Effects of 5-HT2 receptor antagonist on cycloheximide-induced amnesia in mice

Toshitaka Nabeshima, Kaname Itoh, Kazuaki Kawashima, Tsutomu Kameyama

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

A role played by serotonergic neuronal system in cycloheximide (CXM)-induced amnesia was studied in mice using a step-down passive avoidance task. CXM (30 mg/kg SC) given immediately after training caused impairment of memory. Nonselective serotonin (5-HT) antagonist methysergide and selective 5-HT2 antagonist ritanserin significantly attenuated impairment of memory caused by CXM. 5-HT1 antagonist (±)-pindolol had no effect on CXM-induced amnesia. The antiamnesic effect of ritanserin on CXM-induced amnesia was antagonized by 5-HT (ICV), but not by nonselective 5-HT agonist 5-methoxy-N,N-dimethyltryptamine and 5-HT1A selective agonist 8-hydroxy-2-(di-n-propylamino)tetralin at the dose level which did not cause the memory disruption. Scopolamine antagonized the antiamnesic effects of methysergide and ritanserin on CXM-induced amnesia. These results suggest that 5-HT2 receptors and cholinergic neuronal system may play an important role in memory formation.

Original languageEnglish
Pages (from-to)787-790
Number of pages4
JournalPharmacology, Biochemistry and Behavior
Volume32
Issue number3
DOIs
Publication statusPublished - 01-01-1989

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Serotonin 5-HT2 Receptor Antagonists
Amnesia
Cycloheximide
Ritanserin
Data storage equipment
Methysergide
Serotonin
Methoxydimethyltryptamines
Serotonin 5-HT1 Receptor Antagonists
Serotonin 5-HT1 Receptor Agonists
Pindolol
8-Hydroxy-2-(di-n-propylamino)tetralin
Serotonin Receptor Agonists
Serotonin Antagonists
Scopolamine Hydrobromide
Cholinergic Receptors

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience

Cite this

Nabeshima, Toshitaka ; Itoh, Kaname ; Kawashima, Kazuaki ; Kameyama, Tsutomu. / Effects of 5-HT2 receptor antagonist on cycloheximide-induced amnesia in mice. In: Pharmacology, Biochemistry and Behavior. 1989 ; Vol. 32, No. 3. pp. 787-790.
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Effects of 5-HT2 receptor antagonist on cycloheximide-induced amnesia in mice. / Nabeshima, Toshitaka; Itoh, Kaname; Kawashima, Kazuaki; Kameyama, Tsutomu.

In: Pharmacology, Biochemistry and Behavior, Vol. 32, No. 3, 01.01.1989, p. 787-790.

Research output: Contribution to journalArticle

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