Effects of clindamycin on human neutrophil functions in vitro

H. Akamatsu, M. Mishima, T. Horio

Research output: Contribution to journalArticlepeer-review

Abstract

Effects of clindamycin on [Ca2+] i in neutrophils, neutrophil chemotaxis, phagocytosis, and reactive oxygen species (ROS) generation were investigated in vitro. ROS generated in a cell-free, xanthine-xanthine oxidase system was also assessed. The species examined were superoxide radical anion (O2-), hydrogen peroxide (H2O2), and hydroxyl radical (OH·). Clindamycin significantly decreased the levels of O2-, H2O2, and OH· generated by neutrophils. On the other hand, the drug did not markedly affect [Ca2+] i in neutrophils, neutrophil chemotaxis, phagocytosis, and the ROS levels generated in a xanthine-xanthine oxidase system. The present study seems to indicate that clindamycin is not an ROS scavenger but exerts as anti-inflammatory action by inhibiting neutrophil-derived ROS generation at the sites of inflammation.

Original languageEnglish
Pages (from-to)35-39
Number of pages5
JournalActa Dermatologica - Kyoto
Volume93
Issue number1
Publication statusPublished - 1998

All Science Journal Classification (ASJC) codes

  • Dermatology

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