Effect of polymorphisms in the 3′-untranslated region (3′-UTR) of VEGF gene on gastric pre-malignant condition

Tomomitsu Tahara, Omiyasu Arisawa, Tomoyuki Shibata, Masakatsu Nakamura, Hiromi Yamashita, Daisuke Yoshioka, Masaaki Okubo, Naoko Maruyama, Toshiaki Kamano, Yoshio Kamiya, Hiroshi Fujita, Mitsuo Nagasaka, Masami Iwata, Kazuya Takahama, Akoto Watanabe, Hiroshi Nakano, Ichiro Hirata

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

Background: A complex interaction of host genetic and environmental factors may be relevant in Helicocobacter pylori-related gastric carcinogenesis. We investigated the effect of VEGF gene polymorphisms on the risk of gastric pre-malignant condition. Patients and Methods: The G1612A and C936T polymorphisms in the 3'-untranslated region (3'-UTR) of the VEGF gene were genotyped in 337 cancer-free individuals. The presence of intestinal metaplasia in the gastric antrum was assesed in all. Gastritis scores were also assessed according to the updated Sydney system. Results: The 1612 GA genotype held a significantly higher incidence of intestinal metaplasia in H. pylori-positive individuals more than 65 years of age (OR=4.05, 95% CI=1.08-15.15, p=0.038). The degree of intestinal metaplasia was also higher among individuals with 1612 GA in the same generation (GG vs. GA; 0.98±0.87 vs. 1.55±0.96, p=0.026). Conclusion: The G1612A but not the C936T polymorphism of the VEGF gene is associated with gastric pre-malignant condition in older individuals.

Original languageEnglish
Pages (from-to)485-489
Number of pages5
JournalAnticancer research
Volume29
Issue number2
Publication statusPublished - 02-2009

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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