Effect of pyridone carboxylic acid anti-microbials on the generation of reactive oxygen species in vitro

H. Akamatsu, Y. Niwa, H. Sasaki, Y. Matoba, Y. Asada, T. Horio

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)

Abstract

The effects of ofloxacin, ciprofloxacin and balofloxacin on the reactive oxygen species (ROS) levels generated by human neutrophils was examined in vitro; ROS generated in a cell-free, xanthine-xanthine oxidase system was also assessed. The species investigated were superoxide radical anion (O2-), hydrogen peroxide (H,O,) and hydroxyl radical (OH·). Both ofloxacin and ciprofloxacin markedly decreased the levels of O2-, H2O2 and OH· generated by human neutrophils. On the other hand, these drugs did not affect any of the ROS examined in the xanthine-xanthine oxidase system. Balofloxacin showed no significant effect on ROS generated by either system. The present study indicates that ofloxacin and ciprofloxacin may exert an anti-inflammatory action by reducing the potent ROS species excessively generated by neutrophils at the sites of inflammation.

Original languageEnglish
Pages (from-to)345-351
Number of pages7
JournalJournal of International Medical Research
Volume24
Issue number4
DOIs
Publication statusPublished - 01-01-1996
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Cell Biology
  • Biochemistry, medical

Fingerprint Dive into the research topics of 'Effect of pyridone carboxylic acid anti-microbials on the generation of reactive oxygen species in vitro'. Together they form a unique fingerprint.

Cite this