Effect of Low-Density Lipoprotein Apheresis for Nephrotic Idiopathic Membranous Nephropathy as Initial Induction Therapy

Eri Koshi-Ito, Kiyomi Koike, Akihito Tanaka, Yu Watanabe, Naoki Kamegai, Hiroya Shimogushi, Hibiki Shinjo, Yasuhiro Otsuka, Daijo Inaguma, Asami Takeda

Research output: Contribution to journalArticle

Abstract

Low-density lipoprotein apheresis (LDL-A) has been used for nephrotic syndrome (NS) caused by focal segmental glomerulosclerosis in Japan. Idiopathic membranous nephropathy (iMN) can also cause treatment-resistant NS. Therefore, we investigated the effect of LDL-A during initial induction for it. This retrospective, observational, and single-center study enrolled consecutive iMN patients who received steroids from March 2000 to May 2015. We compared data between 11 patients treated with LDL-A (LDL-A group) and 27 patients without (non-LDL-A group) at baseline and 4 and 8 weeks later. Reduction rate of proteinuria and increase rate of serum albumin in LDL-A group were significantly higher than the other after 4 weeks (P = 0.036 and 0.030) and 8 weeks (P = 0.030 and <0.001), respectively. There was no adverse event caused by LDL-A and immunosuppressant dose was not significantly different. In conclusion, LDL-A may be an effective choice for initial induction of nephrotic iMN.

Original languageEnglish
JournalTherapeutic Apheresis and Dialysis
DOIs
Publication statusPublished - 01-01-2019

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Membranous Glomerulonephritis
Blood Component Removal
LDL Lipoproteins
Nephrotic Syndrome
Therapeutics
Focal Segmental Glomerulosclerosis
Immunosuppressive Agents
Proteinuria
Serum Albumin
Lipoproteins
Japan
Steroids

All Science Journal Classification (ASJC) codes

  • Hematology
  • Nephrology

Cite this

Koshi-Ito, Eri ; Koike, Kiyomi ; Tanaka, Akihito ; Watanabe, Yu ; Kamegai, Naoki ; Shimogushi, Hiroya ; Shinjo, Hibiki ; Otsuka, Yasuhiro ; Inaguma, Daijo ; Takeda, Asami. / Effect of Low-Density Lipoprotein Apheresis for Nephrotic Idiopathic Membranous Nephropathy as Initial Induction Therapy. In: Therapeutic Apheresis and Dialysis. 2019.
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Effect of Low-Density Lipoprotein Apheresis for Nephrotic Idiopathic Membranous Nephropathy as Initial Induction Therapy. / Koshi-Ito, Eri; Koike, Kiyomi; Tanaka, Akihito; Watanabe, Yu; Kamegai, Naoki; Shimogushi, Hiroya; Shinjo, Hibiki; Otsuka, Yasuhiro; Inaguma, Daijo; Takeda, Asami.

In: Therapeutic Apheresis and Dialysis, 01.01.2019.

Research output: Contribution to journalArticle

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AU - Koshi-Ito, Eri

AU - Koike, Kiyomi

AU - Tanaka, Akihito

AU - Watanabe, Yu

AU - Kamegai, Naoki

AU - Shimogushi, Hiroya

AU - Shinjo, Hibiki

AU - Otsuka, Yasuhiro

AU - Inaguma, Daijo

AU - Takeda, Asami

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Low-density lipoprotein apheresis (LDL-A) has been used for nephrotic syndrome (NS) caused by focal segmental glomerulosclerosis in Japan. Idiopathic membranous nephropathy (iMN) can also cause treatment-resistant NS. Therefore, we investigated the effect of LDL-A during initial induction for it. This retrospective, observational, and single-center study enrolled consecutive iMN patients who received steroids from March 2000 to May 2015. We compared data between 11 patients treated with LDL-A (LDL-A group) and 27 patients without (non-LDL-A group) at baseline and 4 and 8 weeks later. Reduction rate of proteinuria and increase rate of serum albumin in LDL-A group were significantly higher than the other after 4 weeks (P = 0.036 and 0.030) and 8 weeks (P = 0.030 and <0.001), respectively. There was no adverse event caused by LDL-A and immunosuppressant dose was not significantly different. In conclusion, LDL-A may be an effective choice for initial induction of nephrotic iMN.

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