Effect of intensive insulin therapy using a closed-loop glycemic control system in hepatic resection patients: A prospective randomized clinical trial

Takehiro Okabayashi, Isao Nishimori, Hiromichi Maeda, Koichi Yamashita, Tomoaki Yatabe, Kazuhiro Hanazaki

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

OBJECTIVE - Intensive insulin therapy (IIT) reduces morbidity and mortality in patients in surgical intensive care units. The aim of this study is to assess the effect of IIT using a closed-loop system in hepatectomized patients. RESEARCH DESIGN AND METHODS - Patients were randomly assigned to receive IIT using a closed-loop system: an artificial pancreas (AP group) or conventional insulin therapy using the sliding-scale method (SS group). RESULTS - The incidence of surgical-site infection in the AP group was significantly lower than that in the SS group. The length of hospitalization required for patients in the AP group was significantly shorter than that in the SS group. CONCLUSIONS - Total hospital costs for patients in the AP group were significantly lower than for patients in the SS group. IIT using a closed-loop system maintained near-normoglycemia and contributed to a reduction in the incidence of SSI and total hospital costs due to shortened hospitalization.

Original languageEnglish
Pages (from-to)1425-1427
Number of pages3
JournalDiabetes care
Volume32
Issue number8
DOIs
Publication statusPublished - 01-08-2009
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Advanced and Specialised Nursing

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