Effect of natural killer cell infiltration on the growth of breast cancer patient-derived tumor xenografts

Junko Mukohyama, Yohei Shimono, Yohei Funakoshi, Seishi Kono, Kimihiro Yamashita, Toru Mukohara, Shintaro Takao, Hironobu Minami, Yoshihiro Kakeji

Research output: Contribution to journalArticlepeer-review

Abstract

Natural killer (NK) cells, a component of the innate immunity, play important roles in tumor suppression. In this study, three human breast cancer patient-derived tumor xenografts (PDXs), established by the transplantation of surgical specimens, were passaged in immunodeficient NOD/SCID mice or NSG mice, that further lacks NK cell activity. The intensity of the relative growth suppression between NOD/SCID and NSG mice was clearly different depending on the PDX lines, and it was associated with the intensities of the CD49b-positive NK cell infiltration in the PDX tumor tissues. However, no obvious association was observed between the mRNA expression levels of the NK cell ligands in the PDX tumor cells and the intensity of NK cell infiltration into the PDX tumors. These results suggest that the suppressive effect of NK cells on the growth of breast cancer PDX is highly variable depending on the PDX lines. Further studies are needed to elucidate the molecular mechanism of NK cell infiltration in PDX tumors.

Original languageEnglish
Pages (from-to)1252-1255
Number of pages4
JournalJapanese Journal of Cancer and Chemotherapy
Volume42
Issue number10
Publication statusPublished - 10-2015
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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