Effect of salmon calcitonin on the lethality of quinolinic acid, an excitatory amino acid

Y. Maeda, T. Nakamura, T. Hasegawa, H. Furukawa, T. Nabeshima

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1 Citation (Scopus)

Abstract

The effect of salmon calcitonin (SCT) on the lethality of quinolinic acid (QA), an endogenous excitatory amino acid, was investigated in relation to the excitatory amino acid receptor/ion channel complex. SCT increased the LD50 value of QA in a bell-shaped fashion, but the difference was not significant. The non competitive N-methyl-D-aspartate (NMDA) receptor antagonists MK-801 and phencyclidine (PCP) inhibited QA lethality dose- dependently. SCT potentiated the inhibitory effects of these antagonists. The competitive and glycine site antagonists 3-((±)-2-carboxypiperazin-4- yl)propyl-1-phosphonic acid (CPP) and 7-chlorokynurenic acid (7C1K), respectively, inhibited QA lethality in a dose-dependent fashion. SCT did not potentiate the effect of either drug. These results suggest that SCT inhibits NMDA receptors by interacting with Ca ion channel.

Original languageEnglish
Pages (from-to)191-199
Number of pages9
JournalResearch Communications in Chemical Pathology and Pharmacology
Volume77
Issue number2
Publication statusPublished - 10-09-1992
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Toxicology
  • Pharmacology
  • Pharmacology, Toxicology and Pharmaceutics(all)

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