Effect of physical activity on breast cancer risk: Findings of the Japan collaborative cohort study

Sadao Suzuki, Masayo Kojima, Shinkan Tokudome, Mitsuru Mori, Fumio Sakauchi, Yoshihisa Fujino, Kenji Wakai, Yingsong Lin, Shogo Kikuchi, Koji Tamakoshi, Hiroshi Yatsuya, Akiko Tamakoshi

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Purpose: This study aimed to examine prospectively the association between physical activity and breast cancer risk in a non-Western population. Methods: We analyzed data from the Japan Collaborative Cohort Study, which included 30,157 women, ages 40 to 69 years at baseline (1988-1990), who reported no previous history of breast cancer, and provided information on their walking and exercise habits. The subjects were followed prospectively from enrollment until 2001 (median follow-up period, 12.4 years). Breast cancer incidence during this period was confirmed using records held at population-based cancer registries. The Cox proportional hazards model was used to estimate the hazard ratio (HR) for the association of breast cancer incidence with physical activity. Results: During the 340,055 person-years of follow-up, we identified 207 incident cases of breast cancer. The most physically active group (who walked for ≥1 hour per day and exercised for ≥1 hour per week) had a lower risk of breast cancer (HR, 0.45; 95% confidence interval, 0.25-0.78) compared with the least active group after adjusting for potential confounding factors. The inverse association of exercise on breast cancer was stronger among those who walked for ≥1 hour per day than those who walked for <1 hour per day (P = 0.042). These results were not significantly modified by menopausal status or body mass index (BMI). Conclusions: Our analysis provided evidence that physical activity decreased the risk of breast cancer. Walking for 1 hour per day and undertaking additional weekly exercise both seemed to be protective against breast cancer, regardless of menopausal status or BMI.

Original languageEnglish
Pages (from-to)3396-3401
Number of pages6
JournalCancer Epidemiology Biomarkers and Prevention
Volume17
Issue number12
DOIs
Publication statusPublished - 01-12-2008

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Japan
Cohort Studies
Exercise
Breast Neoplasms
Walking
Body Mass Index
Incidence
Proportional Hazards Models
Population
Habits
Registries
Confidence Intervals
Neoplasms

All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Oncology

Cite this

Suzuki, Sadao ; Kojima, Masayo ; Tokudome, Shinkan ; Mori, Mitsuru ; Sakauchi, Fumio ; Fujino, Yoshihisa ; Wakai, Kenji ; Lin, Yingsong ; Kikuchi, Shogo ; Tamakoshi, Koji ; Yatsuya, Hiroshi ; Tamakoshi, Akiko. / Effect of physical activity on breast cancer risk : Findings of the Japan collaborative cohort study. In: Cancer Epidemiology Biomarkers and Prevention. 2008 ; Vol. 17, No. 12. pp. 3396-3401.
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abstract = "Purpose: This study aimed to examine prospectively the association between physical activity and breast cancer risk in a non-Western population. Methods: We analyzed data from the Japan Collaborative Cohort Study, which included 30,157 women, ages 40 to 69 years at baseline (1988-1990), who reported no previous history of breast cancer, and provided information on their walking and exercise habits. The subjects were followed prospectively from enrollment until 2001 (median follow-up period, 12.4 years). Breast cancer incidence during this period was confirmed using records held at population-based cancer registries. The Cox proportional hazards model was used to estimate the hazard ratio (HR) for the association of breast cancer incidence with physical activity. Results: During the 340,055 person-years of follow-up, we identified 207 incident cases of breast cancer. The most physically active group (who walked for ≥1 hour per day and exercised for ≥1 hour per week) had a lower risk of breast cancer (HR, 0.45; 95{\%} confidence interval, 0.25-0.78) compared with the least active group after adjusting for potential confounding factors. The inverse association of exercise on breast cancer was stronger among those who walked for ≥1 hour per day than those who walked for <1 hour per day (P = 0.042). These results were not significantly modified by menopausal status or body mass index (BMI). Conclusions: Our analysis provided evidence that physical activity decreased the risk of breast cancer. Walking for 1 hour per day and undertaking additional weekly exercise both seemed to be protective against breast cancer, regardless of menopausal status or BMI.",
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Suzuki, S, Kojima, M, Tokudome, S, Mori, M, Sakauchi, F, Fujino, Y, Wakai, K, Lin, Y, Kikuchi, S, Tamakoshi, K, Yatsuya, H & Tamakoshi, A 2008, 'Effect of physical activity on breast cancer risk: Findings of the Japan collaborative cohort study', Cancer Epidemiology Biomarkers and Prevention, vol. 17, no. 12, pp. 3396-3401. https://doi.org/10.1158/1055-9965.EPI-08-0497

Effect of physical activity on breast cancer risk : Findings of the Japan collaborative cohort study. / Suzuki, Sadao; Kojima, Masayo; Tokudome, Shinkan; Mori, Mitsuru; Sakauchi, Fumio; Fujino, Yoshihisa; Wakai, Kenji; Lin, Yingsong; Kikuchi, Shogo; Tamakoshi, Koji; Yatsuya, Hiroshi; Tamakoshi, Akiko.

In: Cancer Epidemiology Biomarkers and Prevention, Vol. 17, No. 12, 01.12.2008, p. 3396-3401.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Effect of physical activity on breast cancer risk

T2 - Findings of the Japan collaborative cohort study

AU - Suzuki, Sadao

AU - Kojima, Masayo

AU - Tokudome, Shinkan

AU - Mori, Mitsuru

AU - Sakauchi, Fumio

AU - Fujino, Yoshihisa

AU - Wakai, Kenji

AU - Lin, Yingsong

AU - Kikuchi, Shogo

AU - Tamakoshi, Koji

AU - Yatsuya, Hiroshi

AU - Tamakoshi, Akiko

PY - 2008/12/1

Y1 - 2008/12/1

N2 - Purpose: This study aimed to examine prospectively the association between physical activity and breast cancer risk in a non-Western population. Methods: We analyzed data from the Japan Collaborative Cohort Study, which included 30,157 women, ages 40 to 69 years at baseline (1988-1990), who reported no previous history of breast cancer, and provided information on their walking and exercise habits. The subjects were followed prospectively from enrollment until 2001 (median follow-up period, 12.4 years). Breast cancer incidence during this period was confirmed using records held at population-based cancer registries. The Cox proportional hazards model was used to estimate the hazard ratio (HR) for the association of breast cancer incidence with physical activity. Results: During the 340,055 person-years of follow-up, we identified 207 incident cases of breast cancer. The most physically active group (who walked for ≥1 hour per day and exercised for ≥1 hour per week) had a lower risk of breast cancer (HR, 0.45; 95% confidence interval, 0.25-0.78) compared with the least active group after adjusting for potential confounding factors. The inverse association of exercise on breast cancer was stronger among those who walked for ≥1 hour per day than those who walked for <1 hour per day (P = 0.042). These results were not significantly modified by menopausal status or body mass index (BMI). Conclusions: Our analysis provided evidence that physical activity decreased the risk of breast cancer. Walking for 1 hour per day and undertaking additional weekly exercise both seemed to be protective against breast cancer, regardless of menopausal status or BMI.

AB - Purpose: This study aimed to examine prospectively the association between physical activity and breast cancer risk in a non-Western population. Methods: We analyzed data from the Japan Collaborative Cohort Study, which included 30,157 women, ages 40 to 69 years at baseline (1988-1990), who reported no previous history of breast cancer, and provided information on their walking and exercise habits. The subjects were followed prospectively from enrollment until 2001 (median follow-up period, 12.4 years). Breast cancer incidence during this period was confirmed using records held at population-based cancer registries. The Cox proportional hazards model was used to estimate the hazard ratio (HR) for the association of breast cancer incidence with physical activity. Results: During the 340,055 person-years of follow-up, we identified 207 incident cases of breast cancer. The most physically active group (who walked for ≥1 hour per day and exercised for ≥1 hour per week) had a lower risk of breast cancer (HR, 0.45; 95% confidence interval, 0.25-0.78) compared with the least active group after adjusting for potential confounding factors. The inverse association of exercise on breast cancer was stronger among those who walked for ≥1 hour per day than those who walked for <1 hour per day (P = 0.042). These results were not significantly modified by menopausal status or body mass index (BMI). Conclusions: Our analysis provided evidence that physical activity decreased the risk of breast cancer. Walking for 1 hour per day and undertaking additional weekly exercise both seemed to be protective against breast cancer, regardless of menopausal status or BMI.

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