Effect of intermittent treatment with human parathyroid hormone 1-34 in SAMP6 senescence-accelerated mice

Y. Washimi, H. Chen, A. Ito, R. Takao, T. Uzawa, Y. Yamamoto, Harumoto Yamada, S. Shoumura

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

We examined trabecular and cortical bone in the senescence-accelerated mouse prone 6 (SAMP6) murine model of senile osteoporosis after treatment with human PTH 1-34. Sixteen-week-old female SAMP6 mice were assigned to control and PTH groups. PTH (20 μg/kg) was administered sc 3 times a week for 12 weeks. The control mouse strain, senescence-accelerated mouse resistant 1 (SAMR1), was used for comparison. The femoral metaphysis and diaphysis were used to measure bone mineral density (BMD), analyze the trabecular and the cortical structure by micro-computed tomography, and for conducting the bone strength test. PTH significantly attenuated the loss of BMD, improved the trabecular bone microstructure, and increased the bone strength in the femoral metaphysis. We did not find any differences in the bone strength of the femoral diaphysis after PTH treatment, although the cortical bone volume and cortical thickness were improved. Although the cortical thickness increased, the cortical bone density decreased, likely because of the increase of cortical porosity in the distal metaphysis after administration of PTH.

Original languageEnglish
Pages (from-to)395-400
Number of pages6
JournalJournal of Endocrinological Investigation
Volume33
Issue number6
DOIs
Publication statusPublished - 01-01-2010

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Teriparatide
Thigh
Bone Density
Diaphyses
Bone and Bones
Porosity
Parathyroid Hormone
Osteoporosis
Tomography
Control Groups
Cortical Bone

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Washimi, Y. ; Chen, H. ; Ito, A. ; Takao, R. ; Uzawa, T. ; Yamamoto, Y. ; Yamada, Harumoto ; Shoumura, S. / Effect of intermittent treatment with human parathyroid hormone 1-34 in SAMP6 senescence-accelerated mice. In: Journal of Endocrinological Investigation. 2010 ; Vol. 33, No. 6. pp. 395-400.
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Effect of intermittent treatment with human parathyroid hormone 1-34 in SAMP6 senescence-accelerated mice. / Washimi, Y.; Chen, H.; Ito, A.; Takao, R.; Uzawa, T.; Yamamoto, Y.; Yamada, Harumoto; Shoumura, S.

In: Journal of Endocrinological Investigation, Vol. 33, No. 6, 01.01.2010, p. 395-400.

Research output: Contribution to journalArticle

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AU - Washimi, Y.

AU - Chen, H.

AU - Ito, A.

AU - Takao, R.

AU - Uzawa, T.

AU - Yamamoto, Y.

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AU - Shoumura, S.

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