Effect of menopause on bone metabolism indices and bone mineral density - Study of the usefulness of bone metabolism indices

T. Iida, F. Ishizaki, M. Hayashi, H. Ishikawa, T. Koyama, S. Sawada, N. Kishida

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Change in bone metabolism is one of the factors related to bone volume decrease, with bone volume decrease becoming remarkable for a period of ten years after menopause. Using female subjects with known dates of menopause but without past histories affecting bone mineral density, the present study was conducted to examine the effect of menopause on bone metabolism indices and bone mineral density, and also to determine the usefulness of various bone metabolism indices such as urine pyridinoline, deoxypyridinoline, and N-telopeptides of type 1 collagen. The values of these bone metabolism indices following menopause were higher than those prior to menopause, and the values of N-telopeptides of type 1 collagen showed the closest correlation to body mineral density of the lumbar vertebrae and the femur. This is because N-telopeptides of type 1 collagen have high bone specificity. It is therefore considered that N-telopeptides of type 1 collagen is the most useful as a bone metabolism index.

Original languageEnglish
Pages (from-to)91-99
Number of pages9
JournalJapanese Journal of Clinical Chemistry
Volume30
Issue number2
Publication statusPublished - 06-08-2001
Externally publishedYes

Fingerprint

Menopause
Metabolism
Bone Density
Minerals
Bone
Bone and Bones
Collagen Type I
Lumbar Vertebrae
Femur
Urine
collagen type I trimeric cross-linked peptide

All Science Journal Classification (ASJC) codes

  • Clinical Biochemistry

Cite this

Iida, T. ; Ishizaki, F. ; Hayashi, M. ; Ishikawa, H. ; Koyama, T. ; Sawada, S. ; Kishida, N. / Effect of menopause on bone metabolism indices and bone mineral density - Study of the usefulness of bone metabolism indices. In: Japanese Journal of Clinical Chemistry. 2001 ; Vol. 30, No. 2. pp. 91-99.
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Effect of menopause on bone metabolism indices and bone mineral density - Study of the usefulness of bone metabolism indices. / Iida, T.; Ishizaki, F.; Hayashi, M.; Ishikawa, H.; Koyama, T.; Sawada, S.; Kishida, N.

In: Japanese Journal of Clinical Chemistry, Vol. 30, No. 2, 06.08.2001, p. 91-99.

Research output: Contribution to journalArticle

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AU - Iida, T.

AU - Ishizaki, F.

AU - Hayashi, M.

AU - Ishikawa, H.

AU - Koyama, T.

AU - Sawada, S.

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AB - Change in bone metabolism is one of the factors related to bone volume decrease, with bone volume decrease becoming remarkable for a period of ten years after menopause. Using female subjects with known dates of menopause but without past histories affecting bone mineral density, the present study was conducted to examine the effect of menopause on bone metabolism indices and bone mineral density, and also to determine the usefulness of various bone metabolism indices such as urine pyridinoline, deoxypyridinoline, and N-telopeptides of type 1 collagen. The values of these bone metabolism indices following menopause were higher than those prior to menopause, and the values of N-telopeptides of type 1 collagen showed the closest correlation to body mineral density of the lumbar vertebrae and the femur. This is because N-telopeptides of type 1 collagen have high bone specificity. It is therefore considered that N-telopeptides of type 1 collagen is the most useful as a bone metabolism index.

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