Effect of Omega-3 Fatty Acids on Coronary Plaque Morphology-A Serial Computed Tomography Angiography Study

Sadako Motoyama, Yasuomi Nagahara, Masayoshi Sarai, Hideki Kawai, Keiichi Miyajima, Yoshihiro Sato, Ryota Matsumoto, Hiroshi Takahashi, Hiroyuki Naruse, Junnichi Ishii, Yukio Ozaki, Hideo Izawa

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)


Background: Omega-3 fatty acids have been proposed to be useful in the prevention of cardiac events. High-risk plaque (HRP) and plaque progression on serial coronary computed tomography angiography (CTA) have been suggested to be the predecessor of acute coronary syndrome (ACS). The purpose of this study was to investigate whether addition of omega-3 fatty acids to statin therapy for secondary prevention would lead to change in plaque characteristics detected by using serial CTA. Methods and Results: This study enrolled 210 patients with ACS: no eicosapentaenoic acid (EPA)/ docosahexaenoic acid (DHA; EPA/DHA), low-dose EPA+DHA, high-dose EPA+DHA, and high-dose EPA alone. HRP was significantly more frequent in patients with plaque progression (P=0.0001). There was a significant interaction between plaque progression and EPA dose regardless of the DHA dose; 20.3% in EPA-none (no EPA/DHA), 15.7% in EPA-low (low-dose EPA+DHA), and 5.6% in EPA-high (high-dose EPA+DHA and high-dose EPA alone). On multivariate logistic regression analysis, HRP (OR 6.44, P<0.0001), EPA-high (OR 0.13, P=0.0004), and Rosvastatin (OR 0.24, P=0.0079) were the independent predictors for plaque progression. In quantitative analyses (n=563 plaques), the interval change of low attenuation plaque (LAP) volume was significantly different based on EPA dose; LAP was significantly increased in the EPA-none group and significantly decreased in the EPA-high group. Conclusions: In patients with ACS, addition of high-dose EPA (EPA-high) to statin therapy, compared to statin therapy without EPA, was associated with a lower rate of plaque progression.

Original languageEnglish
Pages (from-to)831-842
Number of pages12
JournalCirculation Journal
Issue number5
Publication statusPublished - 2022

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine


Dive into the research topics of 'Effect of Omega-3 Fatty Acids on Coronary Plaque Morphology-A Serial Computed Tomography Angiography Study'. Together they form a unique fingerprint.

Cite this