Abstract
Effects of 5-HT agonists on learning and memory were examined using a step-down passive avoidance task in mice. A nonselective 5-HT agonist. 5- methoxy-N,N-dimethyltryptamine (5-MeODMT) given immediately after training remarkably decreased the step-down latencies in the retention test. A 5-HT1 antagonist, (±)-pindolol significantly attenuated 5-MeODMT-induced amnesia. 5-HT(1A) selective agonists. 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH- DPAT) and 1-[2-(4-aminophenyl)ethyl]-4-(3-trifluoromethylphenyl) piperazine (PAPP) given immediately after training caused impairment of memory. 8-OH- DPAT-induced memory impairment was inhibited by a nonselective 5-HT antagonist, methysergide and a 5-HT1 antagonist, (±)-pindolol, whereas a selective 5-HT2 antagonist, ritanserin was inactive. These results suggest that 5-HT(1A) receptors may be linked to memory process in mice.
| Original language | English |
|---|---|
| Pages (from-to) | 87-108 |
| Number of pages | 22 |
| Journal | Research Communications in Psychology, Psychiatry and Behavior |
| Volume | 17 |
| Issue number | 3-4 |
| Publication status | Published - 01-12-1992 |
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All Science Journal Classification (ASJC) codes
- Psychiatry and Mental health
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Effects of 5-HT(1A) receptor agonists on the passive avoidance task in mice. / Nabeshima, Toshitaka; Itoh, K.; Kawashima, K.; Kameyama, T.; Shih, J. C.
In: Research Communications in Psychology, Psychiatry and Behavior, Vol. 17, No. 3-4, 01.12.1992, p. 87-108.Research output: Contribution to journal › Article
TY - JOUR
T1 - Effects of 5-HT(1A) receptor agonists on the passive avoidance task in mice
AU - Nabeshima, Toshitaka
AU - Itoh, K.
AU - Kawashima, K.
AU - Kameyama, T.
AU - Shih, J. C.
PY - 1992/12/1
Y1 - 1992/12/1
N2 - Effects of 5-HT agonists on learning and memory were examined using a step-down passive avoidance task in mice. A nonselective 5-HT agonist. 5- methoxy-N,N-dimethyltryptamine (5-MeODMT) given immediately after training remarkably decreased the step-down latencies in the retention test. A 5-HT1 antagonist, (±)-pindolol significantly attenuated 5-MeODMT-induced amnesia. 5-HT(1A) selective agonists. 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH- DPAT) and 1-[2-(4-aminophenyl)ethyl]-4-(3-trifluoromethylphenyl) piperazine (PAPP) given immediately after training caused impairment of memory. 8-OH- DPAT-induced memory impairment was inhibited by a nonselective 5-HT antagonist, methysergide and a 5-HT1 antagonist, (±)-pindolol, whereas a selective 5-HT2 antagonist, ritanserin was inactive. These results suggest that 5-HT(1A) receptors may be linked to memory process in mice.
AB - Effects of 5-HT agonists on learning and memory were examined using a step-down passive avoidance task in mice. A nonselective 5-HT agonist. 5- methoxy-N,N-dimethyltryptamine (5-MeODMT) given immediately after training remarkably decreased the step-down latencies in the retention test. A 5-HT1 antagonist, (±)-pindolol significantly attenuated 5-MeODMT-induced amnesia. 5-HT(1A) selective agonists. 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH- DPAT) and 1-[2-(4-aminophenyl)ethyl]-4-(3-trifluoromethylphenyl) piperazine (PAPP) given immediately after training caused impairment of memory. 8-OH- DPAT-induced memory impairment was inhibited by a nonselective 5-HT antagonist, methysergide and a 5-HT1 antagonist, (±)-pindolol, whereas a selective 5-HT2 antagonist, ritanserin was inactive. These results suggest that 5-HT(1A) receptors may be linked to memory process in mice.
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UR - http://www.scopus.com/inward/citedby.url?scp=0027006692&partnerID=8YFLogxK
M3 - Article
VL - 17
SP - 87
EP - 108
JO - Research Communications in Psychology, Psychiatry and Behavior
JF - Research Communications in Psychology, Psychiatry and Behavior
SN - 0362-2428
IS - 3-4
ER -