TY - JOUR
T1 - Effects of an antithrombin drug in patients with subacute exacerbations of Binswanger disease
AU - Tomimoto, Hidekazu
AU - Akiguchi, Ichiro
AU - Ohtani, Ryo
AU - Yagi, Hideo
AU - Ogura, Satoshi
AU - Wakita, Hideaki
PY - 2000/11
Y1 - 2000/11
N2 - The blood coagulation system has been shown to be activated in subacute exacerbations of Binswanger disease (BD). In our previous study, the antithrombin drug argatroban ameliorated the neurological exacerbations in a BD patient with antiphospholipid antibody syndrome. We have further examined the therapeutic efficacy of argatroban in 3 BD patients with subacute exacerbations, but without any immune-mediated prothrombotic complications. In 1 out of these 4 patients, treatment with sodium ozagrel, an antiplatelet drug was applied, but was ineffective. In all patients, argatroban treatment reduced the levels of the hemostatic markers, with a corresponding improvement in cognitive dysfunction and gait disorders. These results suggest that the antithrombin effect is true also for BD patients not compromised by the immune-mediated prothrombotic condition.
AB - The blood coagulation system has been shown to be activated in subacute exacerbations of Binswanger disease (BD). In our previous study, the antithrombin drug argatroban ameliorated the neurological exacerbations in a BD patient with antiphospholipid antibody syndrome. We have further examined the therapeutic efficacy of argatroban in 3 BD patients with subacute exacerbations, but without any immune-mediated prothrombotic complications. In 1 out of these 4 patients, treatment with sodium ozagrel, an antiplatelet drug was applied, but was ineffective. In all patients, argatroban treatment reduced the levels of the hemostatic markers, with a corresponding improvement in cognitive dysfunction and gait disorders. These results suggest that the antithrombin effect is true also for BD patients not compromised by the immune-mediated prothrombotic condition.
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U2 - 10.2169/internalmedicine.39.966
DO - 10.2169/internalmedicine.39.966
M3 - Article
C2 - 11065253
AN - SCOPUS:0034327968
SN - 0918-2918
VL - 39
SP - 966
EP - 969
JO - Internal Medicine
JF - Internal Medicine
IS - 11
ER -