Effect of transmucosal fluid movement on zinc and copper absorption from the rat small intestine

Takafumi Kuzuya, Takaaki Hasegawa, Yozo Ogura, Toshitaka Nabeshima

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Abstract

1. The effects of transmucosal fluid movement on zinc and Copper absorption from rat small intestine were investigated using an in recirculating perfusion method. 2. Transmucosal fluid movement was obtained by using hypo-, iso- or hyperosmotic perfusate containing various concentrations of sodium chloride. Linear correlations were obtained between net fluid movement and absorption rate constants, which were calculated from the perfusion decline of zinc (n = 15; r = 0.77) and copper (n = 15; r = 0.75). 3. The changes in serum levels of these metals did not correlate with the increase in the absorption rate. 4. The present study indicates that zinc and copper absorption is dependent on transmucosal fluid movement.

Original languageEnglish
Pages (from-to)412-416
Number of pages5
JournalClinical and Experimental Pharmacology and Physiology
Volume25
Issue number6
DOIs
Publication statusPublished - 01-01-1998
Externally publishedYes

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All Science Journal Classification (ASJC) codes

  • Physiology
  • Pharmacology
  • Physiology (medical)

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