Effect of polymorphisms in the 3′-untranslated region (3′-UTR) of VEGF gene on gastric pre-malignant condition

Background: A complex interaction of host genetic and environmental factors may be relevant in Helicocobacter pylori-related gastric carcinogenesis. We investigated the effect of VEGF gene polymorphisms on the risk of gastric pre-malignant condition. Patients and Methods: The G1612A and C936T polymorphisms in the 3'-untranslated region (3'-UTR) of the VEGF gene were genotyped in 337 cancer-free individuals. The presence of intestinal metaplasia in the gastric antrum was assesed in all. Gastritis scores were also assessed according to the updated Sydney system. Results: The 1612 GA genotype held a significantly higher incidence of intestinal metaplasia in H. pylori-positive individuals more than 65 years of age (OR=4.05, 95% CI=1.08-15.15, p=0.038). The degree of intestinal metaplasia was also higher among individuals with 1612 GA in the same generation (GG vs. GA; 0.98±0.87 vs. 1.55±0.96, p=0.026). Conclusion: The G1612A but not the C936T polymorphism of the VEGF gene is associated with gastric pre-malignant condition in older individuals.