Abstract
The effect of tizanidine [5-chloro-4-(2-imidazolin-2-yl-amino)-2,1,3- benzothiadiazole] on core temperature in the mouse was investigated in comparison with that of clonidine. Tizanidine decreased core temperature in unanaesthetized, freely-moving normal mice. Clonidine produced hypothermia in normal mice. The α2-antagonist yohimbine produced an antagonism to tizanidine- and clonidine-induced hypothermia, while naloxone failed to antagonize the hypothermia. It is concluded that tizanidine and clonidine produce a similar hypothermic effect via an α2-adrenoceptor, but not an endogenous opioid system.
| Original language | English |
|---|---|
| Pages (from-to) | 225-235 |
| Number of pages | 11 |
| Journal | Research Communications in Chemical Pathology and Pharmacology |
| Volume | 52 |
| Issue number | 2 |
| Publication status | Published - 01-01-1986 |
| Externally published | Yes |
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All Science Journal Classification (ASJC) codes
- Pathology and Forensic Medicine
- Toxicology
- Pharmacology
- Pharmacology, Toxicology and Pharmaceutics(all)
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Effect of tizanidine on body temperature in the mouse. / Kameyama, T.; Nabeshima, Toshitaka; Matsuno, K.
In: Research Communications in Chemical Pathology and Pharmacology, Vol. 52, No. 2, 01.01.1986, p. 225-235.Research output: Contribution to journal › Article
TY - JOUR
T1 - Effect of tizanidine on body temperature in the mouse
AU - Kameyama, T.
AU - Nabeshima, Toshitaka
AU - Matsuno, K.
PY - 1986/1/1
Y1 - 1986/1/1
N2 - The effect of tizanidine [5-chloro-4-(2-imidazolin-2-yl-amino)-2,1,3- benzothiadiazole] on core temperature in the mouse was investigated in comparison with that of clonidine. Tizanidine decreased core temperature in unanaesthetized, freely-moving normal mice. Clonidine produced hypothermia in normal mice. The α2-antagonist yohimbine produced an antagonism to tizanidine- and clonidine-induced hypothermia, while naloxone failed to antagonize the hypothermia. It is concluded that tizanidine and clonidine produce a similar hypothermic effect via an α2-adrenoceptor, but not an endogenous opioid system.
AB - The effect of tizanidine [5-chloro-4-(2-imidazolin-2-yl-amino)-2,1,3- benzothiadiazole] on core temperature in the mouse was investigated in comparison with that of clonidine. Tizanidine decreased core temperature in unanaesthetized, freely-moving normal mice. Clonidine produced hypothermia in normal mice. The α2-antagonist yohimbine produced an antagonism to tizanidine- and clonidine-induced hypothermia, while naloxone failed to antagonize the hypothermia. It is concluded that tizanidine and clonidine produce a similar hypothermic effect via an α2-adrenoceptor, but not an endogenous opioid system.
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UR - http://www.scopus.com/inward/citedby.url?scp=0022503858&partnerID=8YFLogxK
M3 - Article
VL - 52
SP - 225
EP - 235
JO - Research Communications in Chemical Pathology and Pharmacology
JF - Research Communications in Chemical Pathology and Pharmacology
SN - 0034-5164
IS - 2
ER -