Abstract
The effect of tizanidine [5-chloro-4-(2-imidazolin-2-yl-amino)-2,1,3- benzothiadiazole] on core temperature in the mouse was investigated in comparison with that of clonidine. Tizanidine decreased core temperature in unanaesthetized, freely-moving normal mice. Clonidine produced hypothermia in normal mice. The α2-antagonist yohimbine produced an antagonism to tizanidine- and clonidine-induced hypothermia, while naloxone failed to antagonize the hypothermia. It is concluded that tizanidine and clonidine produce a similar hypothermic effect via an α2-adrenoceptor, but not an endogenous opioid system.
| Original language | English |
|---|---|
| Pages (from-to) | 225-235 |
| Number of pages | 11 |
| Journal | Research Communications in Chemical Pathology and Pharmacology |
| Volume | 52 |
| Issue number | 2 |
| Publication status | Published - 01-01-1986 |
| Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Pathology and Forensic Medicine
- Toxicology
- Pharmacology
- Pharmacology, Toxicology and Pharmaceutics(all)