Effects of dietary vegetable oils on behavior and drug responses in mice

Tsutomu Kameyama, Tatsuo Ohhara, Yoshie Nakashima, Yukio Naito, Min Zhao Huang, Shiro Watanabe, Tetsuyuki Kobayashi, Harumi Okuyama, Kiyofumi Yamada, Toshitaka Nabeshima

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Previously, we noted significant differences in the behavioral patterns of mice fed safflower oil with a very low α-linolenate/linoleate ratio and perilla oil with a high α-linolenate/linoleate ratio from mothers to offsprings. In this report, we compared the behavior and drug responses in mice fed diets containing six different vegetable oils-corn, rapeseed, soybean, safflower, perilla and a mixture of perilla and safflower oils-for a relatively short period: 8 months after weaning. Soybean oil is a component of most conventional diets and was used as a control. The α- linolenate/linoleate ratios of the oils appeared to affect the locomotor activities in a wheel cage: the activity decreased in the order of safflower, the mixture (1:1) and the perilla oil groups. However, the rapeseed oil group exhibited much higher locomotor activity than that expected from the α- linolenate/linoleate ratio. Additionally, the rapeseed oil group exhibited unusual behavior patterns, including higher ambulation and rearing activities, faster acquisition of the water maze task and slower habituation behavior as compared with the control group. Susceptibility to pentobarbital anesthesia tended to be higher in the rapeseed oil group. The differences in the α-linolenate/linoleate ratios of these oils alone do not account for the observed differences in the behavioral patterns among the six dietary groups. Although we cannot exclude the possibility that the observed behavioral anomaly is due to the unique fatty acid composition of rapeseed oil, we speculate that a factor(s) other than fatty acids in rapeseed oil affected nervous system functions.

Original languageEnglish
Pages (from-to)400-404
Number of pages5
JournalBiological and Pharmaceutical Bulletin
Volume19
Issue number3
DOIs
Publication statusPublished - 01-01-1996
Externally publishedYes

Fingerprint

Unsaturated Dietary Fats
alpha-Linolenic Acid
Plant Oils
Linoleic Acid
Carthamus tinctorius
Safflower Oil
Pharmaceutical Preparations
Locomotion
Oils
Fatty Acids
Perilla
Diet
Brassica rapa
Soybean Oil
Pentobarbital
Weaning
Soybeans
Nervous System
Zea mays
Walking

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmaceutical Science

Cite this

Kameyama, Tsutomu ; Ohhara, Tatsuo ; Nakashima, Yoshie ; Naito, Yukio ; Huang, Min Zhao ; Watanabe, Shiro ; Kobayashi, Tetsuyuki ; Okuyama, Harumi ; Yamada, Kiyofumi ; Nabeshima, Toshitaka. / Effects of dietary vegetable oils on behavior and drug responses in mice. In: Biological and Pharmaceutical Bulletin. 1996 ; Vol. 19, No. 3. pp. 400-404.
@article{096bf03db93a4b44af7a5d3b0a243bee,
title = "Effects of dietary vegetable oils on behavior and drug responses in mice",
abstract = "Previously, we noted significant differences in the behavioral patterns of mice fed safflower oil with a very low α-linolenate/linoleate ratio and perilla oil with a high α-linolenate/linoleate ratio from mothers to offsprings. In this report, we compared the behavior and drug responses in mice fed diets containing six different vegetable oils-corn, rapeseed, soybean, safflower, perilla and a mixture of perilla and safflower oils-for a relatively short period: 8 months after weaning. Soybean oil is a component of most conventional diets and was used as a control. The α- linolenate/linoleate ratios of the oils appeared to affect the locomotor activities in a wheel cage: the activity decreased in the order of safflower, the mixture (1:1) and the perilla oil groups. However, the rapeseed oil group exhibited much higher locomotor activity than that expected from the α- linolenate/linoleate ratio. Additionally, the rapeseed oil group exhibited unusual behavior patterns, including higher ambulation and rearing activities, faster acquisition of the water maze task and slower habituation behavior as compared with the control group. Susceptibility to pentobarbital anesthesia tended to be higher in the rapeseed oil group. The differences in the α-linolenate/linoleate ratios of these oils alone do not account for the observed differences in the behavioral patterns among the six dietary groups. Although we cannot exclude the possibility that the observed behavioral anomaly is due to the unique fatty acid composition of rapeseed oil, we speculate that a factor(s) other than fatty acids in rapeseed oil affected nervous system functions.",
author = "Tsutomu Kameyama and Tatsuo Ohhara and Yoshie Nakashima and Yukio Naito and Huang, {Min Zhao} and Shiro Watanabe and Tetsuyuki Kobayashi and Harumi Okuyama and Kiyofumi Yamada and Toshitaka Nabeshima",
year = "1996",
month = "1",
day = "1",
doi = "10.1248/bpb.19.400",
language = "English",
volume = "19",
pages = "400--404",
journal = "Biological and Pharmaceutical Bulletin",
issn = "0918-6158",
publisher = "Pharmaceutical Society of Japan",
number = "3",

}

Kameyama, T, Ohhara, T, Nakashima, Y, Naito, Y, Huang, MZ, Watanabe, S, Kobayashi, T, Okuyama, H, Yamada, K & Nabeshima, T 1996, 'Effects of dietary vegetable oils on behavior and drug responses in mice', Biological and Pharmaceutical Bulletin, vol. 19, no. 3, pp. 400-404. https://doi.org/10.1248/bpb.19.400

Effects of dietary vegetable oils on behavior and drug responses in mice. / Kameyama, Tsutomu; Ohhara, Tatsuo; Nakashima, Yoshie; Naito, Yukio; Huang, Min Zhao; Watanabe, Shiro; Kobayashi, Tetsuyuki; Okuyama, Harumi; Yamada, Kiyofumi; Nabeshima, Toshitaka.

In: Biological and Pharmaceutical Bulletin, Vol. 19, No. 3, 01.01.1996, p. 400-404.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Effects of dietary vegetable oils on behavior and drug responses in mice

AU - Kameyama, Tsutomu

AU - Ohhara, Tatsuo

AU - Nakashima, Yoshie

AU - Naito, Yukio

AU - Huang, Min Zhao

AU - Watanabe, Shiro

AU - Kobayashi, Tetsuyuki

AU - Okuyama, Harumi

AU - Yamada, Kiyofumi

AU - Nabeshima, Toshitaka

PY - 1996/1/1

Y1 - 1996/1/1

N2 - Previously, we noted significant differences in the behavioral patterns of mice fed safflower oil with a very low α-linolenate/linoleate ratio and perilla oil with a high α-linolenate/linoleate ratio from mothers to offsprings. In this report, we compared the behavior and drug responses in mice fed diets containing six different vegetable oils-corn, rapeseed, soybean, safflower, perilla and a mixture of perilla and safflower oils-for a relatively short period: 8 months after weaning. Soybean oil is a component of most conventional diets and was used as a control. The α- linolenate/linoleate ratios of the oils appeared to affect the locomotor activities in a wheel cage: the activity decreased in the order of safflower, the mixture (1:1) and the perilla oil groups. However, the rapeseed oil group exhibited much higher locomotor activity than that expected from the α- linolenate/linoleate ratio. Additionally, the rapeseed oil group exhibited unusual behavior patterns, including higher ambulation and rearing activities, faster acquisition of the water maze task and slower habituation behavior as compared with the control group. Susceptibility to pentobarbital anesthesia tended to be higher in the rapeseed oil group. The differences in the α-linolenate/linoleate ratios of these oils alone do not account for the observed differences in the behavioral patterns among the six dietary groups. Although we cannot exclude the possibility that the observed behavioral anomaly is due to the unique fatty acid composition of rapeseed oil, we speculate that a factor(s) other than fatty acids in rapeseed oil affected nervous system functions.

AB - Previously, we noted significant differences in the behavioral patterns of mice fed safflower oil with a very low α-linolenate/linoleate ratio and perilla oil with a high α-linolenate/linoleate ratio from mothers to offsprings. In this report, we compared the behavior and drug responses in mice fed diets containing six different vegetable oils-corn, rapeseed, soybean, safflower, perilla and a mixture of perilla and safflower oils-for a relatively short period: 8 months after weaning. Soybean oil is a component of most conventional diets and was used as a control. The α- linolenate/linoleate ratios of the oils appeared to affect the locomotor activities in a wheel cage: the activity decreased in the order of safflower, the mixture (1:1) and the perilla oil groups. However, the rapeseed oil group exhibited much higher locomotor activity than that expected from the α- linolenate/linoleate ratio. Additionally, the rapeseed oil group exhibited unusual behavior patterns, including higher ambulation and rearing activities, faster acquisition of the water maze task and slower habituation behavior as compared with the control group. Susceptibility to pentobarbital anesthesia tended to be higher in the rapeseed oil group. The differences in the α-linolenate/linoleate ratios of these oils alone do not account for the observed differences in the behavioral patterns among the six dietary groups. Although we cannot exclude the possibility that the observed behavioral anomaly is due to the unique fatty acid composition of rapeseed oil, we speculate that a factor(s) other than fatty acids in rapeseed oil affected nervous system functions.

UR - http://www.scopus.com/inward/record.url?scp=13344284640&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=13344284640&partnerID=8YFLogxK

U2 - 10.1248/bpb.19.400

DO - 10.1248/bpb.19.400

M3 - Article

VL - 19

SP - 400

EP - 404

JO - Biological and Pharmaceutical Bulletin

JF - Biological and Pharmaceutical Bulletin

SN - 0918-6158

IS - 3

ER -

Kameyama T, Ohhara T, Nakashima Y, Naito Y, Huang MZ, Watanabe S et al. Effects of dietary vegetable oils on behavior and drug responses in mice. Biological and Pharmaceutical Bulletin. 1996 Jan 1;19(3):400-404. https://doi.org/10.1248/bpb.19.400