TY - JOUR
T1 - Effects of cepharanthin on neutrophil chemotaxis, phagocytosis, and reactive oxygen species generation
AU - Akamatsu, H.
AU - Komura, J.
AU - Asada, Y.
AU - Niwa, Y.
PY - 1991
Y1 - 1991
N2 - The effects of cepharanthin on inflammatory parameters such as neutrophi1 chemotaxis, phagocytosis and reactive oxygen species (ROS) generation, were examined. Cepharanthin significantly decreased the levels of O2-, H2O2, and OH· generated by neutrophils. H2O2 and OH· generated in a cell-free, xanthine-xanthine oxidase system were also reduced in the presence of cepharanthin. However, the drug did not affect neutrophil chemotaxis or phagocytosis. The present study indicates that cepharanthin is an effective ROS scavenger, exerting its anti-inflammatory action by reducing the potent ROS species excessively generated in tissues and organs, especially at the sites of inflammation.
AB - The effects of cepharanthin on inflammatory parameters such as neutrophi1 chemotaxis, phagocytosis and reactive oxygen species (ROS) generation, were examined. Cepharanthin significantly decreased the levels of O2-, H2O2, and OH· generated by neutrophils. H2O2 and OH· generated in a cell-free, xanthine-xanthine oxidase system were also reduced in the presence of cepharanthin. However, the drug did not affect neutrophil chemotaxis or phagocytosis. The present study indicates that cepharanthin is an effective ROS scavenger, exerting its anti-inflammatory action by reducing the potent ROS species excessively generated in tissues and organs, especially at the sites of inflammation.
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U2 - 10.1111/j.1346-8138.1991.tb03149.x
DO - 10.1111/j.1346-8138.1991.tb03149.x
M3 - Article
C2 - 1800530
AN - SCOPUS:0026317211
SN - 0385-2407
VL - 18
SP - 643
EP - 648
JO - Journal of Dermatology
JF - Journal of Dermatology
IS - 11
ER -