Effectiveness and safety of systemic cyclosporine for high-risk keratoplasty

Masahiro Omoto, Shigeto Shimmura, Murat Dogru, Jun Shimazaki, Kazuo Tsubota

Research output: Contribution to journalArticlepeer-review


We reviewed 51 high-risk eyes of 50 patients receiving penetrating keratoplasty. They were given systemic cyclosporine A to prevent immune graft rejection. High risk was defined as the presence of corneal neovascularization in 2 or more quadrants or repeat keratoplasty. During follow-up for an average of 14.9 ± 10.2 months, the graft remained transparent in 37 eyes (73%). Allograft rejection developed in 13 eyes (26%). As temporary side effects, hiccups, abdominal pain, systemic hypertension, mental confusion, and dysuria developed in one patient each. The findings show that systemic cyclosporine A is safe and effective in preventing immune graft rejection if protocol is strictly adhered to.

Original languageEnglish
Pages (from-to)773-776
Number of pages4
JournalJapanese Journal of Clinical Ophthalmology
Issue number5
Publication statusPublished - 2004
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Ophthalmology


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