Abstract
We studied the role of osteopontin (OPN) in host responses against rotavirus (RV) infection. OPN knockout (OPN-KO) suckling mice were more susceptible to RV (strain EW) infection and showed prolonged diarrhea duration compared to wild-type (WT) suckling mice. OPN in the small intestine of WT mice was expressed after 48 h post-infection. On day 2 postinfection, mRNA levels of interleukin-1β, tumor necrosis factor-α, and interleukin-15 in OPN-KO mice were lower than in WT mice, although mRNA expression of Th-1- and Th-2-related cytokines in the small intestine were nearly the same between OPN-KO and WT mice. These results suggested that OPN is involved in innate responses against RV infection.
| Original language | English |
|---|---|
| Pages (from-to) | 139-144 |
| Number of pages | 6 |
| Journal | Viral Immunology |
| Volume | 22 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 01-04-2009 |
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All Science Journal Classification (ASJC) codes
- Immunology
- Molecular Medicine
- Virology
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Effect of osteopontin on diarrhea duration and innate immunity in suckling mice infected with a murine rotavirus. / Maeno, Yoshimasa; Shinzato, Masanori; Nagashima, Shigeo; Rittling, Susan R.; Denhardt, David T.; Uede, Toshimitsu; Taniguchi, Koki.
In: Viral Immunology, Vol. 22, No. 2, 01.04.2009, p. 139-144.Research output: Contribution to journal › Article
TY - JOUR
T1 - Effect of osteopontin on diarrhea duration and innate immunity in suckling mice infected with a murine rotavirus
AU - Maeno, Yoshimasa
AU - Shinzato, Masanori
AU - Nagashima, Shigeo
AU - Rittling, Susan R.
AU - Denhardt, David T.
AU - Uede, Toshimitsu
AU - Taniguchi, Koki
PY - 2009/4/1
Y1 - 2009/4/1
N2 - We studied the role of osteopontin (OPN) in host responses against rotavirus (RV) infection. OPN knockout (OPN-KO) suckling mice were more susceptible to RV (strain EW) infection and showed prolonged diarrhea duration compared to wild-type (WT) suckling mice. OPN in the small intestine of WT mice was expressed after 48 h post-infection. On day 2 postinfection, mRNA levels of interleukin-1β, tumor necrosis factor-α, and interleukin-15 in OPN-KO mice were lower than in WT mice, although mRNA expression of Th-1- and Th-2-related cytokines in the small intestine were nearly the same between OPN-KO and WT mice. These results suggested that OPN is involved in innate responses against RV infection.
AB - We studied the role of osteopontin (OPN) in host responses against rotavirus (RV) infection. OPN knockout (OPN-KO) suckling mice were more susceptible to RV (strain EW) infection and showed prolonged diarrhea duration compared to wild-type (WT) suckling mice. OPN in the small intestine of WT mice was expressed after 48 h post-infection. On day 2 postinfection, mRNA levels of interleukin-1β, tumor necrosis factor-α, and interleukin-15 in OPN-KO mice were lower than in WT mice, although mRNA expression of Th-1- and Th-2-related cytokines in the small intestine were nearly the same between OPN-KO and WT mice. These results suggested that OPN is involved in innate responses against RV infection.
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UR - http://www.scopus.com/inward/citedby.url?scp=65249117368&partnerID=8YFLogxK
U2 - 10.1089/vim.2008.0054
DO - 10.1089/vim.2008.0054
M3 - Article
C2 - 19327001
AN - SCOPUS:65249117368
VL - 22
SP - 139
EP - 144
JO - Viral Immunology
JF - Viral Immunology
SN - 0882-8245
IS - 2
ER -