TY - JOUR
T1 - Effects of donepezil (Aricept) on the rapid eye movement sleep of normal subjects
AU - Kanbayashi, T.
AU - Sugiyama, T.
AU - Aizawa, R.
AU - Saito, Y.
AU - Ogawa, Y.
AU - Kitajima, T.
AU - Kaneko, Y.
AU - Abe, M.
AU - Shimizu, T.
PY - 2002
Y1 - 2002
N2 - Donepezil (Aricept) is a therapeutic drug for the treatment of Alzheimer's disease (AD). However, there have been only two reports describing the effects of donepezil on sleep as assessed by nocturnal polysomnography (PSG). With this in mind, the effects of donepezil on the sleep of healthy subjects was evaluated using PSG. The results indicated that the percentage of rapid eye movement sleep to total sleep time was increased significantly by a single dose of 5 mg of donepezil when given to healthy subjects immediately before retiring to bed.
AB - Donepezil (Aricept) is a therapeutic drug for the treatment of Alzheimer's disease (AD). However, there have been only two reports describing the effects of donepezil on sleep as assessed by nocturnal polysomnography (PSG). With this in mind, the effects of donepezil on the sleep of healthy subjects was evaluated using PSG. The results indicated that the percentage of rapid eye movement sleep to total sleep time was increased significantly by a single dose of 5 mg of donepezil when given to healthy subjects immediately before retiring to bed.
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U2 - 10.1046/j.1440-1819.2002.01008.x
DO - 10.1046/j.1440-1819.2002.01008.x
M3 - Article
C2 - 12047608
AN - SCOPUS:0036317679
VL - 56
SP - 307
EP - 308
JO - Psychiatry and Clinical Neurosciences
JF - Psychiatry and Clinical Neurosciences
SN - 1323-1316
IS - 3
ER -