Effect of salmon calcitonin on the lethality of quinolinic acid, an excitatory amino acid

Y. Maeda, T. Nakamura, T. Hasegawa, H. Furukawa, Toshitaka Nabeshima

Research output: Contribution to journalArticle

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Abstract

The effect of salmon calcitonin (SCT) on the lethality of quinolinic acid (QA), an endogenous excitatory amino acid, was investigated in relation to the excitatory amino acid receptor/ion channel complex. SCT increased the LD50 value of QA in a bell-shaped fashion, but the difference was not significant. The non competitive N-methyl-D-aspartate (NMDA) receptor antagonists MK-801 and phencyclidine (PCP) inhibited QA lethality dose- dependently. SCT potentiated the inhibitory effects of these antagonists. The competitive and glycine site antagonists 3-((±)-2-carboxypiperazin-4- yl)propyl-1-phosphonic acid (CPP) and 7-chlorokynurenic acid (7C1K), respectively, inhibited QA lethality in a dose-dependent fashion. SCT did not potentiate the effect of either drug. These results suggest that SCT inhibits NMDA receptors by interacting with Ca ion channel.

Original languageEnglish
Pages (from-to)191-199
Number of pages9
JournalResearch Communications in Chemical Pathology and Pharmacology
Volume77
Issue number2
Publication statusPublished - 10-09-1992
Externally publishedYes

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salmon calcitonin
Quinolinic Acid
Excitatory Amino Acids
N-Methyl-D-Aspartate Receptors
Ion Channels
Phencyclidine
Dizocilpine Maleate
Lethal Dose 50
Glutamate Receptors
Glycine

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Toxicology
  • Pharmacology
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

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abstract = "The effect of salmon calcitonin (SCT) on the lethality of quinolinic acid (QA), an endogenous excitatory amino acid, was investigated in relation to the excitatory amino acid receptor/ion channel complex. SCT increased the LD50 value of QA in a bell-shaped fashion, but the difference was not significant. The non competitive N-methyl-D-aspartate (NMDA) receptor antagonists MK-801 and phencyclidine (PCP) inhibited QA lethality dose- dependently. SCT potentiated the inhibitory effects of these antagonists. The competitive and glycine site antagonists 3-((±)-2-carboxypiperazin-4- yl)propyl-1-phosphonic acid (CPP) and 7-chlorokynurenic acid (7C1K), respectively, inhibited QA lethality in a dose-dependent fashion. SCT did not potentiate the effect of either drug. These results suggest that SCT inhibits NMDA receptors by interacting with Ca ion channel.",
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Effect of salmon calcitonin on the lethality of quinolinic acid, an excitatory amino acid. / Maeda, Y.; Nakamura, T.; Hasegawa, T.; Furukawa, H.; Nabeshima, Toshitaka.

In: Research Communications in Chemical Pathology and Pharmacology, Vol. 77, No. 2, 10.09.1992, p. 191-199.

Research output: Contribution to journalArticle

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AU - Nakamura, T.

AU - Hasegawa, T.

AU - Furukawa, H.

AU - Nabeshima, Toshitaka

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