TY - JOUR
T1 - Effect of transmucosal fluid movement on zinc and copper absorption from the rat small intestine
AU - Kuzuya, Takafumi
AU - Hasegawa, Takaaki
AU - Ogura, Yozo
AU - Nabeshima, Toshitaka
PY - 1998
Y1 - 1998
N2 - 1. The effects of transmucosal fluid movement on zinc and Copper absorption from rat small intestine were investigated using an in recirculating perfusion method. 2. Transmucosal fluid movement was obtained by using hypo-, iso- or hyperosmotic perfusate containing various concentrations of sodium chloride. Linear correlations were obtained between net fluid movement and absorption rate constants, which were calculated from the perfusion decline of zinc (n = 15; r = 0.77) and copper (n = 15; r = 0.75). 3. The changes in serum levels of these metals did not correlate with the increase in the absorption rate. 4. The present study indicates that zinc and copper absorption is dependent on transmucosal fluid movement.
AB - 1. The effects of transmucosal fluid movement on zinc and Copper absorption from rat small intestine were investigated using an in recirculating perfusion method. 2. Transmucosal fluid movement was obtained by using hypo-, iso- or hyperosmotic perfusate containing various concentrations of sodium chloride. Linear correlations were obtained between net fluid movement and absorption rate constants, which were calculated from the perfusion decline of zinc (n = 15; r = 0.77) and copper (n = 15; r = 0.75). 3. The changes in serum levels of these metals did not correlate with the increase in the absorption rate. 4. The present study indicates that zinc and copper absorption is dependent on transmucosal fluid movement.
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U2 - 10.1111/j.1440-1681.1998.tb02224.x
DO - 10.1111/j.1440-1681.1998.tb02224.x
M3 - Article
C2 - 9673815
AN - SCOPUS:0031806544
SN - 0305-1870
VL - 25
SP - 412
EP - 416
JO - Clinical and Experimental Pharmacology and Physiology
JF - Clinical and Experimental Pharmacology and Physiology
IS - 6
ER -