Effect of minaprine on cycloheximide-induced amnesia in mice

Toshitaka Nabeshima; Kazuaki Kawashima; Tsutomu Kameyama

doi:10.1016/0014-2999(89)90022-8

Effect of minaprine on cycloheximide-induced amnesia in mice

Toshitaka Nabeshima, Kazuaki Kawashima, Tsutomu Kameyama

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Abstract

The effects of minaprine on cycloheximide-induced amnesia were investigated in a step-down passive avoidance task in mice. Minaprine significantly improved cycloheximide-induced amnesia. This effect was inhibited by scopolamine, but was potentiated by physostigmine. The anti-amnestic effect of minaprine on the cycloheximide-induced memory impairment was also antagonized by a serotonin (5-HT) releaser, p-chloroamphetamine, and by a 5-HT precursor, 5-hydroxytryptophan, whereas a 5-HT_1A-selective agonist, 8-hydroxy-2-(di-n-propylamino)tetralin, was inactive. The memory-improving effect of minaprine on cycloheximide-induced amnesia was potentiated by a selective 5-HT₂ antagonist, ritanserin. These results suggest that the beneficialeffect of minaprine on cycloheximide-induced amnesia may be related not only to cholinergic but also serotonergic neuronal systems (5-HT₂ receptors).

Original language	English
Pages (from-to)	249-257
Number of pages	9
Journal	European Journal of Pharmacology
Volume	169
Issue number	2-3
DOIs	https://doi.org/10.1016/0014-2999(89)90022-8
Publication status	Published - 10-10-1989
Externally published	Yes

All Science Journal Classification (ASJC) codes

Pharmacology

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10.1016/0014-2999(89)90022-8

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title = "Effect of minaprine on cycloheximide-induced amnesia in mice",

abstract = "The effects of minaprine on cycloheximide-induced amnesia were investigated in a step-down passive avoidance task in mice. Minaprine significantly improved cycloheximide-induced amnesia. This effect was inhibited by scopolamine, but was potentiated by physostigmine. The anti-amnestic effect of minaprine on the cycloheximide-induced memory impairment was also antagonized by a serotonin (5-HT) releaser, p-chloroamphetamine, and by a 5-HT precursor, 5-hydroxytryptophan, whereas a 5-HT1A-selective agonist, 8-hydroxy-2-(di-n-propylamino)tetralin, was inactive. The memory-improving effect of minaprine on cycloheximide-induced amnesia was potentiated by a selective 5-HT2 antagonist, ritanserin. These results suggest that the beneficialeffect of minaprine on cycloheximide-induced amnesia may be related not only to cholinergic but also serotonergic neuronal systems (5-HT2 receptors).",

author = "Toshitaka Nabeshima and Kazuaki Kawashima and Tsutomu Kameyama",

year = "1989",

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doi = "10.1016/0014-2999(89)90022-8",

language = "English",

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journal = "European Journal of Pharmacology",

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T1 - Effect of minaprine on cycloheximide-induced amnesia in mice

AU - Nabeshima, Toshitaka

AU - Kawashima, Kazuaki

AU - Kameyama, Tsutomu

PY - 1989/10/10

Y1 - 1989/10/10

N2 - The effects of minaprine on cycloheximide-induced amnesia were investigated in a step-down passive avoidance task in mice. Minaprine significantly improved cycloheximide-induced amnesia. This effect was inhibited by scopolamine, but was potentiated by physostigmine. The anti-amnestic effect of minaprine on the cycloheximide-induced memory impairment was also antagonized by a serotonin (5-HT) releaser, p-chloroamphetamine, and by a 5-HT precursor, 5-hydroxytryptophan, whereas a 5-HT1A-selective agonist, 8-hydroxy-2-(di-n-propylamino)tetralin, was inactive. The memory-improving effect of minaprine on cycloheximide-induced amnesia was potentiated by a selective 5-HT2 antagonist, ritanserin. These results suggest that the beneficialeffect of minaprine on cycloheximide-induced amnesia may be related not only to cholinergic but also serotonergic neuronal systems (5-HT2 receptors).

AB - The effects of minaprine on cycloheximide-induced amnesia were investigated in a step-down passive avoidance task in mice. Minaprine significantly improved cycloheximide-induced amnesia. This effect was inhibited by scopolamine, but was potentiated by physostigmine. The anti-amnestic effect of minaprine on the cycloheximide-induced memory impairment was also antagonized by a serotonin (5-HT) releaser, p-chloroamphetamine, and by a 5-HT precursor, 5-hydroxytryptophan, whereas a 5-HT1A-selective agonist, 8-hydroxy-2-(di-n-propylamino)tetralin, was inactive. The memory-improving effect of minaprine on cycloheximide-induced amnesia was potentiated by a selective 5-HT2 antagonist, ritanserin. These results suggest that the beneficialeffect of minaprine on cycloheximide-induced amnesia may be related not only to cholinergic but also serotonergic neuronal systems (5-HT2 receptors).

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U2 - 10.1016/0014-2999(89)90022-8

DO - 10.1016/0014-2999(89)90022-8

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C2 - 2530096

AN - SCOPUS:0024468959

SN - 0014-2999

VL - 169

SP - 249

EP - 257

JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

IS - 2-3

ER -

Effect of minaprine on cycloheximide-induced amnesia in mice

Abstract

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