Effectiveness of Preceding Solo Kidney Transplantation for Type 1 Diabetes With End-Stage Renal Failure

Taihei Ito, Takashi Kenmochi, N. Aida, K. Kurihara, A. Kawai

Research output: Contribution to journalArticle

Abstract

Preceding solo kidney transplantation for type 1 diabetes with end-stage renal failure is controversial because of less pancreatic graft survival in pancreas transplantation after kidney transplantation (PAK) than in simultaneous pancreas and kidney transplantation (SPK). Methods: To study the effectiveness of preceding solo kidney transplantation for type 1 diabetes with end-stage renal failure, comparative retrospective analysis was performed between SPK (n = 232) and PAK (n = 39) that were performed until December 2016. Results: At 1, 3, and 5 years, pancreatic graft survival in SPK was 87.5%, 86.4%, and 82.8%, respectively, and 87.1%, 65.0%, and 49.1%, respectively, in PAK, which showed lesser long-term graft survival than SPK. Because 10 cases out of 16 (62.5%) failed into pancreatic graft loss with rejection in PAK, which was about 3 times more than in SPK, control of rejection is very important; rejection episodes were decreased by rabbit antithymocyte globulin induction resulting in improved graft survival. Five-year patient survival was 88.0% in SPK and 96.6% in PAK. Conclusion: Considering patient survival, preceding solo kidney transplantation for type 1 diabetes with end-stage renal failure should be performed if a donor is available.

Original languageEnglish
Pages (from-to)3249-3254
Number of pages6
JournalTransplantation Proceedings
Volume50
Issue number10
DOIs
Publication statusPublished - 01-12-2018

Fingerprint

Type 1 Diabetes Mellitus
Kidney Transplantation
Chronic Kidney Failure
Pancreas Transplantation
Graft Survival
Antilymphocyte Serum
Survival
Graft Rejection
Tissue Donors
Rabbits
Transplants

All Science Journal Classification (ASJC) codes

  • Surgery
  • Transplantation

Cite this

@article{3c5d5ff11fa94439b651f0e6f484914e,
title = "Effectiveness of Preceding Solo Kidney Transplantation for Type 1 Diabetes With End-Stage Renal Failure",
abstract = "Preceding solo kidney transplantation for type 1 diabetes with end-stage renal failure is controversial because of less pancreatic graft survival in pancreas transplantation after kidney transplantation (PAK) than in simultaneous pancreas and kidney transplantation (SPK). Methods: To study the effectiveness of preceding solo kidney transplantation for type 1 diabetes with end-stage renal failure, comparative retrospective analysis was performed between SPK (n = 232) and PAK (n = 39) that were performed until December 2016. Results: At 1, 3, and 5 years, pancreatic graft survival in SPK was 87.5{\%}, 86.4{\%}, and 82.8{\%}, respectively, and 87.1{\%}, 65.0{\%}, and 49.1{\%}, respectively, in PAK, which showed lesser long-term graft survival than SPK. Because 10 cases out of 16 (62.5{\%}) failed into pancreatic graft loss with rejection in PAK, which was about 3 times more than in SPK, control of rejection is very important; rejection episodes were decreased by rabbit antithymocyte globulin induction resulting in improved graft survival. Five-year patient survival was 88.0{\%} in SPK and 96.6{\%} in PAK. Conclusion: Considering patient survival, preceding solo kidney transplantation for type 1 diabetes with end-stage renal failure should be performed if a donor is available.",
author = "Taihei Ito and Takashi Kenmochi and N. Aida and K. Kurihara and A. Kawai",
year = "2018",
month = "12",
day = "1",
doi = "10.1016/j.transproceed.2018.06.014",
language = "English",
volume = "50",
pages = "3249--3254",
journal = "Transplantation Proceedings",
issn = "0041-1345",
publisher = "Elsevier USA",
number = "10",

}

Effectiveness of Preceding Solo Kidney Transplantation for Type 1 Diabetes With End-Stage Renal Failure. / Ito, Taihei; Kenmochi, Takashi; Aida, N.; Kurihara, K.; Kawai, A.

In: Transplantation Proceedings, Vol. 50, No. 10, 01.12.2018, p. 3249-3254.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Effectiveness of Preceding Solo Kidney Transplantation for Type 1 Diabetes With End-Stage Renal Failure

AU - Ito, Taihei

AU - Kenmochi, Takashi

AU - Aida, N.

AU - Kurihara, K.

AU - Kawai, A.

PY - 2018/12/1

Y1 - 2018/12/1

N2 - Preceding solo kidney transplantation for type 1 diabetes with end-stage renal failure is controversial because of less pancreatic graft survival in pancreas transplantation after kidney transplantation (PAK) than in simultaneous pancreas and kidney transplantation (SPK). Methods: To study the effectiveness of preceding solo kidney transplantation for type 1 diabetes with end-stage renal failure, comparative retrospective analysis was performed between SPK (n = 232) and PAK (n = 39) that were performed until December 2016. Results: At 1, 3, and 5 years, pancreatic graft survival in SPK was 87.5%, 86.4%, and 82.8%, respectively, and 87.1%, 65.0%, and 49.1%, respectively, in PAK, which showed lesser long-term graft survival than SPK. Because 10 cases out of 16 (62.5%) failed into pancreatic graft loss with rejection in PAK, which was about 3 times more than in SPK, control of rejection is very important; rejection episodes were decreased by rabbit antithymocyte globulin induction resulting in improved graft survival. Five-year patient survival was 88.0% in SPK and 96.6% in PAK. Conclusion: Considering patient survival, preceding solo kidney transplantation for type 1 diabetes with end-stage renal failure should be performed if a donor is available.

AB - Preceding solo kidney transplantation for type 1 diabetes with end-stage renal failure is controversial because of less pancreatic graft survival in pancreas transplantation after kidney transplantation (PAK) than in simultaneous pancreas and kidney transplantation (SPK). Methods: To study the effectiveness of preceding solo kidney transplantation for type 1 diabetes with end-stage renal failure, comparative retrospective analysis was performed between SPK (n = 232) and PAK (n = 39) that were performed until December 2016. Results: At 1, 3, and 5 years, pancreatic graft survival in SPK was 87.5%, 86.4%, and 82.8%, respectively, and 87.1%, 65.0%, and 49.1%, respectively, in PAK, which showed lesser long-term graft survival than SPK. Because 10 cases out of 16 (62.5%) failed into pancreatic graft loss with rejection in PAK, which was about 3 times more than in SPK, control of rejection is very important; rejection episodes were decreased by rabbit antithymocyte globulin induction resulting in improved graft survival. Five-year patient survival was 88.0% in SPK and 96.6% in PAK. Conclusion: Considering patient survival, preceding solo kidney transplantation for type 1 diabetes with end-stage renal failure should be performed if a donor is available.

UR - http://www.scopus.com/inward/record.url?scp=85058557685&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85058557685&partnerID=8YFLogxK

U2 - 10.1016/j.transproceed.2018.06.014

DO - 10.1016/j.transproceed.2018.06.014

M3 - Article

C2 - 30577193

AN - SCOPUS:85058557685

VL - 50

SP - 3249

EP - 3254

JO - Transplantation Proceedings

JF - Transplantation Proceedings

SN - 0041-1345

IS - 10

ER -