TY - JOUR
T1 - Effect of nighttime bedroom light exposure on mood episode relapses in bipolar disorder
AU - Esaki, Yuichi
AU - Obayashi, Kenji
AU - Saeki, Keigo
AU - Fujita, Kiyoshi
AU - Iwata, Nakao
AU - Kitajima, Tsuyoshi
N1 - Funding Information:
We would like to express our gratitude to the patients who participated in this study. Moreover, we would also like to thank Miyuki Yamamoto for the valuable support during the whole duration of this research and MARUZEN‐YUSHODO Co., Ltd. ( https://kw.maruzen.co.jp/kousei‐honyaku/ ) for the English language editing. This work was supported by Scientific Research from JSPS KAKENHI (grant number: 18K15529), Japan Foundation for Neuroscience and Mental Health, and the Neuroscience Research Center.
Funding Information:
The authors report no conflicts of interest related to this research. Dr. Esaki has received manuscript fees from Dainippon Sumitomo. Dr. Obayashi and Dr. Saeki received research grants from YKK AP Inc.; Ushio Inc.; Tokyo Electric Power Company; EnviroLife Research Institute Co., Ltd.; Sekisui Chemical Co., Ltd.; LIXIL Corp.; KYOCERA Corp.; ENDO Lighting Corp.; and KANEKA corp. Dr. Fujita has received speaker's honoraria from Dainippon Sumitomo, Eli Lilly, GlaxoSmithKline, Janssen, Yoshitomi, Otsuka, Meiji, Shionogi, Novartis, and Kracie. Dr. Iwata has received speaker's honoraria from Astellas, Dainippon Sumitomo, Eli Lilly, GlaxoSmithKline, Janssen, Yoshitomi, Otsuka, Meiji, Shionogi, Novartis, and Pfizer as well as research grants from GlaxoSmithKline, Meiji, Otsuka, Mitsubishi Tanabe, Dainippon Sumitomo, Daiichisankyo, and Eisai. Dr. Kitajima has received speaker's honoraria from Eisai, Mitsubishi Tanabe, Otsuka, Takeda, Eli Lilly, MSD, Meiji, Yoshitomi, Fukuda, Dainippon Sumitomo, Shionogi, and Novo Nordisk and a research grant from Eisai, MSD, and Takeda.
Funding Information:
We would like to express our gratitude to the patients who participated in this study. Moreover, we would also like to thank Miyuki Yamamoto for the valuable support during the whole duration of this research and MARUZEN-YUSHODO Co., Ltd. (https://kw.maruzen.co.jp/kousei-honyaku/) for the English language editing. This work was supported by Scientific Research from JSPS KAKENHI (grant number: 18K15529), Japan Foundation for Neuroscience and Mental Health, and the Neuroscience Research Center.
Publisher Copyright:
© 2022 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
PY - 2022/7
Y1 - 2022/7
N2 - Objective: A previous cross-sectional study reported that nighttime light is associated with increased occurrence of manic symptoms in bipolar disorder; however, the longitudinal association between nighttime light and subsequent mood episode relapses remains unclear. We determined whether bedroom nighttime light was associated with mood episode relapses in patients with bipolar disorder. Methods: This prospective cohort study included 172 outpatients with bipolar disorder who participated in an Association between the Pathology of Bipolar Disorder and Light Exposure in Daily Life (APPLE) cohort study. A portable photometer was used to measure illuminance in the bedroom from bedtime to rising time during 7 consecutive nights for baseline assessment. Then, the participants were assessed at a 2-year follow-up for mood episode relapses. Results: Of the 172 participants, 157 (91%) completed the 2-year follow-up, and 39 (22%) experienced manic or hypomanic episodes (with or without mixed features), during that time. In the Cox proportional-hazards model, the hazard ratio (HR) for manic/hypomanic episode relapses was significantly higher when the average nighttime illuminance was ≥3 lux (n = 71) than when it was <3 lux (n = 101; HR, 2.54; 95% confidence interval (CI), 1.33–4.84). In the multivariable model adjusted for a propensity score in relation to nighttime light, the relationship remained significant (HR, 2.17; 95% CI, 1.04–4.52). The association between nighttime light and depressive episode relapses was not significantly different. Conclusions: Keeping the bedroom dark at night may prevent hypomanic and manic episodes.
AB - Objective: A previous cross-sectional study reported that nighttime light is associated with increased occurrence of manic symptoms in bipolar disorder; however, the longitudinal association between nighttime light and subsequent mood episode relapses remains unclear. We determined whether bedroom nighttime light was associated with mood episode relapses in patients with bipolar disorder. Methods: This prospective cohort study included 172 outpatients with bipolar disorder who participated in an Association between the Pathology of Bipolar Disorder and Light Exposure in Daily Life (APPLE) cohort study. A portable photometer was used to measure illuminance in the bedroom from bedtime to rising time during 7 consecutive nights for baseline assessment. Then, the participants were assessed at a 2-year follow-up for mood episode relapses. Results: Of the 172 participants, 157 (91%) completed the 2-year follow-up, and 39 (22%) experienced manic or hypomanic episodes (with or without mixed features), during that time. In the Cox proportional-hazards model, the hazard ratio (HR) for manic/hypomanic episode relapses was significantly higher when the average nighttime illuminance was ≥3 lux (n = 71) than when it was <3 lux (n = 101; HR, 2.54; 95% confidence interval (CI), 1.33–4.84). In the multivariable model adjusted for a propensity score in relation to nighttime light, the relationship remained significant (HR, 2.17; 95% CI, 1.04–4.52). The association between nighttime light and depressive episode relapses was not significantly different. Conclusions: Keeping the bedroom dark at night may prevent hypomanic and manic episodes.
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U2 - 10.1111/acps.13422
DO - 10.1111/acps.13422
M3 - Article
C2 - 35253206
AN - SCOPUS:85125884614
VL - 146
SP - 64
EP - 73
JO - Acta Psychiatrica Scandinavica
JF - Acta Psychiatrica Scandinavica
SN - 0001-690X
IS - 1
ER -