Effect of PMX-DHP for sepsis due to ESBL-producing E. coli in an extremely low-birthweight infant

Naoto Nishizaki, Mayu Nakagawa, Satoshi Hara, Hisayuki Oda, Masato Kantake, Kaoru Obinata, Yuki Uehara, Keiichi Hiramatsu, Toshiaki Shimizu

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)

Abstract

We report a case of early onset sepsis caused by (CTX for cefotaximase and M for Munich)-type extended-spectrum β-lactamase-producing Escherichia coli (ESBL E. coli) in a preterm infant weighing 601 g. He was given meropenem and treated for endotoxin absorption with polymyxin B-immobilized fibers with only 8 mL of priming volume. The patient survived without any short-term neurological or respiratory sequelae. The choice of antibiotics is particularly important in seriously ill neonates with sepsis due to ESBL-producing organisms. Polymyxin B hemoperfusion might be an innovative therapy for severe neonatal sepsis and could improve outcome even in an extremely low-birthweight infant.

Original languageEnglish
Pages (from-to)411-414
Number of pages4
JournalPediatrics International
Volume58
Issue number5
DOIs
Publication statusPublished - 01-05-2016
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health

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