Effects of 5-HT2 receptor antagonist on cycloheximide-induced amnesia in mice

Toshitaka Nabeshima; Kaname Itoh; Kazuaki Kawashima; Tsutomu Kameyama

doi:10.1016/0091-3057(89)90034-8

Effects of 5-HT₂ receptor antagonist on cycloheximide-induced amnesia in mice

Toshitaka Nabeshima, Kaname Itoh, Kazuaki Kawashima, Tsutomu Kameyama

Research output: Contribution to journal › Article › peer-review

32 Citations (Scopus)

Abstract

A role played by serotonergic neuronal system in cycloheximide (CXM)-induced amnesia was studied in mice using a step-down passive avoidance task. CXM (30 mg/kg SC) given immediately after training caused impairment of memory. Nonselective serotonin (5-HT) antagonist methysergide and selective 5-HT₂ antagonist ritanserin significantly attenuated impairment of memory caused by CXM. 5-HT₁ antagonist (±)-pindolol had no effect on CXM-induced amnesia. The antiamnesic effect of ritanserin on CXM-induced amnesia was antagonized by 5-HT (ICV), but not by nonselective 5-HT agonist 5-methoxy-N,N-dimethyltryptamine and 5-HT_1A selective agonist 8-hydroxy-2-(di-n-propylamino)tetralin at the dose level which did not cause the memory disruption. Scopolamine antagonized the antiamnesic effects of methysergide and ritanserin on CXM-induced amnesia. These results suggest that 5-HT₂ receptors and cholinergic neuronal system may play an important role in memory formation.

Original language	English
Pages (from-to)	787-790
Number of pages	4
Journal	Pharmacology, Biochemistry and Behavior
Volume	32
Issue number	3
DOIs	https://doi.org/10.1016/0091-3057(89)90034-8
Publication status	Published - 03-1989
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biochemistry
Toxicology
Pharmacology
Clinical Biochemistry
Biological Psychiatry
Behavioral Neuroscience

Access to Document

10.1016/0091-3057(89)90034-8

Cite this

@article{551c74779f7f4c0eb979f97acc09723e,

title = "Effects of 5-HT2 receptor antagonist on cycloheximide-induced amnesia in mice",

abstract = "A role played by serotonergic neuronal system in cycloheximide (CXM)-induced amnesia was studied in mice using a step-down passive avoidance task. CXM (30 mg/kg SC) given immediately after training caused impairment of memory. Nonselective serotonin (5-HT) antagonist methysergide and selective 5-HT2 antagonist ritanserin significantly attenuated impairment of memory caused by CXM. 5-HT1 antagonist (±)-pindolol had no effect on CXM-induced amnesia. The antiamnesic effect of ritanserin on CXM-induced amnesia was antagonized by 5-HT (ICV), but not by nonselective 5-HT agonist 5-methoxy-N,N-dimethyltryptamine and 5-HT1A selective agonist 8-hydroxy-2-(di-n-propylamino)tetralin at the dose level which did not cause the memory disruption. Scopolamine antagonized the antiamnesic effects of methysergide and ritanserin on CXM-induced amnesia. These results suggest that 5-HT2 receptors and cholinergic neuronal system may play an important role in memory formation.",

author = "Toshitaka Nabeshima and Kaname Itoh and Kazuaki Kawashima and Tsutomu Kameyama",

year = "1989",

month = mar,

doi = "10.1016/0091-3057(89)90034-8",

language = "English",

volume = "32",

pages = "787--790",

journal = "Pharmacology, Biochemistry and Behavior",

issn = "0091-3057",

publisher = "Elsevier Inc.",

number = "3",

}

TY - JOUR

T1 - Effects of 5-HT2 receptor antagonist on cycloheximide-induced amnesia in mice

AU - Nabeshima, Toshitaka

AU - Itoh, Kaname

AU - Kawashima, Kazuaki

AU - Kameyama, Tsutomu

PY - 1989/3

Y1 - 1989/3

N2 - A role played by serotonergic neuronal system in cycloheximide (CXM)-induced amnesia was studied in mice using a step-down passive avoidance task. CXM (30 mg/kg SC) given immediately after training caused impairment of memory. Nonselective serotonin (5-HT) antagonist methysergide and selective 5-HT2 antagonist ritanserin significantly attenuated impairment of memory caused by CXM. 5-HT1 antagonist (±)-pindolol had no effect on CXM-induced amnesia. The antiamnesic effect of ritanserin on CXM-induced amnesia was antagonized by 5-HT (ICV), but not by nonselective 5-HT agonist 5-methoxy-N,N-dimethyltryptamine and 5-HT1A selective agonist 8-hydroxy-2-(di-n-propylamino)tetralin at the dose level which did not cause the memory disruption. Scopolamine antagonized the antiamnesic effects of methysergide and ritanserin on CXM-induced amnesia. These results suggest that 5-HT2 receptors and cholinergic neuronal system may play an important role in memory formation.

AB - A role played by serotonergic neuronal system in cycloheximide (CXM)-induced amnesia was studied in mice using a step-down passive avoidance task. CXM (30 mg/kg SC) given immediately after training caused impairment of memory. Nonselective serotonin (5-HT) antagonist methysergide and selective 5-HT2 antagonist ritanserin significantly attenuated impairment of memory caused by CXM. 5-HT1 antagonist (±)-pindolol had no effect on CXM-induced amnesia. The antiamnesic effect of ritanserin on CXM-induced amnesia was antagonized by 5-HT (ICV), but not by nonselective 5-HT agonist 5-methoxy-N,N-dimethyltryptamine and 5-HT1A selective agonist 8-hydroxy-2-(di-n-propylamino)tetralin at the dose level which did not cause the memory disruption. Scopolamine antagonized the antiamnesic effects of methysergide and ritanserin on CXM-induced amnesia. These results suggest that 5-HT2 receptors and cholinergic neuronal system may play an important role in memory formation.

UR - http://www.scopus.com/inward/record.url?scp=0024475256&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024475256&partnerID=8YFLogxK

U2 - 10.1016/0091-3057(89)90034-8

DO - 10.1016/0091-3057(89)90034-8

M3 - Article

C2 - 2500672

AN - SCOPUS:0024475256

SN - 0091-3057

VL - 32

SP - 787

EP - 790

JO - Pharmacology, Biochemistry and Behavior

JF - Pharmacology, Biochemistry and Behavior

IS - 3

ER -

Effects of 5-HT₂ receptor antagonist on cycloheximide-induced amnesia in mice

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this