Effects of cepharanthin on neutrophil chemotaxis, phagocytosis, and reactive oxygen species generation

H. Akamatsu, J. Komura, Y. Asada, Y. Niwa

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

The effects of cepharanthin on inflammatory parameters such as neutrophi1 chemotaxis, phagocytosis and reactive oxygen species (ROS) generation, were examined. Cepharanthin significantly decreased the levels of O2-, H2O2, and OH· generated by neutrophils. H2O2 and OH· generated in a cell-free, xanthine-xanthine oxidase system were also reduced in the presence of cepharanthin. However, the drug did not affect neutrophil chemotaxis or phagocytosis. The present study indicates that cepharanthin is an effective ROS scavenger, exerting its anti-inflammatory action by reducing the potent ROS species excessively generated in tissues and organs, especially at the sites of inflammation.

Original languageEnglish
Pages (from-to)643-648
Number of pages6
JournalJournal of Dermatology
Volume18
Issue number11
DOIs
Publication statusPublished - 1991
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Dermatology

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