Effect of osteopontin on diarrhea duration and innate immunity in suckling mice infected with a murine rotavirus

Yoshimasa Maeno; Masanori Shinzato; Shigeo Nagashima; Susan R. Rittling; David T. Denhardt; Toshimitsu Uede; Koki Taniguchi

doi:10.1089/vim.2008.0054

Effect of osteopontin on diarrhea duration and innate immunity in suckling mice infected with a murine rotavirus

Yoshimasa Maeno, Masanori Shinzato, Shigeo Nagashima, Susan R. Rittling, David T. Denhardt, Toshimitsu Uede, Koki Taniguchi

Virology and Parasitology

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

We studied the role of osteopontin (OPN) in host responses against rotavirus (RV) infection. OPN knockout (OPN-KO) suckling mice were more susceptible to RV (strain EW) infection and showed prolonged diarrhea duration compared to wild-type (WT) suckling mice. OPN in the small intestine of WT mice was expressed after 48 h post-infection. On day 2 postinfection, mRNA levels of interleukin-1β, tumor necrosis factor-α, and interleukin-15 in OPN-KO mice were lower than in WT mice, although mRNA expression of Th-1- and Th-2-related cytokines in the small intestine were nearly the same between OPN-KO and WT mice. These results suggested that OPN is involved in innate responses against RV infection.

Original language	English
Pages (from-to)	139-144
Number of pages	6
Journal	Viral Immunology
Volume	22
Issue number	2
DOIs	https://doi.org/10.1089/vim.2008.0054
Publication status	Published - 01-04-2009

All Science Journal Classification (ASJC) codes

Immunology
Molecular Medicine
Virology

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10.1089/vim.2008.0054

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title = "Effect of osteopontin on diarrhea duration and innate immunity in suckling mice infected with a murine rotavirus",

abstract = "We studied the role of osteopontin (OPN) in host responses against rotavirus (RV) infection. OPN knockout (OPN-KO) suckling mice were more susceptible to RV (strain EW) infection and showed prolonged diarrhea duration compared to wild-type (WT) suckling mice. OPN in the small intestine of WT mice was expressed after 48 h post-infection. On day 2 postinfection, mRNA levels of interleukin-1β, tumor necrosis factor-α, and interleukin-15 in OPN-KO mice were lower than in WT mice, although mRNA expression of Th-1- and Th-2-related cytokines in the small intestine were nearly the same between OPN-KO and WT mice. These results suggested that OPN is involved in innate responses against RV infection.",

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AU - Maeno, Yoshimasa

AU - Shinzato, Masanori

AU - Nagashima, Shigeo

AU - Rittling, Susan R.

AU - Denhardt, David T.

AU - Uede, Toshimitsu

AU - Taniguchi, Koki

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Effect of osteopontin on diarrhea duration and innate immunity in suckling mice infected with a murine rotavirus

Abstract

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