Effects of assisted reproductive technologies in neonates with indications for surgery (2007-2016)

S. Watanabe, Y. Kondo, A. Naoe, T. Yasui, T. Suzuki, F. Hara, N. Uga, M. Miyata, H. Boda

Research output: Contribution to journalArticle

Abstract

PURPOSE: Recently, the number of births using assisted reproductive technologies (ART) has increased. An associated increase in the incidence of congenital malformations in babies conceived using this technology has also been reported. Therefore, we aimed to investigate the rate of malformations in babies with neonatal surgical diseases, who were conceived using ART. MATERIALS AND METHODS: Between January 2007 and December 2016, 1737 patients were admitted to our hospital. We analyzed the incidence of congenital cardiac diseases, genetic anomalies, and congenital anomalies of the kidney and urinary tract (CAKUT) in neonates conceived by ART. The X 2 test and logistic regression analysis were used to assess the odds ratios (ORs) for congenital malformations. A P-value < 0.05 indicated statistical significance. RESULTS: The OR for CAKUT was 16.94 for the first-birth neonates conceived using ART, [P < 0.05, AUC (area under the curve) = 0.86]. However, for non-surgery neonates, the OR for CAKUT was 5.99 (P = 0.15, AUC= 0.87), compared to 32.27 (P < 0.05, AUC= 0.93) for parallel conditions in surgery-neonates. CONCLUSION: Neonates conceived using ART are prone to develop CAKUT, which will need surgical treatment. Therefore, more management is necessary for associated malformations in these babies, particularly in cases with CAKUT.

Original languageEnglish
Pages (from-to)379-385
Number of pages7
JournalJournal of Neonatal-Perinatal Medicine
Volume11
Issue number4
DOIs
Publication statusPublished - 01-01-2018

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All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health

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