TY - JOUR
T1 - Effects of behavioral activation on default mode network connectivity in subthreshold depression
T2 - A preliminary resting-state fMRI study
AU - Yokoyama, Satoshi
AU - Okamoto, Yasumasa
AU - Takagaki, Koki
AU - Okada, Go
AU - Takamura, Masahiro
AU - Mori, Asako
AU - Shiota, Syouichi
AU - Ichikawa, Naho
AU - Jinnin, Ran
AU - Yamawaki, Shigeto
N1 - Publisher Copyright:
© 2017 Elsevier B.V.
PY - 2018/2
Y1 - 2018/2
N2 - Background Subthreshold depression is a risk factor for major depressive disorder, and it is known to have a negative impact on quality of life (QOL). Although behavioral activation, which is one type of cognitive behavioral therapy, is an effective psychological intervention for subthreshold depression, neural mechanisms of behavioral activation are unclear. Enhanced functional connectivity between default mode network (DMN) and the other regions has been demonstrated in participants with subthreshold depression. The purpose of this study was to examine the effects of behavioral activation on DMN abnormalities by using resting-state functional MRI (rs-fMRI). Methods Participants with subthreshold depression (N =40) were randomly assigned to either an intervention group or a non-intervention group. They were scanned using rs-fMRI before and after the intervention. Independent component analysis indicated three subnetworks of the DMN. Results Analyzing intervention effects on functional connectivity of each subnetwork indicated that connectivity of the anterior DMN subnetwork with the dorsal anterior cingulate was reduced after the intervention. Moreover, this reduction was correlated with an increase in health-related QOL. Limitations We did not compare the findings with healthy participants. Further research should be conducted by including healthy controls to verify the results of this study. Conclusions Mechanisms of behavioral activation might be related to enhanced ability to independently use the dACC and the DMN, which increases an attention control to positive external stimuli. This is the first study to investigate neural mechanisms of behavioral activation using rs-fMRI.
AB - Background Subthreshold depression is a risk factor for major depressive disorder, and it is known to have a negative impact on quality of life (QOL). Although behavioral activation, which is one type of cognitive behavioral therapy, is an effective psychological intervention for subthreshold depression, neural mechanisms of behavioral activation are unclear. Enhanced functional connectivity between default mode network (DMN) and the other regions has been demonstrated in participants with subthreshold depression. The purpose of this study was to examine the effects of behavioral activation on DMN abnormalities by using resting-state functional MRI (rs-fMRI). Methods Participants with subthreshold depression (N =40) were randomly assigned to either an intervention group or a non-intervention group. They were scanned using rs-fMRI before and after the intervention. Independent component analysis indicated three subnetworks of the DMN. Results Analyzing intervention effects on functional connectivity of each subnetwork indicated that connectivity of the anterior DMN subnetwork with the dorsal anterior cingulate was reduced after the intervention. Moreover, this reduction was correlated with an increase in health-related QOL. Limitations We did not compare the findings with healthy participants. Further research should be conducted by including healthy controls to verify the results of this study. Conclusions Mechanisms of behavioral activation might be related to enhanced ability to independently use the dACC and the DMN, which increases an attention control to positive external stimuli. This is the first study to investigate neural mechanisms of behavioral activation using rs-fMRI.
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U2 - 10.1016/j.jad.2017.10.021
DO - 10.1016/j.jad.2017.10.021
M3 - Article
C2 - 29065364
AN - SCOPUS:85032878626
SN - 0165-0327
VL - 227
SP - 156
EP - 163
JO - Journal of Affective Disorders
JF - Journal of Affective Disorders
ER -