Effect of osteopontin on diarrhea duration and innate immunity in suckling mice infected with a murine rotavirus

Yoshimasa Maeno, Masanori Shinzato, Shigeo Nagashima, Susan R. Rittling, David T. Denhardt, Toshimitsu Uede, Koki Taniguchi

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

We studied the role of osteopontin (OPN) in host responses against rotavirus (RV) infection. OPN knockout (OPN-KO) suckling mice were more susceptible to RV (strain EW) infection and showed prolonged diarrhea duration compared to wild-type (WT) suckling mice. OPN in the small intestine of WT mice was expressed after 48 h post-infection. On day 2 postinfection, mRNA levels of interleukin-1β, tumor necrosis factor-α, and interleukin-15 in OPN-KO mice were lower than in WT mice, although mRNA expression of Th-1- and Th-2-related cytokines in the small intestine were nearly the same between OPN-KO and WT mice. These results suggested that OPN is involved in innate responses against RV infection.

Original languageEnglish
Pages (from-to)139-144
Number of pages6
JournalViral Immunology
Volume22
Issue number2
DOIs
Publication statusPublished - 01-04-2009

All Science Journal Classification (ASJC) codes

  • Immunology
  • Molecular Medicine
  • Virology

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