Effects of DM-9384 and aniracetam on learning in normal and basal forebrain-lesioned rats

Toshitaka Nabeshima, S. I. Ogawa, T. Kameyama, T. Shiotani, Y. Takasu, T. Sakurai, M. Hasegawa, T. Hasegawa

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Effects of DM-9384 [(N-2, 6-dimetyl-phenyl)-2-(2-oxo-1-pyrrolidinyl) acetamide] on learning and memory and/or the choline acetyltransferase (CAT) activity in normal and basal forebrain (BF)-lesioned rats were investigated using the multiple T-maze and passive avoidance tasks. Aniracetam was used as the reference drug. In the multiple T-maze task, DM-9384 not only ameliorated the learning deficit of the BF-lesioned rats, but also showed a tendency to enhance the learning ability of their normal counterparts. Aniracetam only achieved the former. In the passive avoidance task, both DM-9384 (3 mg/kg) and aniracetam (10 mg/kg) attenuated the BF-lesion-induced amnesia. DM-9384 (3 mg/kg) showed a tendency to increase CAT activity in the fronto-parietal cortex. These results suggest that DM-9384 enhances the acquisition of spatial information, and that its effect may be produced through an activation of the cholinergic neuronal system.

Original languageEnglish
Pages (from-to)1-14
Number of pages14
JournalResearch Communications in Psychology, Psychiatry and Behavior
Volume16
Issue number1-2
Publication statusPublished - 01-12-1991
Externally publishedYes

Fingerprint

aniracetam
Learning
Choline O-Acetyltransferase
Parietal Lobe
Aptitude
Amnesia
Cholinergic Agents
nefiracetam
Basal Forebrain

All Science Journal Classification (ASJC) codes

  • Psychiatry and Mental health

Cite this

Nabeshima, T., Ogawa, S. I., Kameyama, T., Shiotani, T., Takasu, Y., Sakurai, T., ... Hasegawa, T. (1991). Effects of DM-9384 and aniracetam on learning in normal and basal forebrain-lesioned rats. Research Communications in Psychology, Psychiatry and Behavior, 16(1-2), 1-14.
Nabeshima, Toshitaka ; Ogawa, S. I. ; Kameyama, T. ; Shiotani, T. ; Takasu, Y. ; Sakurai, T. ; Hasegawa, M. ; Hasegawa, T. / Effects of DM-9384 and aniracetam on learning in normal and basal forebrain-lesioned rats. In: Research Communications in Psychology, Psychiatry and Behavior. 1991 ; Vol. 16, No. 1-2. pp. 1-14.
@article{6ebc2edb105b4481ab43ed4642bb209f,
title = "Effects of DM-9384 and aniracetam on learning in normal and basal forebrain-lesioned rats",
abstract = "Effects of DM-9384 [(N-2, 6-dimetyl-phenyl)-2-(2-oxo-1-pyrrolidinyl) acetamide] on learning and memory and/or the choline acetyltransferase (CAT) activity in normal and basal forebrain (BF)-lesioned rats were investigated using the multiple T-maze and passive avoidance tasks. Aniracetam was used as the reference drug. In the multiple T-maze task, DM-9384 not only ameliorated the learning deficit of the BF-lesioned rats, but also showed a tendency to enhance the learning ability of their normal counterparts. Aniracetam only achieved the former. In the passive avoidance task, both DM-9384 (3 mg/kg) and aniracetam (10 mg/kg) attenuated the BF-lesion-induced amnesia. DM-9384 (3 mg/kg) showed a tendency to increase CAT activity in the fronto-parietal cortex. These results suggest that DM-9384 enhances the acquisition of spatial information, and that its effect may be produced through an activation of the cholinergic neuronal system.",
author = "Toshitaka Nabeshima and Ogawa, {S. I.} and T. Kameyama and T. Shiotani and Y. Takasu and T. Sakurai and M. Hasegawa and T. Hasegawa",
year = "1991",
month = "12",
day = "1",
language = "English",
volume = "16",
pages = "1--14",
journal = "Research Communications in Psychology, Psychiatry and Behavior",
issn = "0362-2428",
publisher = "PJD Publications Ltd",
number = "1-2",

}

Nabeshima, T, Ogawa, SI, Kameyama, T, Shiotani, T, Takasu, Y, Sakurai, T, Hasegawa, M & Hasegawa, T 1991, 'Effects of DM-9384 and aniracetam on learning in normal and basal forebrain-lesioned rats', Research Communications in Psychology, Psychiatry and Behavior, vol. 16, no. 1-2, pp. 1-14.

Effects of DM-9384 and aniracetam on learning in normal and basal forebrain-lesioned rats. / Nabeshima, Toshitaka; Ogawa, S. I.; Kameyama, T.; Shiotani, T.; Takasu, Y.; Sakurai, T.; Hasegawa, M.; Hasegawa, T.

In: Research Communications in Psychology, Psychiatry and Behavior, Vol. 16, No. 1-2, 01.12.1991, p. 1-14.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Effects of DM-9384 and aniracetam on learning in normal and basal forebrain-lesioned rats

AU - Nabeshima, Toshitaka

AU - Ogawa, S. I.

AU - Kameyama, T.

AU - Shiotani, T.

AU - Takasu, Y.

AU - Sakurai, T.

AU - Hasegawa, M.

AU - Hasegawa, T.

PY - 1991/12/1

Y1 - 1991/12/1

N2 - Effects of DM-9384 [(N-2, 6-dimetyl-phenyl)-2-(2-oxo-1-pyrrolidinyl) acetamide] on learning and memory and/or the choline acetyltransferase (CAT) activity in normal and basal forebrain (BF)-lesioned rats were investigated using the multiple T-maze and passive avoidance tasks. Aniracetam was used as the reference drug. In the multiple T-maze task, DM-9384 not only ameliorated the learning deficit of the BF-lesioned rats, but also showed a tendency to enhance the learning ability of their normal counterparts. Aniracetam only achieved the former. In the passive avoidance task, both DM-9384 (3 mg/kg) and aniracetam (10 mg/kg) attenuated the BF-lesion-induced amnesia. DM-9384 (3 mg/kg) showed a tendency to increase CAT activity in the fronto-parietal cortex. These results suggest that DM-9384 enhances the acquisition of spatial information, and that its effect may be produced through an activation of the cholinergic neuronal system.

AB - Effects of DM-9384 [(N-2, 6-dimetyl-phenyl)-2-(2-oxo-1-pyrrolidinyl) acetamide] on learning and memory and/or the choline acetyltransferase (CAT) activity in normal and basal forebrain (BF)-lesioned rats were investigated using the multiple T-maze and passive avoidance tasks. Aniracetam was used as the reference drug. In the multiple T-maze task, DM-9384 not only ameliorated the learning deficit of the BF-lesioned rats, but also showed a tendency to enhance the learning ability of their normal counterparts. Aniracetam only achieved the former. In the passive avoidance task, both DM-9384 (3 mg/kg) and aniracetam (10 mg/kg) attenuated the BF-lesion-induced amnesia. DM-9384 (3 mg/kg) showed a tendency to increase CAT activity in the fronto-parietal cortex. These results suggest that DM-9384 enhances the acquisition of spatial information, and that its effect may be produced through an activation of the cholinergic neuronal system.

UR - http://www.scopus.com/inward/record.url?scp=0026352310&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026352310&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:0026352310

VL - 16

SP - 1

EP - 14

JO - Research Communications in Psychology, Psychiatry and Behavior

JF - Research Communications in Psychology, Psychiatry and Behavior

SN - 0362-2428

IS - 1-2

ER -