Effect of tizanidine on body temperature in the mouse

T. Kameyama, Toshitaka Nabeshima, K. Matsuno

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The effect of tizanidine [5-chloro-4-(2-imidazolin-2-yl-amino)-2,1,3- benzothiadiazole] on core temperature in the mouse was investigated in comparison with that of clonidine. Tizanidine decreased core temperature in unanaesthetized, freely-moving normal mice. Clonidine produced hypothermia in normal mice. The α2-antagonist yohimbine produced an antagonism to tizanidine- and clonidine-induced hypothermia, while naloxone failed to antagonize the hypothermia. It is concluded that tizanidine and clonidine produce a similar hypothermic effect via an α2-adrenoceptor, but not an endogenous opioid system.

Original languageEnglish
Pages (from-to)225-235
Number of pages11
JournalResearch Communications in Chemical Pathology and Pharmacology
Volume52
Issue number2
Publication statusPublished - 01-01-1986
Externally publishedYes

Fingerprint

Body Temperature
Hypothermia
Clonidine
Temperature
Induced Hypothermia
Yohimbine
Naloxone
Adrenergic Receptors
Opioid Analgesics
tizanidine

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Toxicology
  • Pharmacology
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

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Effect of tizanidine on body temperature in the mouse. / Kameyama, T.; Nabeshima, Toshitaka; Matsuno, K.

In: Research Communications in Chemical Pathology and Pharmacology, Vol. 52, No. 2, 01.01.1986, p. 225-235.

Research output: Contribution to journalArticle

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AB - The effect of tizanidine [5-chloro-4-(2-imidazolin-2-yl-amino)-2,1,3- benzothiadiazole] on core temperature in the mouse was investigated in comparison with that of clonidine. Tizanidine decreased core temperature in unanaesthetized, freely-moving normal mice. Clonidine produced hypothermia in normal mice. The α2-antagonist yohimbine produced an antagonism to tizanidine- and clonidine-induced hypothermia, while naloxone failed to antagonize the hypothermia. It is concluded that tizanidine and clonidine produce a similar hypothermic effect via an α2-adrenoceptor, but not an endogenous opioid system.

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