Abstract
The effect of l,3-diphenyl-5-(2-dimethylaminopropionamide)-pyrazole[difenamizole], an analgesic synthesized by the present authors, on the performance of a conditioned avoidance was compared with that of analgesic doses of morphine, aminopyrine, chlorpromazine and chlordiazepoxide in rats. Experiments were conducted in a two-compartment rat shuttle-box system using 20-trial sessions and a 5-sec conditioned stimulus-unconditioned stimulus interval. Difenamizole (100-400 mg/kg, p.o.) increased significantly the number of avoidance failures, decreased the number of fecal boluses excreted, and prolonged response latency times. Aminopyrine (100-400 mg/kg, p.o.) produced a dose-related prolongation in response latency time, but the effect of this drug on the percentage avoidance was less than that produced by difenamizole at low doses. The avoidance behaviour was hardly influenced by analgesic doses of morphine (10-40 mg/kg, p.o.) and chlordiazepoxide (10-40 mg/kg, P.O.). Chlorpromazine (5-20 mg/kg, p.o.) produced a dose-related depression in percentage avoidance and a doserelated prolongation in response latency time. The effect of difenamizole on conditioned avoidance performance was similar to that produced by chlorpromazine.
| Original language | English |
|---|---|
| Pages (from-to) | 249-256 |
| Number of pages | 8 |
| Journal | Neuropharmacology |
| Volume | 17 |
| Issue number | 4-5 |
| DOIs | |
| Publication status | Published - 01-01-1978 |
| Externally published | Yes |
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All Science Journal Classification (ASJC) codes
- Pharmacology
- Cellular and Molecular Neuroscience
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Effects of 1,3-diphenyl-5-(2-dimethylaminopropionamide)-pyrazole[difenamizole] on a conditioned avoidance response. / Tsutomu, Kameyama; Nabeshima, Toshitaka.
In: Neuropharmacology, Vol. 17, No. 4-5, 01.01.1978, p. 249-256.Research output: Contribution to journal › Article
TY - JOUR
T1 - Effects of 1,3-diphenyl-5-(2-dimethylaminopropionamide)-pyrazole[difenamizole] on a conditioned avoidance response
AU - Tsutomu, Kameyama
AU - Nabeshima, Toshitaka
PY - 1978/1/1
Y1 - 1978/1/1
N2 - The effect of l,3-diphenyl-5-(2-dimethylaminopropionamide)-pyrazole[difenamizole], an analgesic synthesized by the present authors, on the performance of a conditioned avoidance was compared with that of analgesic doses of morphine, aminopyrine, chlorpromazine and chlordiazepoxide in rats. Experiments were conducted in a two-compartment rat shuttle-box system using 20-trial sessions and a 5-sec conditioned stimulus-unconditioned stimulus interval. Difenamizole (100-400 mg/kg, p.o.) increased significantly the number of avoidance failures, decreased the number of fecal boluses excreted, and prolonged response latency times. Aminopyrine (100-400 mg/kg, p.o.) produced a dose-related prolongation in response latency time, but the effect of this drug on the percentage avoidance was less than that produced by difenamizole at low doses. The avoidance behaviour was hardly influenced by analgesic doses of morphine (10-40 mg/kg, p.o.) and chlordiazepoxide (10-40 mg/kg, P.O.). Chlorpromazine (5-20 mg/kg, p.o.) produced a dose-related depression in percentage avoidance and a doserelated prolongation in response latency time. The effect of difenamizole on conditioned avoidance performance was similar to that produced by chlorpromazine.
AB - The effect of l,3-diphenyl-5-(2-dimethylaminopropionamide)-pyrazole[difenamizole], an analgesic synthesized by the present authors, on the performance of a conditioned avoidance was compared with that of analgesic doses of morphine, aminopyrine, chlorpromazine and chlordiazepoxide in rats. Experiments were conducted in a two-compartment rat shuttle-box system using 20-trial sessions and a 5-sec conditioned stimulus-unconditioned stimulus interval. Difenamizole (100-400 mg/kg, p.o.) increased significantly the number of avoidance failures, decreased the number of fecal boluses excreted, and prolonged response latency times. Aminopyrine (100-400 mg/kg, p.o.) produced a dose-related prolongation in response latency time, but the effect of this drug on the percentage avoidance was less than that produced by difenamizole at low doses. The avoidance behaviour was hardly influenced by analgesic doses of morphine (10-40 mg/kg, p.o.) and chlordiazepoxide (10-40 mg/kg, P.O.). Chlorpromazine (5-20 mg/kg, p.o.) produced a dose-related depression in percentage avoidance and a doserelated prolongation in response latency time. The effect of difenamizole on conditioned avoidance performance was similar to that produced by chlorpromazine.
UR - http://www.scopus.com/inward/record.url?scp=0018187658&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0018187658&partnerID=8YFLogxK
U2 - 10.1016/0028-3908(78)90108-9
DO - 10.1016/0028-3908(78)90108-9
M3 - Article
C2 - 652137
AN - SCOPUS:0018187658
VL - 17
SP - 249
EP - 256
JO - Neuropharmacology
JF - Neuropharmacology
SN - 0028-3908
IS - 4-5
ER -