Abstract
We studied the role of osteopontin (OPN) in host responses against rotavirus (RV) infection. OPN knockout (OPN-KO) suckling mice were more susceptible to RV (strain EW) infection and showed prolonged diarrhea duration compared to wild-type (WT) suckling mice. OPN in the small intestine of WT mice was expressed after 48 h post-infection. On day 2 postinfection, mRNA levels of interleukin-1β, tumor necrosis factor-α, and interleukin-15 in OPN-KO mice were lower than in WT mice, although mRNA expression of Th-1- and Th-2-related cytokines in the small intestine were nearly the same between OPN-KO and WT mice. These results suggested that OPN is involved in innate responses against RV infection.
Original language | English |
---|---|
Pages (from-to) | 139-144 |
Number of pages | 6 |
Journal | Viral Immunology |
Volume | 22 |
Issue number | 2 |
DOIs | |
Publication status | Published - 01-04-2009 |
All Science Journal Classification (ASJC) codes
- Immunology
- Molecular Medicine
- Virology