Abstract
The effect of salmon calcitonin (SCT) on the lethality of quinolinic acid (QA), an endogenous excitatory amino acid, was investigated in relation to the excitatory amino acid receptor/ion channel complex. SCT increased the LD50 value of QA in a bell-shaped fashion, but the difference was not significant. The non competitive N-methyl-D-aspartate (NMDA) receptor antagonists MK-801 and phencyclidine (PCP) inhibited QA lethality dose- dependently. SCT potentiated the inhibitory effects of these antagonists. The competitive and glycine site antagonists 3-((±)-2-carboxypiperazin-4- yl)propyl-1-phosphonic acid (CPP) and 7-chlorokynurenic acid (7C1K), respectively, inhibited QA lethality in a dose-dependent fashion. SCT did not potentiate the effect of either drug. These results suggest that SCT inhibits NMDA receptors by interacting with Ca ion channel.
| Original language | English |
|---|---|
| Pages (from-to) | 191-199 |
| Number of pages | 9 |
| Journal | Research Communications in Chemical Pathology and Pharmacology |
| Volume | 77 |
| Issue number | 2 |
| Publication status | Published - 1992 |
| Externally published | Yes |
All Science Journal Classification (ASJC) codes
- General Pharmacology, Toxicology and Pharmaceutics
- Pathology and Forensic Medicine
- Toxicology
- Pharmacology