Effects of arundic acid, an astrocytic modulator, on the cerebral and respiratory functions in severe hypoxia

Isato Fukushi, Kotaro Takeda, Shigefumi Yokota, Yohei Hasebe, Yutaka Sato, Mieczyslaw Pokorski, Jouji Horiuchi, Yasumasa Okada

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Mild hypoxia increases ventilation, but severe hypoxia depresses it. The mechanism of hypoxic ventilatory depression, in particular, the functional role of the cerebrum, is not fully understood. Recent progress in glial physiology has provided evidence that astrocytes play active roles in information processing in various brain functions. We investigated the hypothesis that astrocytic activation is necessary to maintain the cerebral function and ventilation in hypoxia, by examining the responses of EEG and ventilation to severe hypoxia before and after administration of a modulator of astrocytic function, arundic acid, in unanesthetized mice. Ventilatory parameters were measured by whole body plethysmography. When hypoxic ventilatory depression occurred, gamma frequency band of EEG was suppressed. Arundic acid further suppressed ventilation, and the EEG power was suppressed in a dose-dependent manner. Arundic acid also suppressed hypoxia-induced c-Fos expression in the hypothalamus. We conclude that severe hypoxia suppresses the cerebral function which could reduce the stimulus to the brainstem resulting in ventilatory depression. Astrocytic activation in hypoxia may counteract both cerebral and ventilatory suppression.

Original languageEnglish
Pages (from-to)24-29
Number of pages6
JournalRespiratory Physiology and Neurobiology
Volume226
DOIs
Publication statusPublished - 01-06-2016

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Ventilation
Respiratory Insufficiency
Electroencephalography
Whole Body Plethysmography
Brain Hypoxia
Cerebrum
Automatic Data Processing
Neuroglia
Astrocytes
Hypothalamus
Brain Stem
ONO2506
Hypoxia
Brain

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Physiology
  • Pulmonary and Respiratory Medicine

Cite this

Fukushi, Isato ; Takeda, Kotaro ; Yokota, Shigefumi ; Hasebe, Yohei ; Sato, Yutaka ; Pokorski, Mieczyslaw ; Horiuchi, Jouji ; Okada, Yasumasa. / Effects of arundic acid, an astrocytic modulator, on the cerebral and respiratory functions in severe hypoxia. In: Respiratory Physiology and Neurobiology. 2016 ; Vol. 226. pp. 24-29.
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Effects of arundic acid, an astrocytic modulator, on the cerebral and respiratory functions in severe hypoxia. / Fukushi, Isato; Takeda, Kotaro; Yokota, Shigefumi; Hasebe, Yohei; Sato, Yutaka; Pokorski, Mieczyslaw; Horiuchi, Jouji; Okada, Yasumasa.

In: Respiratory Physiology and Neurobiology, Vol. 226, 01.06.2016, p. 24-29.

Research output: Contribution to journalArticle

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