Effectiveness of exercise-induced cytokines in alleviating arthritis symptoms in arthritis model mice

Takumi Kito, Toshio Teranishi, Kazuhiro Nishii, Kazuyoshi Sakai, Mamoru Matsubara, Koji Yamada

Research output: Contribution to journalArticle

Abstract

Recently, health awareness in Japan has been increasing and active exercise is now recommended to prevent lifestyle-related diseases. Cytokine activities have many positive effects in maintaining the health of a number of organs in the body. Myokines are cytokines secreted by skeletal muscles in response to exercise stimulation, and have recently generated much attention. Around 700,000 patients in Japan suffer from rheumatoid arthritis, making it the most prevalent autoimmune disease that requires active prevention and treatment. In the present study, a mouse model of spontaneous arthritis (SKG/Jcl) was subjected to continuous exercise stimulation, starting before the disease onset, to examine the effects of anti-inflammatory and inflammatory cytokine secretion on arthritis. For this stimulation, we developed a device that combines shaking and vibration. The results revealed that exercise stimulation delayed the onset of arthritis and slowed its progression. Thickened articular cartilage and multiple aggregates of chondrocytes were also observed. Further, exercise stimulation increased the expression of IL-6, IL-10, and IL-15, and inhibited TNF-α expression. From these results, we infer that the anti-inflammatory effects of IL-6 and IL-10, which showed increased expression upon exercise stimulation, inhibited the inflammatory activity of TNF-α and possibly delayed the onset of arthritis and slowed its progression. Novel methods for preventing and treating arthritis under clinical settings can be developed on the basis of these findings.

Original languageEnglish
Pages (from-to)81-88
Number of pages8
JournalOkajimas Folia Anatomica Japonica
Volume93
Issue number3
DOIs
Publication statusPublished - 01-11-2016

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Arthritis
Exercise
Cytokines
Interleukin-10
Interleukin-6
Japan
Anti-Inflammatory Agents
Interleukin-15
Health
Articular Cartilage
Chondrocytes
Vibration
Autoimmune Diseases
Life Style
Rheumatoid Arthritis
Skeletal Muscle
Equipment and Supplies

All Science Journal Classification (ASJC) codes

  • Anatomy

Cite this

Kito, Takumi ; Teranishi, Toshio ; Nishii, Kazuhiro ; Sakai, Kazuyoshi ; Matsubara, Mamoru ; Yamada, Koji. / Effectiveness of exercise-induced cytokines in alleviating arthritis symptoms in arthritis model mice. In: Okajimas Folia Anatomica Japonica. 2016 ; Vol. 93, No. 3. pp. 81-88.
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Effectiveness of exercise-induced cytokines in alleviating arthritis symptoms in arthritis model mice. / Kito, Takumi; Teranishi, Toshio; Nishii, Kazuhiro; Sakai, Kazuyoshi; Matsubara, Mamoru; Yamada, Koji.

In: Okajimas Folia Anatomica Japonica, Vol. 93, No. 3, 01.11.2016, p. 81-88.

Research output: Contribution to journalArticle

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