Effects of Azelastine on Neutrophil Chemotaxis, Phagocytosis and Oxygen Radical Generation

Hirohiko Akamatsu, Yoshiki Miyachi, Yasuo Asada, Yukie Niwa

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)

Abstract

The effects of azelastine, an orally active anti-allergic drug, on several inflammatory parameters of human neutrophils, including human neutrophil chemotaxis, phagocytosis and generation of reactive oxygen species (ROS), was examined. ROS generated in a cell-free, xanthine-xanthine oxidase system was also assessed. The species investigated were superoxide radical anion (O2), hydrogen peroxide (H2O2) and hydroxyl radical (OH-). Azelastine significantly inhibited human neutrophil phagocytosis and the generation of O2-, H2O2, OH. by human neutrophils. However, the drug did not markedly affect human neutrophil chemotaxis or the ROS levels generated in the xanthine-xanthine oxidase system. The present study indicates that azelastine may exert an anti-inflammatory action by inhibiting human neutrophil phagocytosis as well as oxygen radical generation at the sites of inflammation.

Original languageEnglish
Pages (from-to)583-589
Number of pages7
JournalThe Japanese Journal of Pharmacology
Volume57
Issue number4
DOIs
Publication statusPublished - 01-1991
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pharmacology

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