Effects of Central Muscle Relaxants on the Morphine-induced Straub Tail Reaction

Tsutomu Kameyama, Toshitaka Nabeshima, Makoto Ukai

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

An investigation of the pharmacological mechanism of the Straub tail reaction (STR) was made of the intracerebral (i.c.) injection of morphine. In addition, the effects of central muscle relaxants on the STR were examined. The STR was elicited by i.c. injection of morphine. Meprobamate, haloperidol, l,3-diphenyl-5-(2-dimethylaminopropion-amide)-pyrazole [difenamizole] and β-(p-chlorophenyl)-γ-aminobutyric acid [baclofen] apparently decreased the STR by systemic administration. In mice injected i.c. with difenamizole or baclofen, moreover, the STR was noticeably inhibited. Especially, baclofen decreased the STR in the approximate one-thousandth of the dose by systemic administration. Thus it appears that the central nervous system may have a profound significance for the manifestation of the STR due to morphine in mice.

Original languageEnglish
Pages (from-to)1837-1839
Number of pages3
JournalChemical and Pharmaceutical Bulletin
Volume25
Issue number7
DOIs
Publication statusPublished - 01-01-1977
Externally publishedYes

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Central Muscle Relaxants
Baclofen
Morphine
Tail
Meprobamate
Aminobutyrates
Neurology
Haloperidol
Amides
Injections
Central Nervous System
Pharmacology
difenamizole

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Drug Discovery

Cite this

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abstract = "An investigation of the pharmacological mechanism of the Straub tail reaction (STR) was made of the intracerebral (i.c.) injection of morphine. In addition, the effects of central muscle relaxants on the STR were examined. The STR was elicited by i.c. injection of morphine. Meprobamate, haloperidol, l,3-diphenyl-5-(2-dimethylaminopropion-amide)-pyrazole [difenamizole] and β-(p-chlorophenyl)-γ-aminobutyric acid [baclofen] apparently decreased the STR by systemic administration. In mice injected i.c. with difenamizole or baclofen, moreover, the STR was noticeably inhibited. Especially, baclofen decreased the STR in the approximate one-thousandth of the dose by systemic administration. Thus it appears that the central nervous system may have a profound significance for the manifestation of the STR due to morphine in mice.",
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Effects of Central Muscle Relaxants on the Morphine-induced Straub Tail Reaction. / Kameyama, Tsutomu; Nabeshima, Toshitaka; Ukai, Makoto.

In: Chemical and Pharmaceutical Bulletin, Vol. 25, No. 7, 01.01.1977, p. 1837-1839.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Effects of Central Muscle Relaxants on the Morphine-induced Straub Tail Reaction

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AU - Nabeshima, Toshitaka

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