Abstract
A role played by serotonergic neuronal system in cycloheximide (CXM)-induced amnesia was studied in mice using a step-down passive avoidance task. CXM (30 mg/kg SC) given immediately after training caused impairment of memory. Nonselective serotonin (5-HT) antagonist methysergide and selective 5-HT2 antagonist ritanserin significantly attenuated impairment of memory caused by CXM. 5-HT1 antagonist (±)-pindolol had no effect on CXM-induced amnesia. The antiamnesic effect of ritanserin on CXM-induced amnesia was antagonized by 5-HT (ICV), but not by nonselective 5-HT agonist 5-methoxy-N,N-dimethyltryptamine and 5-HT1A selective agonist 8-hydroxy-2-(di-n-propylamino)tetralin at the dose level which did not cause the memory disruption. Scopolamine antagonized the antiamnesic effects of methysergide and ritanserin on CXM-induced amnesia. These results suggest that 5-HT2 receptors and cholinergic neuronal system may play an important role in memory formation.
| Original language | English |
|---|---|
| Pages (from-to) | 787-790 |
| Number of pages | 4 |
| Journal | Pharmacology, Biochemistry and Behavior |
| Volume | 32 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 03-1989 |
Fingerprint
All Science Journal Classification (ASJC) codes
- Biochemistry
- Toxicology
- Pharmacology
- Clinical Biochemistry
- Biological Psychiatry
- Behavioral Neuroscience
Cite this
}
Effects of 5-HT2 receptor antagonist on cycloheximide-induced amnesia in mice. / Nabeshima, Toshitaka; Itoh, Kaname; Kawashima, Kazuaki; Kameyama, Tsutomu.
In: Pharmacology, Biochemistry and Behavior, Vol. 32, No. 3, 03.1989, p. 787-790.Research output: Contribution to journal › Article
TY - JOUR
T1 - Effects of 5-HT2 receptor antagonist on cycloheximide-induced amnesia in mice
AU - Nabeshima, Toshitaka
AU - Itoh, Kaname
AU - Kawashima, Kazuaki
AU - Kameyama, Tsutomu
PY - 1989/3
Y1 - 1989/3
N2 - A role played by serotonergic neuronal system in cycloheximide (CXM)-induced amnesia was studied in mice using a step-down passive avoidance task. CXM (30 mg/kg SC) given immediately after training caused impairment of memory. Nonselective serotonin (5-HT) antagonist methysergide and selective 5-HT2 antagonist ritanserin significantly attenuated impairment of memory caused by CXM. 5-HT1 antagonist (±)-pindolol had no effect on CXM-induced amnesia. The antiamnesic effect of ritanserin on CXM-induced amnesia was antagonized by 5-HT (ICV), but not by nonselective 5-HT agonist 5-methoxy-N,N-dimethyltryptamine and 5-HT1A selective agonist 8-hydroxy-2-(di-n-propylamino)tetralin at the dose level which did not cause the memory disruption. Scopolamine antagonized the antiamnesic effects of methysergide and ritanserin on CXM-induced amnesia. These results suggest that 5-HT2 receptors and cholinergic neuronal system may play an important role in memory formation.
AB - A role played by serotonergic neuronal system in cycloheximide (CXM)-induced amnesia was studied in mice using a step-down passive avoidance task. CXM (30 mg/kg SC) given immediately after training caused impairment of memory. Nonselective serotonin (5-HT) antagonist methysergide and selective 5-HT2 antagonist ritanserin significantly attenuated impairment of memory caused by CXM. 5-HT1 antagonist (±)-pindolol had no effect on CXM-induced amnesia. The antiamnesic effect of ritanserin on CXM-induced amnesia was antagonized by 5-HT (ICV), but not by nonselective 5-HT agonist 5-methoxy-N,N-dimethyltryptamine and 5-HT1A selective agonist 8-hydroxy-2-(di-n-propylamino)tetralin at the dose level which did not cause the memory disruption. Scopolamine antagonized the antiamnesic effects of methysergide and ritanserin on CXM-induced amnesia. These results suggest that 5-HT2 receptors and cholinergic neuronal system may play an important role in memory formation.
UR - http://www.scopus.com/inward/record.url?scp=0024475256&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0024475256&partnerID=8YFLogxK
U2 - 10.1016/0091-3057(89)90034-8
DO - 10.1016/0091-3057(89)90034-8
M3 - Article
C2 - 2500672
AN - SCOPUS:0024475256
VL - 32
SP - 787
EP - 790
JO - Pharmacology Biochemistry and Behavior
JF - Pharmacology Biochemistry and Behavior
SN - 0091-3057
IS - 3
ER -