TY - JOUR
T1 - Effect of intraoperative needle biopsy on the survival of nonsmall cell lung cancer patients
T2 - a propensity score matching analysis
AU - Morota, Mizuki
AU - Nagano, Masaaki
AU - Ijiri, Naohiro
AU - Yoshiyasu, Nobuyuki
AU - Shinohara, Yoshikazu
AU - Nobori, Yuya
AU - Yamaguchi, Hirokazu
AU - Kawashima, Shun
AU - Yanagiya, Masahiro
AU - Konoeda, Chihiro
AU - Kitano, Kentaro
AU - Sato, Masaaki
AU - Nakajima, Jun
N1 - Publisher Copyright:
© 2022, The Author(s).
PY - 2022/10
Y1 - 2022/10
N2 - Purpose: It is unknown whether intraoperative needle biopsy (INB) predisposes to the postoperative recurrence of lung cancer and compromises the prognosis of these patients. We conducted this study to identify the effect of INB before lobectomy on the postoperative recurrence rate and prognosis of patients with nonsmall cell lung cancer (NSCLC). Methods: The subjects of this retrospective study were 953 patients with pathological stage I–III NSCLC who underwent lobectomy between 2001 and 2016. The patients were divided into two groups: the INB group (n = 94) and the non-INB group (n = 859). After propensity score matching (PSM), we compared the postoperative cumulative recurrence rate, recurrence-free survival (RFS), disease-specific survival (DSS), and overall survival (OS) between the two groups. Results: After PSM, 94 patient pairs were matched. The cumulative recurrence rate was significantly higher in the INB group than in the non-INB group (P = 0.01). The 5-year RFS rate was significantly lower in the INB group than in non-INB group (48% vs 68%), as were the 5-year DSS (76% vs 92%) and 5-year OS rates (67% vs 84%) (all P < 0.05). Conclusions: The findings of this analysis suggest that INB before lobectomy may increase the cumulative recurrence rate and worsen the prognosis of patients with resectable NSCLC. Thus, we believe that INB should be avoided unless a lung lesion cannot be diagnosed by another type of biopsy.
AB - Purpose: It is unknown whether intraoperative needle biopsy (INB) predisposes to the postoperative recurrence of lung cancer and compromises the prognosis of these patients. We conducted this study to identify the effect of INB before lobectomy on the postoperative recurrence rate and prognosis of patients with nonsmall cell lung cancer (NSCLC). Methods: The subjects of this retrospective study were 953 patients with pathological stage I–III NSCLC who underwent lobectomy between 2001 and 2016. The patients were divided into two groups: the INB group (n = 94) and the non-INB group (n = 859). After propensity score matching (PSM), we compared the postoperative cumulative recurrence rate, recurrence-free survival (RFS), disease-specific survival (DSS), and overall survival (OS) between the two groups. Results: After PSM, 94 patient pairs were matched. The cumulative recurrence rate was significantly higher in the INB group than in the non-INB group (P = 0.01). The 5-year RFS rate was significantly lower in the INB group than in non-INB group (48% vs 68%), as were the 5-year DSS (76% vs 92%) and 5-year OS rates (67% vs 84%) (all P < 0.05). Conclusions: The findings of this analysis suggest that INB before lobectomy may increase the cumulative recurrence rate and worsen the prognosis of patients with resectable NSCLC. Thus, we believe that INB should be avoided unless a lung lesion cannot be diagnosed by another type of biopsy.
KW - Intraoperative biopsy
KW - Lobectomy
KW - Lung cancer
KW - Needle biopsy
KW - Survival
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U2 - 10.1007/s00595-022-02484-w
DO - 10.1007/s00595-022-02484-w
M3 - Article
C2 - 35237884
AN - SCOPUS:85125448725
SN - 0941-1291
VL - 52
SP - 1497
EP - 1503
JO - Surgery Today
JF - Surgery Today
IS - 10
ER -
