TY - JOUR
T1 - Effects of DM-9384 and aniracetam on learning in normal and basal forebrain-lesioned rats
AU - Nabeshima, T.
AU - Ogawa, S. I.
AU - Kameyama, T.
AU - Shiotani, T.
AU - Takasu, Y.
AU - Sakurai, T.
AU - Hasegawa, M.
AU - Hasegawa, T.
PY - 1991
Y1 - 1991
N2 - Effects of DM-9384 [(N-2, 6-dimetyl-phenyl)-2-(2-oxo-1-pyrrolidinyl) acetamide] on learning and memory and/or the choline acetyltransferase (CAT) activity in normal and basal forebrain (BF)-lesioned rats were investigated using the multiple T-maze and passive avoidance tasks. Aniracetam was used as the reference drug. In the multiple T-maze task, DM-9384 not only ameliorated the learning deficit of the BF-lesioned rats, but also showed a tendency to enhance the learning ability of their normal counterparts. Aniracetam only achieved the former. In the passive avoidance task, both DM-9384 (3 mg/kg) and aniracetam (10 mg/kg) attenuated the BF-lesion-induced amnesia. DM-9384 (3 mg/kg) showed a tendency to increase CAT activity in the fronto-parietal cortex. These results suggest that DM-9384 enhances the acquisition of spatial information, and that its effect may be produced through an activation of the cholinergic neuronal system.
AB - Effects of DM-9384 [(N-2, 6-dimetyl-phenyl)-2-(2-oxo-1-pyrrolidinyl) acetamide] on learning and memory and/or the choline acetyltransferase (CAT) activity in normal and basal forebrain (BF)-lesioned rats were investigated using the multiple T-maze and passive avoidance tasks. Aniracetam was used as the reference drug. In the multiple T-maze task, DM-9384 not only ameliorated the learning deficit of the BF-lesioned rats, but also showed a tendency to enhance the learning ability of their normal counterparts. Aniracetam only achieved the former. In the passive avoidance task, both DM-9384 (3 mg/kg) and aniracetam (10 mg/kg) attenuated the BF-lesion-induced amnesia. DM-9384 (3 mg/kg) showed a tendency to increase CAT activity in the fronto-parietal cortex. These results suggest that DM-9384 enhances the acquisition of spatial information, and that its effect may be produced through an activation of the cholinergic neuronal system.
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M3 - Article
AN - SCOPUS:0026352310
SN - 0362-2428
VL - 16
SP - 1
EP - 14
JO - Research Communications in Psychology, Psychiatry and Behavior
JF - Research Communications in Psychology, Psychiatry and Behavior
IS - 1-2
ER -