Effect of high salt diet and Helicobacter pylori infection on gastric carcinogenesis

Koji Nozaki, Tetsuya Tsukamoto, Masae Tatematsu

Research output: Contribution to journalReview articlepeer-review

8 Citations (Scopus)


Helicobacter pylori(Hp) infection and a high salt diet are considered important enhancing factors in gastric carcinogenesis. A high salt diet is considered to cause temporary tissue damage, alteration of the viscosity of the protective mucous barrier, and to facilitate colonization of Hp, resulting in gastric tumor progression. The high prevalence of Hp infection and high salt diets might have greatly affected the rates of gastric carcinogenesis, especially in Japan. In Mongolian gerbils treated with a chemical carcinogen, the highest incidence of adenocarcinoma was observed in animals with both a high salt diet and Hp infection. The two factors of Hp infection and a high salt might interact to produce gastric cancers, and thus have implications for cancer prevention.

Original languageEnglish
Pages (from-to)36-40
Number of pages5
JournalNippon rinsho. Japanese journal of clinical medicine
Issue number1
Publication statusPublished - 01-2003
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General Medicine


Dive into the research topics of 'Effect of high salt diet and Helicobacter pylori infection on gastric carcinogenesis'. Together they form a unique fingerprint.

Cite this