuring immune response in bedridden patients. This study suggests that exercise therapy may hold promise as an effective means of improving immunity in bedridden patients and may contribute to preventing aspiration pneumonia and promoting spontaneous recovery.

Original languageEnglish
Pages (from-to)2871-2876
Number of pages6
JournalJournal of Physical Therapy Science
Volume28
Issue number10
DOIs
Publication statusPublished - 01-10-2016

Fingerprint

Exercise Therapy
Saliva
Cytokines
Vital Signs
Nursing Care
Exercise
Immunocompetence
Cerebrovascular Disorders
Aspiration Pneumonia
Interleukin-15
Interleukin-17
Interleukins
Supine Position
Posture
Interleukin-8
Immunity
Interleukin-6
Pneumonia
Japan
Nursing

All Science Journal Classification (ASJC) codes

  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Iki, Hidemasa ; Sawa, Shunji ; Teranishi, Toshio ; Tomita, Masao ; Nishii, Kazuhiro ; Yamada, Koji. / Effect of exercise therapy on cytokine secretion in the Saliva of Bedridden patients. In: Journal of Physical Therapy Science. 2016 ; Vol. 28, No. 10. pp. 2871-2876.
@article{330dc3ceaee44106b6095448734fe5d3,
title = "Effect of exercise therapy on cytokine secretion in the Saliva of Bedridden patients",
abstract = "[Purpose] The number of bedridden patients requiring nursing care in Japan has increased sharply in recent years because of its aging population and advances in medical care and has become a major social issue. Because bedridden patients are susceptible to nursing and healthcare-associated pneumonia, it is very important to improve their immunocompetence. Therefore, the effect of exercise therapy on stimulation of cytokine secretion in the saliva of bedridden patients was investigated. [Subjects and Methods] The subjects of this study were bedridden patients admitted to nursing care facilities. They were instructed to perform active assistive movement in the supine and sitting positions, with vital signs used as an index of the exercise load. Thirty-five patients fulfilled the inclusion criteria, which included cerebrovascular disease as the main cause of being bedridden and at least 6 months since onset. Interleukins were measured by enzyme-linked immunosorbent assay as immune mediators. [Results] Vital signs improved significantly after therapeutic exercise intervention, and the IL-6, IL-8, IL-15, and IL-17 levels also increased significantly after the intervention. [Conclusion] The results demonstrated that measurement of saliva samples may offer a safe minimally invasive method of measuring immune response in bedridden patients. This study suggests that exercise therapy may hold promise as an effective means of improving immunity in bedridden patients and may contribute to preventing aspiration pneumonia and promoting spontaneous recovery.",
author = "Hidemasa Iki and Shunji Sawa and Toshio Teranishi and Masao Tomita and Kazuhiro Nishii and Koji Yamada",
year = "2016",
month = "10",
day = "1",
doi = "10.1589/jpts.28.2871",
language = "English",
volume = "28",
pages = "2871--2876",
journal = "Journal of Physical Therapy Science",
issn = "0915-5287",
publisher = "Society of Physical Therapy Science (Rigaku Ryoho Kagakugakkai)",
number = "10",

}

Effect of exercise therapy on cytokine secretion in the Saliva of Bedridden patients. / Iki, Hidemasa; Sawa, Shunji; Teranishi, Toshio; Tomita, Masao; Nishii, Kazuhiro; Yamada, Koji.

In: Journal of Physical Therapy Science, Vol. 28, No. 10, 01.10.2016, p. 2871-2876.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Effect of exercise therapy on cytokine secretion in the Saliva of Bedridden patients

AU - Iki, Hidemasa

AU - Sawa, Shunji

AU - Teranishi, Toshio

AU - Tomita, Masao

AU - Nishii, Kazuhiro

AU - Yamada, Koji

PY - 2016/10/1

Y1 - 2016/10/1

N2 - [Purpose] The number of bedridden patients requiring nursing care in Japan has increased sharply in recent years because of its aging population and advances in medical care and has become a major social issue. Because bedridden patients are susceptible to nursing and healthcare-associated pneumonia, it is very important to improve their immunocompetence. Therefore, the effect of exercise therapy on stimulation of cytokine secretion in the saliva of bedridden patients was investigated. [Subjects and Methods] The subjects of this study were bedridden patients admitted to nursing care facilities. They were instructed to perform active assistive movement in the supine and sitting positions, with vital signs used as an index of the exercise load. Thirty-five patients fulfilled the inclusion criteria, which included cerebrovascular disease as the main cause of being bedridden and at least 6 months since onset. Interleukins were measured by enzyme-linked immunosorbent assay as immune mediators. [Results] Vital signs improved significantly after therapeutic exercise intervention, and the IL-6, IL-8, IL-15, and IL-17 levels also increased significantly after the intervention. [Conclusion] The results demonstrated that measurement of saliva samples may offer a safe minimally invasive method of measuring immune response in bedridden patients. This study suggests that exercise therapy may hold promise as an effective means of improving immunity in bedridden patients and may contribute to preventing aspiration pneumonia and promoting spontaneous recovery.

AB - [Purpose] The number of bedridden patients requiring nursing care in Japan has increased sharply in recent years because of its aging population and advances in medical care and has become a major social issue. Because bedridden patients are susceptible to nursing and healthcare-associated pneumonia, it is very important to improve their immunocompetence. Therefore, the effect of exercise therapy on stimulation of cytokine secretion in the saliva of bedridden patients was investigated. [Subjects and Methods] The subjects of this study were bedridden patients admitted to nursing care facilities. They were instructed to perform active assistive movement in the supine and sitting positions, with vital signs used as an index of the exercise load. Thirty-five patients fulfilled the inclusion criteria, which included cerebrovascular disease as the main cause of being bedridden and at least 6 months since onset. Interleukins were measured by enzyme-linked immunosorbent assay as immune mediators. [Results] Vital signs improved significantly after therapeutic exercise intervention, and the IL-6, IL-8, IL-15, and IL-17 levels also increased significantly after the intervention. [Conclusion] The results demonstrated that measurement of saliva samples may offer a safe minimally invasive method of measuring immune response in bedridden patients. This study suggests that exercise therapy may hold promise as an effective means of improving immunity in bedridden patients and may contribute to preventing aspiration pneumonia and promoting spontaneous recovery.

UR - http://www.scopus.com/inward/record.url?scp=84992630811&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84992630811&partnerID=8YFLogxK

U2 - 10.1589/jpts.28.2871

DO - 10.1589/jpts.28.2871

M3 - Article

AN - SCOPUS:84992630811

VL - 28

SP - 2871

EP - 2876

JO - Journal of Physical Therapy Science

JF - Journal of Physical Therapy Science

SN - 0915-5287

IS - 10

ER -