Effects of 5-HT(1A) receptor agonists on the passive avoidance task in mice

T. Nabeshima; K. Itoh; K. Kawashima; T. Kameyama; J. C. Shih

Effects of 5-HT(1A) receptor agonists on the passive avoidance task in mice

T. Nabeshima, K. Itoh, K. Kawashima, T. Kameyama, J. C. Shih

Research output: Contribution to journal › Article

Abstract

Effects of 5-HT agonists on learning and memory were examined using a step-down passive avoidance task in mice. A nonselective 5-HT agonist. 5- methoxy-N,N-dimethyltryptamine (5-MeODMT) given immediately after training remarkably decreased the step-down latencies in the retention test. A 5-HT₁ antagonist, (±)-pindolol significantly attenuated 5-MeODMT-induced amnesia. 5-HT(1A) selective agonists. 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH- DPAT) and 1-[2-(4-aminophenyl)ethyl]-4-(3-trifluoromethylphenyl) piperazine (PAPP) given immediately after training caused impairment of memory. 8-OH- DPAT-induced memory impairment was inhibited by a nonselective 5-HT antagonist, methysergide and a 5-HT₁ antagonist, (±)-pindolol, whereas a selective 5-HT₂ antagonist, ritanserin was inactive. These results suggest that 5-HT(1A) receptors may be linked to memory process in mice.

Original language	English
Pages (from-to)	87-108
Number of pages	22
Journal	Research Communications in Psychology, Psychiatry and Behavior
Volume	17
Issue number	3-4
Publication status	Published - 01-12-1992
Externally published	Yes

All Science Journal Classification (ASJC) codes

Psychiatry and Mental health

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Nabeshima, T., Itoh, K., Kawashima, K., Kameyama, T., & Shih, J. C. (1992). Effects of 5-HT(1A) receptor agonists on the passive avoidance task in mice. Research Communications in Psychology, Psychiatry and Behavior, 17(3-4), 87-108.

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abstract = "Effects of 5-HT agonists on learning and memory were examined using a step-down passive avoidance task in mice. A nonselective 5-HT agonist. 5- methoxy-N,N-dimethyltryptamine (5-MeODMT) given immediately after training remarkably decreased the step-down latencies in the retention test. A 5-HT1 antagonist, (±)-pindolol significantly attenuated 5-MeODMT-induced amnesia. 5-HT(1A) selective agonists. 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH- DPAT) and 1-[2-(4-aminophenyl)ethyl]-4-(3-trifluoromethylphenyl) piperazine (PAPP) given immediately after training caused impairment of memory. 8-OH- DPAT-induced memory impairment was inhibited by a nonselective 5-HT antagonist, methysergide and a 5-HT1 antagonist, (±)-pindolol, whereas a selective 5-HT2 antagonist, ritanserin was inactive. These results suggest that 5-HT(1A) receptors may be linked to memory process in mice.",

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AU - Shih, J. C.

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N2 - Effects of 5-HT agonists on learning and memory were examined using a step-down passive avoidance task in mice. A nonselective 5-HT agonist. 5- methoxy-N,N-dimethyltryptamine (5-MeODMT) given immediately after training remarkably decreased the step-down latencies in the retention test. A 5-HT1 antagonist, (±)-pindolol significantly attenuated 5-MeODMT-induced amnesia. 5-HT(1A) selective agonists. 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH- DPAT) and 1-[2-(4-aminophenyl)ethyl]-4-(3-trifluoromethylphenyl) piperazine (PAPP) given immediately after training caused impairment of memory. 8-OH- DPAT-induced memory impairment was inhibited by a nonselective 5-HT antagonist, methysergide and a 5-HT1 antagonist, (±)-pindolol, whereas a selective 5-HT2 antagonist, ritanserin was inactive. These results suggest that 5-HT(1A) receptors may be linked to memory process in mice.

AB - Effects of 5-HT agonists on learning and memory were examined using a step-down passive avoidance task in mice. A nonselective 5-HT agonist. 5- methoxy-N,N-dimethyltryptamine (5-MeODMT) given immediately after training remarkably decreased the step-down latencies in the retention test. A 5-HT1 antagonist, (±)-pindolol significantly attenuated 5-MeODMT-induced amnesia. 5-HT(1A) selective agonists. 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH- DPAT) and 1-[2-(4-aminophenyl)ethyl]-4-(3-trifluoromethylphenyl) piperazine (PAPP) given immediately after training caused impairment of memory. 8-OH- DPAT-induced memory impairment was inhibited by a nonselective 5-HT antagonist, methysergide and a 5-HT1 antagonist, (±)-pindolol, whereas a selective 5-HT2 antagonist, ritanserin was inactive. These results suggest that 5-HT(1A) receptors may be linked to memory process in mice.

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