Effect of polymorphisms in the 3′-untranslated region (3′-UTR) of VEGF gene on gastric pre-malignant condition

Tomomitsu Tahara; Omiyasu Arisawa; Tomoyuki Shibata; Masakatsu Nakamura; Hiromi Yamashita; Daisuke Yoshioka; Masaaki Okubo; Naoko Maruyama; Toshiaki Kamano; Yoshio Kamiya; Hiroshi Fujita; Mitsuo Nagasaka; Masami Iwata; Kazuya Takahama; Akoto Watanabe; Hiroshi Nakano; Ichiro Hirata

Effect of polymorphisms in the 3′-untranslated region (3′-UTR) of VEGF gene on gastric pre-malignant condition

Tomomitsu Tahara, Omiyasu Arisawa, Tomoyuki Shibata, Masakatsu Nakamura, Hiromi Yamashita, Daisuke Yoshioka, Masaaki Okubo, Naoko Maruyama, Toshiaki Kamano, Yoshio Kamiya, Hiroshi Fujita, Mitsuo Nagasaka, Masami Iwata, Kazuya Takahama, Akoto Watanabe, Hiroshi Nakano, Ichiro Hirata

Internal Medicine

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

Background: A complex interaction of host genetic and environmental factors may be relevant in Helicocobacter pylori-related gastric carcinogenesis. We investigated the effect of VEGF gene polymorphisms on the risk of gastric pre-malignant condition. Patients and Methods: The G1612A and C936T polymorphisms in the 3'-untranslated region (3'-UTR) of the VEGF gene were genotyped in 337 cancer-free individuals. The presence of intestinal metaplasia in the gastric antrum was assesed in all. Gastritis scores were also assessed according to the updated Sydney system. Results: The 1612 GA genotype held a significantly higher incidence of intestinal metaplasia in H. pylori-positive individuals more than 65 years of age (OR=4.05, 95% CI=1.08-15.15, p=0.038). The degree of intestinal metaplasia was also higher among individuals with 1612 GA in the same generation (GG vs. GA; 0.98±0.87 vs. 1.55±0.96, p=0.026). Conclusion: The G1612A but not the C936T polymorphism of the VEGF gene is associated with gastric pre-malignant condition in older individuals.

Original language	English
Pages (from-to)	485-489
Number of pages	5
Journal	Anticancer research
Volume	29
Issue number	2
Publication status	Published - 02-2009

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Tahara, T., Arisawa, O., Shibata, T., Nakamura, M., Yamashita, H., Yoshioka, D., Okubo, M., Maruyama, N., Kamano, T., Kamiya, Y., Fujita, H., Nagasaka, M., Iwata, M., Takahama, K., Watanabe, A., Nakano, H., & Hirata, I. (2009). Effect of polymorphisms in the 3′-untranslated region (3′-UTR) of VEGF gene on gastric pre-malignant condition. Anticancer research, 29(2), 485-489.

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title = "Effect of polymorphisms in the 3′-untranslated region (3′-UTR) of VEGF gene on gastric pre-malignant condition",

abstract = "Background: A complex interaction of host genetic and environmental factors may be relevant in Helicocobacter pylori-related gastric carcinogenesis. We investigated the effect of VEGF gene polymorphisms on the risk of gastric pre-malignant condition. Patients and Methods: The G1612A and C936T polymorphisms in the 3'-untranslated region (3'-UTR) of the VEGF gene were genotyped in 337 cancer-free individuals. The presence of intestinal metaplasia in the gastric antrum was assesed in all. Gastritis scores were also assessed according to the updated Sydney system. Results: The 1612 GA genotype held a significantly higher incidence of intestinal metaplasia in H. pylori-positive individuals more than 65 years of age (OR=4.05, 95% CI=1.08-15.15, p=0.038). The degree of intestinal metaplasia was also higher among individuals with 1612 GA in the same generation (GG vs. GA; 0.98±0.87 vs. 1.55±0.96, p=0.026). Conclusion: The G1612A but not the C936T polymorphism of the VEGF gene is associated with gastric pre-malignant condition in older individuals.",

author = "Tomomitsu Tahara and Omiyasu Arisawa and Tomoyuki Shibata and Masakatsu Nakamura and Hiromi Yamashita and Daisuke Yoshioka and Masaaki Okubo and Naoko Maruyama and Toshiaki Kamano and Yoshio Kamiya and Hiroshi Fujita and Mitsuo Nagasaka and Masami Iwata and Kazuya Takahama and Akoto Watanabe and Hiroshi Nakano and Ichiro Hirata",

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Tahara, T, Arisawa, O, Shibata, T , Nakamura, M, Yamashita, H, Yoshioka, D, Okubo, M, Maruyama, N, Kamano, T, Kamiya, Y, Fujita, H, Nagasaka, M, Iwata, M, Takahama, K, Watanabe, A, Nakano, H & Hirata, I 2009, 'Effect of polymorphisms in the 3′-untranslated region (3′-UTR) of VEGF gene on gastric pre-malignant condition', Anticancer research, vol. 29, no. 2, pp. 485-489.

TY - JOUR

T1 - Effect of polymorphisms in the 3′-untranslated region (3′-UTR) of VEGF gene on gastric pre-malignant condition

AU - Tahara, Tomomitsu

AU - Arisawa, Omiyasu

AU - Shibata, Tomoyuki

AU - Nakamura, Masakatsu

AU - Yamashita, Hiromi

AU - Yoshioka, Daisuke

AU - Okubo, Masaaki

AU - Maruyama, Naoko

AU - Kamano, Toshiaki

AU - Kamiya, Yoshio

AU - Fujita, Hiroshi

AU - Nagasaka, Mitsuo

AU - Iwata, Masami

AU - Takahama, Kazuya

AU - Watanabe, Akoto

AU - Nakano, Hiroshi

AU - Hirata, Ichiro

PY - 2009/2

Y1 - 2009/2

N2 - Background: A complex interaction of host genetic and environmental factors may be relevant in Helicocobacter pylori-related gastric carcinogenesis. We investigated the effect of VEGF gene polymorphisms on the risk of gastric pre-malignant condition. Patients and Methods: The G1612A and C936T polymorphisms in the 3'-untranslated region (3'-UTR) of the VEGF gene were genotyped in 337 cancer-free individuals. The presence of intestinal metaplasia in the gastric antrum was assesed in all. Gastritis scores were also assessed according to the updated Sydney system. Results: The 1612 GA genotype held a significantly higher incidence of intestinal metaplasia in H. pylori-positive individuals more than 65 years of age (OR=4.05, 95% CI=1.08-15.15, p=0.038). The degree of intestinal metaplasia was also higher among individuals with 1612 GA in the same generation (GG vs. GA; 0.98±0.87 vs. 1.55±0.96, p=0.026). Conclusion: The G1612A but not the C936T polymorphism of the VEGF gene is associated with gastric pre-malignant condition in older individuals.

AB - Background: A complex interaction of host genetic and environmental factors may be relevant in Helicocobacter pylori-related gastric carcinogenesis. We investigated the effect of VEGF gene polymorphisms on the risk of gastric pre-malignant condition. Patients and Methods: The G1612A and C936T polymorphisms in the 3'-untranslated region (3'-UTR) of the VEGF gene were genotyped in 337 cancer-free individuals. The presence of intestinal metaplasia in the gastric antrum was assesed in all. Gastritis scores were also assessed according to the updated Sydney system. Results: The 1612 GA genotype held a significantly higher incidence of intestinal metaplasia in H. pylori-positive individuals more than 65 years of age (OR=4.05, 95% CI=1.08-15.15, p=0.038). The degree of intestinal metaplasia was also higher among individuals with 1612 GA in the same generation (GG vs. GA; 0.98±0.87 vs. 1.55±0.96, p=0.026). Conclusion: The G1612A but not the C936T polymorphism of the VEGF gene is associated with gastric pre-malignant condition in older individuals.

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M3 - Article

C2 - 19331191

AN - SCOPUS:61449180447

SN - 0250-7005

VL - 29

SP - 485

EP - 489

JO - Anticancer research

JF - Anticancer research

IS - 2

ER -

Effect of polymorphisms in the 3′-untranslated region (3′-UTR) of VEGF gene on gastric pre-malignant condition

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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