Effect of Posttransplant Diabetes Mellitus on Graft Loss After Living-Donor Kidney Transplant at a Single Institution

Yuka Muramatsu Maekawa, Kengo Horie, Koji Iinuma, Manabu Takai, Kaori Ohzawa, Tomohiro Tsuchiya, Daiki Kato, Tomoki Taniguchi, Hiroki Ito, Seiji Hishida, Keita Nakane, Kosuke Mizutani, Takuya Koie, Taku Kato

Research output: Contribution to journalArticlepeer-review

Abstract

Background: This study aimed to evaluate predictive factors for graft loss in patients who received kidney transplantation (KT) from living kidney donors (LKDs) at a single institute in Japan. Methods: Our study focused on patients with end-stage renal disease who underwent KT from LKDs and were followed up for at least 1 year after surgery. The primary end point was graft survival (GS). GS after KT was analyzed using the Kaplan-Meier method. GS according to subgroup classification was analyzed using the log-rank test. A multivariate analysis was performed using a Cox proportional hazard model. Results: The median follow-up period was 105.5 months after KT. The 5- and 10-year GS rates were 97.8% and 96.0% in KT recipients (KTRs) without posttransplant diabetes mellitus (PTDM) and 89.9% and 63.2% in those with PTDM, respectively. The rate of graft loss was significantly higher in KTRs with PTDM than in those without PTDM (P < .001). Of the KTRs whose diabetes mellitus (DM) was cured after KT, those who underwent dialysis because of diabetic nephropathy had no graft loss. In the multivariate analysis, the serum creatinine level at 1 month after KT, PTDM, and human leukocyte antigen mismatches were significantly associated with graft loss after KT. Conclusions: In this study, the rate of graft loss in KTRs with PTDM was significantly higher than that of KTRs without PTDM. However, among KTRs whose DM was cured after KT, those who underwent dialysis because of diabetic nephropathy had no graft loss.

Original languageEnglish
Pages (from-to)162-168
Number of pages7
JournalTransplantation Proceedings
Volume52
Issue number1
DOIs
Publication statusPublished - 01-01-2020
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Surgery
  • Transplantation

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