Effects of DM-9384, a pyrrolidone derivative, on alcohol- and chlordiazepoxide-induced amnesia in mice

Toshitaka Nabeshima, Keiko Tohyama, Tsutomu Kameyama

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

The effects of N- (2,6-dimethyl-phenyl)-2-(2-oxo-1-pyrrolidinyl) acetamide (DM-9384), a new pyrrolidone derivative, were investigated on ethanol- and chlordiazepoxide (CDP)-induced amnesia animal model using the passive avoidance task in comparison with aniracetam, another pyrrolidone derivative. Pretraining administration of DM-9384 attenuated ethanol- and CDP-induced amnesia, whereas aniracetam failed to do so. The effects of DM-9384 on CDP-induced amnesia were antagonized by bicuculline, a GABAA receptor antagonist, but not by scopolamine, a muscarinic acethylcholine receptor antagonist and flumazenil, a benzodiazepine receptor antagonist. These results suggest that DM-9384 attenuates CDP-induced amnesia by interacting with the GABAergic neuronal system.

Original languageEnglish
Pages (from-to)233-236
Number of pages4
JournalPharmacology, Biochemistry and Behavior
Volume36
Issue number2
DOIs
Publication statusPublished - 01-01-1990
Externally publishedYes

Fingerprint

Pyrrolidinones
Chlordiazepoxide
aniracetam
Amnesia
Alcohols
Derivatives
Ethanol
GABA-A Receptor Antagonists
Flumazenil
Scopolamine Hydrobromide
Bicuculline
Muscarinic Receptors
GABA-A Receptors
Animals
Animal Models
nefiracetam

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience

Cite this

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abstract = "The effects of N- (2,6-dimethyl-phenyl)-2-(2-oxo-1-pyrrolidinyl) acetamide (DM-9384), a new pyrrolidone derivative, were investigated on ethanol- and chlordiazepoxide (CDP)-induced amnesia animal model using the passive avoidance task in comparison with aniracetam, another pyrrolidone derivative. Pretraining administration of DM-9384 attenuated ethanol- and CDP-induced amnesia, whereas aniracetam failed to do so. The effects of DM-9384 on CDP-induced amnesia were antagonized by bicuculline, a GABAA receptor antagonist, but not by scopolamine, a muscarinic acethylcholine receptor antagonist and flumazenil, a benzodiazepine receptor antagonist. These results suggest that DM-9384 attenuates CDP-induced amnesia by interacting with the GABAergic neuronal system.",
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Effects of DM-9384, a pyrrolidone derivative, on alcohol- and chlordiazepoxide-induced amnesia in mice. / Nabeshima, Toshitaka; Tohyama, Keiko; Kameyama, Tsutomu.

In: Pharmacology, Biochemistry and Behavior, Vol. 36, No. 2, 01.01.1990, p. 233-236.

Research output: Contribution to journalArticle

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