Effect of osteopontin on diarrhea duration and innate immunity in suckling mice infected with a murine rotavirus

Yoshimasa Maeno, Masanori Shinzato, Shigeo Nagashima, Susan R. Rittling, David T. Denhardt, Toshimitsu Uede, Koki Taniguchi

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

We studied the role of osteopontin (OPN) in host responses against rotavirus (RV) infection. OPN knockout (OPN-KO) suckling mice were more susceptible to RV (strain EW) infection and showed prolonged diarrhea duration compared to wild-type (WT) suckling mice. OPN in the small intestine of WT mice was expressed after 48 h post-infection. On day 2 postinfection, mRNA levels of interleukin-1β, tumor necrosis factor-α, and interleukin-15 in OPN-KO mice were lower than in WT mice, although mRNA expression of Th-1- and Th-2-related cytokines in the small intestine were nearly the same between OPN-KO and WT mice. These results suggested that OPN is involved in innate responses against RV infection.

Original languageEnglish
Pages (from-to)139-144
Number of pages6
JournalViral Immunology
Volume22
Issue number2
DOIs
Publication statusPublished - 01-04-2009

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Osteopontin
Rotavirus
Innate Immunity
Diarrhea
Rotavirus Infections
Small Intestine
Interleukin-15
Messenger RNA
Infection
Interleukin-1
Knockout Mice
Tumor Necrosis Factor-alpha
Cytokines

All Science Journal Classification (ASJC) codes

  • Immunology
  • Molecular Medicine
  • Virology

Cite this

Maeno, Y., Shinzato, M., Nagashima, S., Rittling, S. R., Denhardt, D. T., Uede, T., & Taniguchi, K. (2009). Effect of osteopontin on diarrhea duration and innate immunity in suckling mice infected with a murine rotavirus. Viral Immunology, 22(2), 139-144. https://doi.org/10.1089/vim.2008.0054
Maeno, Yoshimasa ; Shinzato, Masanori ; Nagashima, Shigeo ; Rittling, Susan R. ; Denhardt, David T. ; Uede, Toshimitsu ; Taniguchi, Koki. / Effect of osteopontin on diarrhea duration and innate immunity in suckling mice infected with a murine rotavirus. In: Viral Immunology. 2009 ; Vol. 22, No. 2. pp. 139-144.
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Maeno, Y, Shinzato, M, Nagashima, S, Rittling, SR, Denhardt, DT, Uede, T & Taniguchi, K 2009, 'Effect of osteopontin on diarrhea duration and innate immunity in suckling mice infected with a murine rotavirus', Viral Immunology, vol. 22, no. 2, pp. 139-144. https://doi.org/10.1089/vim.2008.0054

Effect of osteopontin on diarrhea duration and innate immunity in suckling mice infected with a murine rotavirus. / Maeno, Yoshimasa; Shinzato, Masanori; Nagashima, Shigeo; Rittling, Susan R.; Denhardt, David T.; Uede, Toshimitsu; Taniguchi, Koki.

In: Viral Immunology, Vol. 22, No. 2, 01.04.2009, p. 139-144.

Research output: Contribution to journalArticle

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